Events

This talk will introduce emerging roles for microglia and discrete innate immune signaling pathways in the pathogenesis of Alzheimer’s disease, tauopathies, and brain injury.  

A large body of recent work has focused on the problem of inferring neural population dynamics from recordings of neural activity. However, these models typically ignore the fact that the […]

Dr. Bolton will discuss how early-life adversity impacts brain development in the context of psychiatric disorders, with a focus on the role of microglia in the synaptic rewiring of stress-sensitive […]

Bioelectronic implants for brain stimulation provide critical tools for treating brain diseases as well as investigating fundamental biology but require invasive surgery. In this talk I will discuss a new […]

I will present work we have pursued to identify key mechanisms explaining aberrant pain processing by the nervous system as well as co-morbidities that develop from sustained pain hypersensitivity. This […]

The human brain comprises billions of neurons that communicate primarily through chemical synapses by releasing diverse neuromodulators, which regulate perception, movement, learning, and memory. Dissecting the neural mechanisms in both […]

TDP-43 protein aggregation is a pathological hallmark of amyotrophic lateral sclerosis (ALS). In this talk, Dr. Michael Strong will discuss the discovery of NF242, an N-terminal fragment of the RNA-binding […]

The head-direction (HD) circuit, an upstream provider of orientation signals for navigation, maintains coherent internal orientation memory that stays stable within each environment for weeks. During non-REM sleep, when hippocampal trajectories are replayed for memory formation, HD cells remain coordinated and directly influence this hippocampal replay. This suggests the HD system conveys a "virtual" orientation […]

The brain is constantly receiving sensory information from inside of the body, but it is underappreciated how this internal sensory information can affect animal behavior. To address this, we are developing the small transparent fish Danionella cerebrum as a model for brain-body signaling. I will describe our work characterizing the anatomy, molecular subtypes, and sexual […]

How are synaptic networks formed during development and remodeled during learning and disease? This is the main question that drives Dr. Eroglu’s research. In particular, she investigates the roles of glial cells in the development, remodeling and function of synaptic circuits. In Dr. Eroglu’s talk, she will share findings from her lab on two distinct molecular mechanisms through […]