Events

Title: Capabilities and Collaborations: Charting the NINC’s second decade Presented by: Jeff LeDue The NeuroImaging and NeuroComputation (NINC) core has grown rapidly over its first decade adding many new instruments which extend our community’s capabilities for measuring key aspects of brain structure and function.  This presentation will highlight these new instruments, including our 3-photon microscope, […]

This talk will introduce emerging roles for microglia and discrete innate immune signaling pathways in the pathogenesis of Alzheimer’s disease, tauopathies, and brain injury.  

A large body of recent work has focused on the problem of inferring neural population dynamics from recordings of neural activity. However, these models typically ignore the fact that the brain contains multiple cell types, which limits their ability to predict the effects of cell-specific perturbations, or to capture the functional roles of distinct cell […]

Dr. Bolton will discuss how early-life adversity impacts brain development in the context of psychiatric disorders, with a focus on the role of microglia in the synaptic rewiring of stress-sensitive neurons after early-life adversity. I will also describe our work on sex-dependent differences in microglia and synaptic development, as well as the molecular mechanisms by […]

Bioelectronic implants for brain stimulation provide critical tools for treating brain diseases as well as investigating fundamental biology but require invasive surgery. In this talk I will discuss a new class of implants which we named Circulatronics: wherein intravenously introduced bioelectronic devices travel through the body’s global internal roadways i.e., the circulatory system, and autonomously […]

I will present work we have pursued to identify key mechanisms explaining aberrant pain processing by the nervous system as well as co-morbidities that develop from sustained pain hypersensitivity. This includes the discovery of impaired inhibition resulting from chloride dysregulation in neuropathic pain conditions, leading to crosstalk between sensory channels, a probable substrate of abnormal […]

The human brain comprises billions of neurons that communicate primarily through chemical synapses by releasing diverse neuromodulators, which regulate perception, movement, learning, and memory. Dissecting the neural mechanisms in both physiology and disease requires precise in vivo monitoring of neuromodulator dynamics. In the past few years, we and others have developed a series of GPCR-activation‒based […]

The head-direction (HD) circuit, an upstream provider of orientation signals for navigation, maintains coherent internal orientation memory that stays stable within each environment for weeks. During non-REM sleep, when hippocampal trajectories are replayed for memory formation, HD cells remain coordinated and directly influence this hippocampal replay. This suggests the HD system conveys a "virtual" orientation […]