Dr. Michael J. Strong: The discovery of NF242 as a potential biotherapeutic for ALS: when a little competition is a good thing
Rudy North Lecture Theatre, Djavad Mowafaghian Centre for Brain Health 2215 Wesbrook Mall, VancouverTDP-43 protein aggregation is a pathological hallmark of amyotrophic lateral sclerosis (ALS). In this talk, Dr. Michael Strong will discuss the discovery of NF242, an N-terminal fragment of the RNA-binding protein RGNEF that competes for interactions with TDP-43 and reduces its toxicity in experimental models of ALS. Dr. Strong will describe the development of NF242 […]
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