Events

The human brain comprises billions of neurons that communicate primarily through chemical synapses by releasing diverse neuromodulators, which regulate perception, movement, learning, and memory. Dissecting the neural mechanisms in both physiology and disease requires precise in vivo monitoring of neuromodulator dynamics. In the past few years, we and others have developed a series of GPCR-activation‒based […]

TDP-43 protein aggregation is a pathological hallmark of amyotrophic lateral sclerosis (ALS). In this talk, Dr. Michael Strong will discuss the discovery of NF242, an N-terminal fragment of the RNA-binding protein RGNEF that competes for interactions with TDP-43 and reduces its toxicity in experimental models of ALS. Dr. Strong will describe the development of NF242 […]

The head-direction (HD) circuit, an upstream provider of orientation signals for navigation, maintains coherent internal orientation memory that stays stable within each environment for weeks. During non-REM sleep, when hippocampal trajectories are replayed for memory formation, HD cells remain coordinated and directly influence this hippocampal replay. This suggests the HD system conveys a "virtual" orientation […]