Events

Dr. Bolton will discuss how early-life adversity impacts brain development in the context of psychiatric disorders, with a focus on the role of microglia in the synaptic rewiring of stress-sensitive neurons after early-life adversity. I will also describe our work on sex-dependent differences in microglia and synaptic development, as well as the molecular mechanisms by […]

Bioelectronic implants for brain stimulation provide critical tools for treating brain diseases as well as investigating fundamental biology but require invasive surgery. In this talk I will discuss a new class of implants which we named Circulatronics: wherein intravenously introduced bioelectronic devices travel through the body’s global internal roadways i.e., the circulatory system, and autonomously […]

I will present work we have pursued to identify key mechanisms explaining aberrant pain processing by the nervous system as well as co-morbidities that develop from sustained pain hypersensitivity. This […]

The human brain comprises billions of neurons that communicate primarily through chemical synapses by releasing diverse neuromodulators, which regulate perception, movement, learning, and memory. Dissecting the neural mechanisms in both […]

The head-direction (HD) circuit, an upstream provider of orientation signals for navigation, maintains coherent internal orientation memory that stays stable within each environment for weeks. During non-REM sleep, when hippocampal […]