2021/22 Neuroscience Research Colloquium Schedule

Fall 2021

SEPTEMBER 17 – IN PERSON AT RUDY NORTH LECTURE THEATRE

  • Host: Jeff LeDue, UBC
  • Speakers: GPN CONP Scholars
  • Title: Canadian Open Neuroscience Platform Scholars Update
  • Zoom option if unable to attend in person:
    Zoom link:  https://ubc.zoom.us/  (click on “Join a meeting”)
    Meeting ID:  95496 072083
    Passcode:  072083

OCTOBER 1 – RUDY NORTH LECTURE THEATRE – “LIVE” SCREENING

  • Host: Dr. Annie Ciernia
  • Speaker: Dr. Ashley Kopec, Albany Medical College
  • Title: Sex-specific impact of immune signaling on adolescent neural and social development
  • Join in person in the auditorium or via the zoom option. The presenter will be remote.
  • Zoom link here (click on “Join a meeting”)
  • Meeting ID:  95496 072083
  • Passcode: 072083

In this presentation, Dr. Ashley Kopec will discuss published work examining the role of microglia, the resident immune cells in the brain, in neural and social development during adolescence in male and female rats. Then, she will discuss unpublished work aimed at understanding how opioid exposures during adolescence interact with microglia-mediated development to alter future reward-related behaviors.

There will be a virtual trainee meeting with Dr. Kopec immediately following her talk (~noon). If you would like to attend the trainee meeting please email annie.ciernia@ubc.ca to sign up. There are limited spots available on a first come first serve basis.

OCTOBER 8 – IN PERSON AT RUDY NORTH LECTURE THEATRE

  • Host: Dr. Tim Murphy and Dr. Matthew Sacheli
  • Speakers: Dynamic Brain Circuits Cluster and the BC Brain Wellness Program
  • Title: Brain-Tech 2021 Hackathon: student teams innovation showcase
  • Zoom option if unable to attend in person:
  • Zoom link here (click on “Join a meeting”)
  • Meeting ID:  95496 072083
  • Passcode:  072083

This colloquium will present innovation from the top student teams of the Brain-Tech 2021: Idea Generation and Hackathon for Brain Wellness. The Hackathon was hosted by the Dynamic Brain Circuits in Health and Disease Cluster, the BC Brain Wellness Program, and the Djavad  Mowafaghian Centre for Brain Health. The Brain-Tech 2021 winners will discuss and demo their work which aims to improve brain wellness.

OCTOBER 15 – IN PERSON AT RUDY NORTH LECTURE THEATRE

  • Host: Dr. Catharine Winstanley
  • Speaker: Sasha Wiley-Shaw, Sexual Violence Prevention and Response Office, UBC
  • Title: Preventing and Responding to Sexualized Violence
  • Zoom option if unable to attend in person:
  • Zoom link here (click on “Join a meeting”)
  • Meeting ID: 95496 072083
  • Passcode: 072083

SVPRO will present UBC’s approach to preventing and responding to sexualized violence, with a focus on key principles for supporting survivors. The presentation will include what constitutes sexualized violence and prohibited relationships, standards and considerations for safe and respectful working and learning environments, and how to respond to a disclosure, with approaches to help mitigate impacts and reduce harm. This presentation is part one of a two-part series; part 2 (November 19) will focus on reporting options.

 OCTOBER 22 – RUDY NORTH LECTURE THEATRE “LIVE” SCREENING

  • Host: Dr. Catharine Rankin
  • Speaker: Dr. Donald Wilson, New York University
  • Title: The olfactory mosaic: How diverse networks shape perception.
  • Zoom option if unable to attend in person:
  • Zoom link here (Click on “Join a meeting”)
  • Meeting ID: 95496 072083
  • Passcode: 072083

Our perception of the world begins with stimuli in the environment but is then dramatically shaped by our expectations, past experience, and internal state.  Olfactory perception is especially sensitive to these kinds of modulation.  In fact, input from a diverse network of brain regions conveying multisensory, homeostatic and experience-dependent information converges on the olfactory system as early as the first stages of odor processing.  This talk will describe our work over the past few years on how activity in non-olfactory regions shapes odor coding and perception.  What you smell is not necessarily what you get.

OCTOBER 29 – IN PERSON AT RUDY NORTH LECTURE THEATRE

  • Host: Dr. Annie Ciernia
  • Speaker: Dr. David Gosselin, University of Laval
  • Title: Genome-wide approaches to understanding microglia identity and function
  • Zoom option if unable to attend in person:
  • Zoom link here (Click on “Join a meeting”)
  • Meeting ID: 95496-072083
  • Passcode: 072083

Microglia are the macrophages of the brain and participate to its development, homeostasis, and defense against pathogens and injuries. Notably, genetic evidence suggests that they are critically involved in neurodegenerative diseases, including Alzheimer’s disease. However, our knowledge of the molecular processes that regulate these cells in the brain remains very rudimentary.

Over the past few years, we have concentrated our efforts on trying to understand how gene regulation is achieved in microglia. In particular, we provided evidence using mouse microglia that signaling factors in the brain provide important regulatory input that enable microglia to acquire their cellular identity. Importantly, our recent work on human microglia shows that axes of signaling pathways – transcription factors that shape the microglial epigenome and transcriptional characteristics are relatively well conserved between the mouse and human. My talk will provide an overview of these recent findings, and elaborate on the current approaches that we use to gain a better understanding of the epigenomic mechanisms underlying the different cellular functions of microglia in the brain.

NOVEMBER 5 – RUDY NORTH LECTURE THEATRE “LIVE” SCREENING

  • Host: Dr. Jason Snyder
  • Speaker: Dr. Christine Denny, Columbia University
  • Title: Development of a whole-brain memory trace pipeline for activity-dependent tagging murine lines
  • Zoom option if unable to attend in person:
  • Zoom link  here (Click on “Join a meeting”)
  • Meeting ID: 95496 072083
  • Passcode: 072083

We previously created a mouse model to permanently label neurons activated during learning, the ArcCreERT2 mice (Denny et al., 2014, Neuron). In our first publication, we extensively characterized the ArcCreERT2 mice and manipulated various parameters to correlate behavioral expression with memory tagging. Using contextual fear conditioning (CFC), we showed that mice re-exposed to a fearful context freeze more and have a greater percentage of reactivated cells in the dentate gyrus (DG) and in CA3 than mice exposed to a novel context. Overall, we found that context, time, adult hippocampal neurogenesis, and stress impact cognition and mood, and these alterations are paralleled by changes in memory trace activation in the hippocampus. In our more recent studies, we have investigated how disease states and pharmacological manipulations impact memory traces (Perusini et al., 2017; Mastrodonato et al., 2018; Lacagnina et al., 2019; Leal Santos et al., 2021).

Our ongoing/planned projects are to identify: 1) how individual memories are stored throughout the entire brain using a novel whole-brain imaging pipeline we have recently developed, 2) how multiple memories are co-stored throughout the brain using a new activity-dependent viral strategy, and 3) how disease states impact memories, often resulting in memory loss.

NOVEMBER 19 -IN PERSON AT RUDY NORTH LECTURE THEATRE

  • Host: Dr. Catharine Winstanley
  • Speaker: Sasha Wiley-Shaw, Sexual Violence Prevention and Response Office, UBC
  • Title: Reporting Options for Sexualized Violence
  • Zoom option if unable to attend in person:
  • Zoom link here (Click on “Join a meeting”)
  • Meeting ID: 95496 072083
  • Passcode: 072083

SVPRO is back for a second session! This session will focus on the different options that are available for reporting when sexualized violence has occurred. Not everyone wants to report after being impacted by sexualized violence, and that’s completely okay. When folks do want to report, it’s important that they know the full range of options and considerations. Join us to learn about UBC systems, police reporting, and human rights reporting systems, when each may apply, and how SVPRO supports people navigating these processes.

NOVEMBER 26 – THE TALK FOR TODAY HAS BEEN CANCELLED – IT WILL BE RESCHEDULED FOR DECEMBER 17

  • Host: Dr. Tim Murphy
  • Speaker: Dr. Majid Mohajerani, University of Lethbridge/UBC
  • Title:  Spontaneous activity, memory replay, and the default mode network.

DECEMBER 3 – RUDY NORTH LECTURE THEATRE “LIVE” SCREENING

  • Host: Dr. Annie Ciernia
  • Speaker: Dr. Tamara Franklin, Dalhousie University
  • Title: The effects of maternal immune activation on early development in an outbred strain of mice.
  • Zoom option if unable to attend in person:
  • Zoom link here (Click on “Join a meeting”)
  • Meeting ID: 95496 072083
  • Passcode: 072083

Dr. Franklin’s lab is interested in the neural bases for social function, and they use mouse models for diseases that have social deficits at their core. This talk will present their recent work looking at postnatal development, juvenile behaviours and autophagy in a mouse model of perinatal infection.

There will be a virtual lunch with trainees following the talk (~noon). If you are interested in attending the trainee virtual lunch, please RSVP to Dr. Annie Ciernia (annie.ciernia@ubc.ca) by Monday, Nov 29th at 5pm. Spots are limited and first come first serve.

DECEMBER 10 – IN PERSON AT RUDY NORTH LECTURE THEATRE

  • Host: Dr. Shernaz Bamji
  • Speaker: Dr. Jessica Rosin, UBC
  • Title: Unraveling microglial heterogeneity and stress responses in the embryonic hypothalamus
  • Zoom option if unable to attend in person:
  • Zoom link here (Click on “Join a meeting”)
  • Meeting ID: 95496 072083
  • Passcode: 072083

The hypothalamus is a powerful brain region that is responsive to external stressors and is critical for maintaining homeostatic processes, including energy balance, thermoregulation, circadian rhythm, mood, and reproduction. Microglia, the resident macrophages and phagocytic immune cells of the brain, survey their environment, respond to insults, and dispose of cellular debris. Microglia can also sense external inputs (e.g., infection, stress, etc.), causing them to interact with neighboring cells to control their local environment. The interplay between hypothalamic neurons and microglia as they integrate stressors to regulate homeostasis is of growing interest. We asked if embryonic hypothalamic microglia were stress responsive and, if so, whether their precocious activation perturbs nearby neural stem cell programs. Our findings suggest that immature hypothalamic microglia play an unappreciated role in translating maternal stressors to sexually dimorphic perturbation of neurodevelopmental programs. 

DECEMBER 17 – IN PERSON AT RUDY NORTH LECTURE THEATRE

  • Host: Dr. Tim Murphy
  • Speaker: Dr. Majid Mohajerani, University of Lethbridge/UBC
  • Title: Spontaneous activity, memory replay, and the default mode network.
  • Zoom option if unable to attend in person:
  • Zoom link here (Click on “Join a meeting”)
  • Meeting ID: 95496 072083
  • Passcode: 072083

Spontaneous activity accounts for most of what the brain does and is likely to be key for information processing in the brain, but its function is still quite mysterious. Two key spontaneous activity processes are the Default Mode Network (DMN), a set of areas that are most markedly connected and active during behavioural idleness, and memory replay, the spontaneous reactivation of neural patterns occurring during experience. In the Mohajerani lab, we test the hypothesis that the DMN plays a key role in memory replay processes. This theory, if confirmed, would bring important conceptual advances: to memory studies, as it would provide a mechanism supporting the formation and consolidation of complex memory representations. I will explore this theory by our ongoing studies of neural activity over the whole mouse cortex in animals running memory tasks.

TERM 2 (WINTER 2022)

JANUARY 14 – IN PERSON AT RUDY NORTH LECTURE THEATRE

  • Host: Dr. Catharine Winstanley
  • Speaker: Dr. Brian MacVicar, UBC
  • Title: TBD
  • Zoom option if unable to attend in person
  • Zoom link here (click on “Join a meeting”)
  • Meeting ID: 99412 188589
  • Passcode: 188589

JANUARY 21 – IN PERSON AT RUDY NORTH LECTURE THEATRE

  • Host: Dr. Catharine Winstanley
  • Speaker: Dr. John Kramer, UBC
  • Title: TBD
  • Zoom option if unable to attend in person
  • Zoom link here (click on “Join a meeting”)
  • Meeting ID: 99412 188589
  • Passcode: 188589

JANUARY 28 – IN PERSON AT RUDY NORTH LECTURE THEATRE

  • Host: Dr. Lynn Raymond
  • Speaker: Dr. Eric Yttri, Carnegie Mellon University
  • Title: TBD
  • Zoom option if unable to attend in person
  • Zoom link here (click on “Join a meeting”)
  • Meeting ID: 99412 188589
  • Passcode: 188589

FEBRUARY 4 – IN PERSON AT RUDY NORTH LECTURE THEATRE

  • Host: Dr. Catharine Winstanley
  • Speaker: Dr. Mihaela Iordanova, Concordia University
  • Title: Spreading fear across the memory network: behavioural and neural mechanisms
  • Zoom option if unable to attend in person
  • Zoom link here (click on “Join a meeting”)
  • Meeting ID: 99412 188589
  • Passcode: 188589

FEBRUARY 11 – IN PERSON AT RUDY NORTH LECTURE THEATRE

  • Host: Dr. Catharine Winstanley
  • Speaker: Dr. Cheryl Wellington, UBC
  • Title: TBD
  • Zoom option if unable to attend in person
  • Zoom link here (click on “Join a meeting”)
  • Meeting ID: 99412 188589
  • Passcode: 188589

FEBRUARY 18 – IN PERSON AT RUDY NORTH LECTURE THEATRE

  • Host: Ronan Denyer/Dr. Lara Boyd
  • Speaker: Dr. Jorn Diedrichsen, Western University
  • Title: TBD
  • Zoom option if unable to attend in person
  • Zoom link here (click on “Join a meeting”)
  • Meeting ID: 99412 188589
  • Passcode: 188589

FEBRUARY 25 – IN PERSON AT RUDY NORTH LECTURE THEATRE

  • Host: Dr. Annie Ciernia
  • Speaker: Dr. Anthony Filiano, Duke University
  • Title: TBD
  • Zoom option if unable to attend in person
  • Zoom link here (click on “Join a meeting”)
  • Meeting ID: 99412 188589
  • Passcode: 188589

MARCH 4 – IN PERSON AT RUDY NORTH LECTURE THEATRE

  • Host: Dr. Catharine Winstanley
  • Speaker: Dr. Eric S. Kim – UBC Department of Psychology
  • Title: TBD
  • Zoom option if unable to attend in person
  • Zoom link here (click on “Join a meeting”)
  • Meeting ID: 99412 188589
  • Passcode: 188589

MARCH 11 – IN PERSON AT RUDY NORTH LECTURE THEATRE

  • Host: Dr. Jason Snyder
  • Speaker: Dr. Rutsuko Ito, University of Toronto
  • Title: Ventral hippocampal circuits and the arbitration of approach-avoidance conflict\
  • Zoom option if unable to attend in person
  • Zoom link here (click on “Join a meeting”)
  • Meeting ID: 99412 188589
  • Passcode: 188589

MARCH 18 – IN PERSON AT RUDY NORTH LECTURE THEATRE

  • Host: Dr. Stan Floresco
  • Speaker: Dr. Kate Wassum, UCLA
  • Title: Corticoamygdala circuitry in reward learning and pursuit
  • Zoom option if unable to attend in person
  • Zoom link here (click on “Join a meeting”)
  • Meeting ID: 99412 188589
  • Passcode: 188589

MARCH 25

  • Host: Dr. Janet Werker and the UBC Language Sciences Initiative
  • Speaker: Dr. Edward F. Chang, University of California, San Francisco
  • Title: TBD
  • Zoom option if unable to attend in person
  • Zoom link here (click on “Join a meeting”)
  • Meeting ID: 99412 188589
  • Passcode: 188589

APRIL 1 – IN PERSON AT RUDY NORTH LECTURE THEATRE

  • Host: Dr. Timothy Murphy
  • Speaker: Dr. Bojana Stefanovic, University of Toronto
  • Title: TBD
  • Zoom option if unable to attend in person
  • Zoom link here (click on “Join a meeting”)
  • Meeting ID: 99412 188589
  • Passcode: 188589

APRIL 8 – IN PERSON AT RUDY NORTH LECTURE THEATRE

  • Host: Dr. Kota Mizumoto
  • Speaker: Dr. Shigeki Watanabe, Johns Hopkins University
  • Title: TBD
  • Zoom option if unable to attend in person
  • Zoom link here (click on “Join a meeting”)
  • Meeting ID: 99412 188589
  • Passcode: 188589

APRIL 22

  • Host: Hong Lu
  • Speaker: Dr. Pascal Kaeser, Harvard University
  • Title: TBD
  • Zoom option if unable to attend in person
  • Zoom link here (click on “Join a meeting”)
  • Meeting ID: 99412 188589
  • Passcode: 188589

APRIL 29

  • Host: Dr. Jason Snyder
  • Speaker: Dr. Nelson Spruston, Janelia Research Campus, Virginia
  • Title: TBD
  • Zoom option if unable to attend in person
  • Zoom link here (click on “Join a meeting”)
  • Meeting ID: 99412 188589
  • Passcode: 188589

MAY 6

  • Host: Dr. Annie Ciernia
  • Speaker: Dr. Elizabeth Heller, University of Pennsylvania
  • Title: TBD
  • Zoom option if unable to attend in person
  • Zoom link here (click on “Join a meeting”)
  • Meeting ID: 99412 188589
  • Passcode: 188589

MAY 13

  • Host: Dr. Lynn Raymond
  • Speaker: Dr. Joseph Cheer, University of Maryland
  • Title: TBD
  • Zoom option if unable to attend in person
  • Zoom link here (click on “Join a meeting”)
  • Meeting ID: 99412 188589
  • Passcode: 188589

MAY 20

  • Host: Dr. Jason Snyder
  • Speaker: Dr. Michael Drew, University of Texas at Austin
  • Title: TBD
  • Zoom option if unable to attend in person
  • Zoom link here (click on “Join a meeting”)
  • Meeting ID: 99412 188589
  • Passcode: 188589

MAY 27

  • Host: Dr. Lynn Raymond
  • Speaker: Dr. Rosemary Bagot, McGill University
  • Title: TBD
  • Zoom option if unable to attend in person
  • Zoom link here (click on “Join a meeting”)
  • Meeting ID: 99412 188589
  • Passcode: 188589

JUNE 10

  • Host: Dr. Kota Mizumoto
  • Speaker: Dr. Hokto Kazama, Riken Centre for Brain Science
  • Title: TBD
  • Zoom option if unable to attend in person
  • Zoom link here (click on “Join a meeting”)
  • Meeting ID: 99412 188589
  • Passcode: 188589