Events

A key behavioral characteristic of autistic individuals is difficulty with mentalization—the ability to understand and respond to the mental states of others. While these difficulties have important social and clinical consequences, the neurocognitive mechanisms underlying them remain poorly understood. In this presentation, I will argue that one reason for this lack of progress is the limitation of standard experimental approaches […]

I will be presenting data on an animal model of Multiple Sclerosis (MS) progression, how we have used this model to better understand disease progression and to understand how MS treatments impact this process. By going back and forth between the animal model and MS tissues, we have learned about what can trigger so-called “compartmentalized […]

Title: Capabilities and Collaborations: Charting the NINC’s second decade Presented by: Jeff LeDue The NeuroImaging and NeuroComputation (NINC) core has grown rapidly over its first decade adding many new instruments which extend our community’s capabilities for measuring key aspects of brain structure and function.  This presentation will highlight these new instruments, including our 3-photon microscope, […]

This talk will introduce emerging roles for microglia and discrete innate immune signaling pathways in the pathogenesis of Alzheimer’s disease, tauopathies, and brain injury.  

A large body of recent work has focused on the problem of inferring neural population dynamics from recordings of neural activity. However, these models typically ignore the fact that the brain contains multiple cell types, which limits their ability to predict the effects of cell-specific perturbations, or to capture the functional roles of distinct cell […]

Dr. Bolton will discuss how early-life adversity impacts brain development in the context of psychiatric disorders, with a focus on the role of microglia in the synaptic rewiring of stress-sensitive neurons after early-life adversity. I will also describe our work on sex-dependent differences in microglia and synaptic development, as well as the molecular mechanisms by […]

Bioelectronic implants for brain stimulation provide critical tools for treating brain diseases as well as investigating fundamental biology but require invasive surgery. In this talk I will discuss a new class of implants which we named Circulatronics: wherein intravenously introduced bioelectronic devices travel through the body’s global internal roadways i.e., the circulatory system, and autonomously […]

I will present work we have pursued to identify key mechanisms explaining aberrant pain processing by the nervous system as well as co-morbidities that develop from sustained pain hypersensitivity. This includes the discovery of impaired inhibition resulting from chloride dysregulation in neuropathic pain conditions, leading to crosstalk between sensory channels, a probable substrate of abnormal […]