Mahmoud Pouladi

Degrees / Credentials

BSc Hons (McMaster), MSc (McMaster), PhD (UBC)


Associate Professor, Department of Medical Genetics, Faculty of Medicine, UBC


Full Member

Mahmoud Pouladi was recruited to the Department of Medical Genetics at University of British Columbia (UBC) in July 2020. Prior to this, he was a Senior Principal Investigator and a Deputy Director of the Translational Labs in Genetic Medicine at the Agency for Science, Technology and Research (A*STAR) in Singapore. He was also an Associate Professor in the Department of Medicine at the National University of Singapore. Dr. Pouladi has been the recipient of a number of awards and distinctions including the Child & Family Research Institute Award for Outstanding Achievement by a Doctoral Candidate, the Canadian Institutes of Health Research Brain Star Award, and the British Columbia Innovation Council’s Ripples of Hope Award in Biotechnology & Entrepreneurship. In 2017, Dr. Pouladi was selected for the Interstellar Initiative, a joint program between the Japan Agency for Medical Research and Development and the New York Academy of Sciences, that recognizes “the world’s most promising Early Career Investigators in the fields of cancer, regenerative medicine, and neuroscience”. In 2020, Dr. Pouladi was awarded a 5-year Michael Smith Foundation for Health Research Scholar Award on “The use of human stem cells to understand mechanisms and develop treatments for neurological disorders”.

Contact Info

Lab Phone
604-875-2000 x4808
Mailing Address
Room 3104 938 W 28th Ave
Vancouver, BC V5Z 4H4

Research Information

The overriding goal of my research is to understand how discrete genetic factors contribute to the development of neurological disorders. We employ isogenic human pluripotent stem cells and transgenic animals to model disease, with the goal of delineating novel approaches to influence outcomes for neurological disorders. The current disease interests in the lab include developmental and degenerative disorders of learning and memory (Fragile X, Rett, Huntington disease) and white matter disorders (multiple sclerosis, and hypomyelinating leukodystrophies).



  • Neurodegenerative and neurodevelopmental disorders
  • Huntington disease
  • Fragile X syndrome
  • multiple sclerosis
  • preclinical translational research
  • animal models
  • human pluripotent stem cells
  • genome engineering