Ryan Hoiland

Degrees / Credentials

PhD (University of British Columbia)
MSc (University of British Columbia)
BHK (University of British Columbia)


Assistant Professor, Department of Medicine, Faculty of Medicine, UBC


Full Member

Dr. Hoiland completed his PhD (2015-2018) at the University of British Columbia Okanagan, where he studied cerebrovascular physiology and human adaptation to hypoxia. As a postdoctoral fellow, Dr. Hoiland investigated the pathophysiology of hypoxic-ischemic brain injury as well as traumatic spinal cord injury, with a focus on mitigating secondary hypoxic injury. Collectively, his training involved studying how the central nervous system responds to hypoxia in pre-clinical disease models, healthy humans, and patients. Dr. Hoiland now conducts research along the translational continuum with the aim of determining neuroprotective strategies to improve outcomes for patients suffering an acute central nervous system injury. Special interests include
developing strategies to optimize oxygen delivery to the brain or spinal cord following an acute injury and characterizing the role of neuroinflammation as a determinant of acute central nervous system injury severity.

Contact Info

Mailing Address
VGH Research Pavilion, Room 340
828 W 10th Ave
Vancouver, BC V5Z 1M9

Research Information

My research interests center on improving outcomes for patients that have suffered an acute central nervous system (CNS) injury, such as a hypoxic ischemic brain injury, traumatic brain injury, or traumatic spinal cord injury. These acute CNS injuries have dismal outcomes and currently lack efficacious therapies. The specific foci of my research are: 1) determining the mechanisms that impair the restoration of oxygen delivery and utilization within the CNS following an acute injury; 2) characterizing the role of neuroinflammation as a determinant of acute CNS injury severity; 3) Illuminating new therapeutic targets for the treatment of acute CNS injuries. Across these foci I employ several experimental paradigms including disease models (e.g., rodents), healthy human studies, and clinical studies. Separate to this work, I hold experience and interest in the mechanisms that regulate cerebrovascular function in humans, cerebrovascular health across the lifespan, and interventions/strategies to sustain or improve cerebrovascular function.



  • acute brain injury
  • cerebrovascular
  • neuromonitoring
  • neuroinflammation

Research Areas