The effects of maternal immune activation on early development in an outbred strain of mice

Rudy North Lecture Theatre, Djavad Mowafaghian Centre for Brain Health 2215 Wesbrook Mall, Vancouver

Our lab is interested in the neural bases for social function, and we use mouse models for diseases that have social deficits at their core. This talk will present our recent work looking at postnatal development, juvenile behaviours and autophagy in a mouse model of perinatal infection. Rudy North Lecture Theatre "Live" Screening Zoom option […]


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Spontaneous activity, memory replay, and the default mode network

Rudy North Lecture Theatre, Djavad Mowafaghian Centre for Brain Health 2215 Wesbrook Mall, Vancouver

Spontaneous activity accounts for most of what the brain does and is likely to be key for information processing in the brain, but its function is still quite mysterious. Two key spontaneous activity processes are the Default Mode Network (DMN), a set of areas that are most markedly connected and active during behavioural idleness, and […]


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Dr. Cheryl Wellington: Fluid biomarkers in neurology: Clinical and translational studies

Rudy North Lecture Theatre, Djavad Mowafaghian Centre for Brain Health 2215 Wesbrook Mall, Vancouver

Diseases of the brain are among the most challenging disorders to diagnose and treat. Unlike cancer, where human tissue biopsy specimens are routinely collected, brain disorders lack routine access to specimens that are essential to make progress in understanding pathophysiology and developing effective treatments. Currently, most brain diseases are studied in living patients using neuroimaging […]


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Dr. Jorn Diedrichsen: Exploring the role of the human cerebellum across functional domains

The cerebellum has evolved to support basic sensory-motor functions. In the human brain, the cerebellar circuitry has dramatically expanded and contributes to virtually every cognitive function, including working memory, language, and social cognition. Given its uniform cytoarchitecture, it has long been hypothesized that the cerebellar circuit performs a common computation across all these functional domains. […]


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Dr. Rutsuko Ito: Ventral hippocampal circuits and the arbitration of approach-avoidance conflict

Rudy North Lecture Theatre, Djavad Mowafaghian Centre for Brain Health 2215 Wesbrook Mall, Vancouver

Approach-avoidance (AA) conflict resolution is a form of decision making that is fundamentally important for survival and requires the effective evaluation of affective stimuli or events with mixed outcomes (positive and negative). Despite the prevailing view of hippocampal involvement in learning and memory processes, the hippocampus is also thought to be involved in the resolution […]


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Dr. Kate Wassum: Amygdala circuitry in reward learning and decision making

Rudy North Lecture Theatre, Djavad Mowafaghian Centre for Brain Health 2215 Wesbrook Mall, Vancouver

To make adaptive decisions we must cast ourselves into the future and consider the outcomes of our potential choices. This prospective consideration is informed by our memories. I will discuss our lab’s recent work investigating the neural circuits responsible for encoding, updating, and retrieving reward memories for use in the considerations underlying decision making. We […]


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Dr. Edward F. Chang: Towards a Speech Neuroprosthetic

Rudy North Lecture Theatre, Djavad Mowafaghian Centre for Brain Health 2215 Wesbrook Mall, Vancouver

Speaking is a unique and defining human behavior.  Over the past decade, we have focused on deciphering the basic neural code that underlies our ability to speak fluently. During speech production, vocal tract movement gestures for all speech sounds are encoded by highly specialized neural activity, organized as a map, in the human speech motor […]


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Dr. Bojana Stefanovic: Neurovascular unit dysfunction in a model of TBI

Rudy North Lecture Theatre, Djavad Mowafaghian Centre for Brain Health 2215 Wesbrook Mall, Vancouver

Mild traumatic brain injury (mTBI) is the most common type of traumatic brain injury globally. Although its consequences may be short term, mTBI often leads to long-term neuropsychiatric and neurological impairments and has been estimated to increase the probability of later life dementia up to six-fold. It is presently not clear what neuropathological changes underlie […]


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Dr. Shigeki Watanabe: Ultrafast recycling of synaptic vesicles

Rudy North Lecture Theatre, Djavad Mowafaghian Centre for Brain Health 2215 Wesbrook Mall, Vancouver

In 1973 John Heuser and Tom Reese demonstrated that neurotransmitter was released from neurons via the fusion of neurotransmitter-filled vesicles with the cell membrane.  But at the same time, these experiments launched a controversy that is unresolved today – do vesicles collapse into the membrane and are then recycled slowly on the order of 20 […]


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Dr. Pascal Kaeser: Mechanisms and Roles for Fast Dopamine Signaling

Rudy North Lecture Theatre, Djavad Mowafaghian Centre for Brain Health 2215 Wesbrook Mall, Vancouver

Dopamine is a neuromodulator that codes information on various time scales. I will discuss recent progress on the identification of fast release mechanisms for dopamine in the mouse striatum. I will present data on triggering mechanisms of dopamine release and evaluate its roles in striatal regulation. In the long-term, our work will allow for a better understanding of the mechanisms and […]


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