The integration of MRI and transcranial focused ultrasound represents a disruptive technology that has many potential applications. This seminar will provide an overview of a new research program I established in […]
Our lab seeks to gain granular descriptions of synaptic, neuronal and network dynamics in the brain. To this end, we use a combination of in vitro and in vivo electrophysiology, two-photon imaging/uncaging, optogenetics and behavioral approaches, and use computational simulations to coalesce these levels of analysis in tractable interpretations. I will present results from ongoing […]
Combining open-ended interviews (outside the scanner) with structural, trial-by-trial, and resting-state functional MRI neuroimaging, we examined real-time functional neural dynamics underlying diverse urban mid-adolescents’ cognitive and emotional engagement with compelling […]
Successful pursuit of reinforcers requires the generation of predictions and evaluation of outcomes. Midbrain dopamine neurons and their projections to the striatum are thought to be critical for these processes. […]
The human brain has the remarkable capacity to transport the self into the past and future. While previously thought of as distinct functions, recent research has shown that memory for […]
Understanding how the brain encodes, stores, and uses information is a central goal of neuroscience. Many neuropsychiatric and neurodegenerative disorders, including autism spectrum disorder, post-traumatic stress disorder (PTSD), and Alzheimer’s […]
Dr. Mayo will talk about studies involving animal-to-human translational work highlighting how endocannabinoid function regulates stress reactivity and fear learning, leveraging human behavioral pharmacology and neuroimaging. She will also highlight outcomes from a recent clinical trial exploring how augmenting cannabinoid function impacts clinical, behavioral, and neural measures in people with PTSD.
Natural visual processing entails a complex interplay between sensory input, behavioral context, and on-going brain dynamics. Our lab seeks to understand how these processes give rise to goal-directed visual behaviors, by exploring the neural circuits mediating ethologically relevant behaviors that laboratory mice perform, including prey capture and distance estimation. We are also implementing novel experimental […]
This talk will highlight recent efforts to generate and analyze spatially resolved molecular datasets to better understand structure–function relationships in the human brain, particularly in the context of complex brain disorders. While single-cell and single-nucleus sequencing approaches have rapidly advanced our ability to define molecularly distinct cell populations, these methods often lack the spatial and […]
Despite decades of research on the properties of ventral tegmental area (VTA) dopamine neurons, the precise information encoded by these cells in reward learning and motivated behavior remains uncertain. In […]
The Neuroscience Research Colloquium (NRC), is a series of lectures featuring local and international neuroscientists.
