Events

Bioelectronic implants for brain stimulation provide critical tools for treating brain diseases as well as investigating fundamental biology but require invasive surgery. In this talk I will discuss a new class of implants which we named Circulatronics: wherein intravenously introduced bioelectronic devices travel through the body’s global internal roadways i.e., the circulatory system, and autonomously […]

I will present work we have pursued to identify key mechanisms explaining aberrant pain processing by the nervous system as well as co-morbidities that develop from sustained pain hypersensitivity. This includes the discovery of impaired inhibition resulting from chloride dysregulation in neuropathic pain conditions, leading to crosstalk between sensory channels, a probable substrate of abnormal […]

The human brain comprises billions of neurons that communicate primarily through chemical synapses by releasing diverse neuromodulators, which regulate perception, movement, learning, and memory. Dissecting the neural mechanisms in both physiology and disease requires precise in vivo monitoring of neuromodulator dynamics. In the past few years, we and others have developed a series of GPCR-activation‒based […]

The head-direction (HD) circuit, an upstream provider of orientation signals for navigation, maintains coherent internal orientation memory that stays stable within each environment for weeks. During non-REM sleep, when hippocampal trajectories are replayed for memory formation, HD cells remain coordinated and directly influence this hippocampal replay. This suggests the HD system conveys a "virtual" orientation […]