Hakima Moukhles

Dr. Moukhles’ lab focuses on the role of the dystroglycan multiprotein complex and its interaction with the extracellular matrix in the targeting and polarization of the water-permeable channel, aquaporin 4 to specialized membrane domains in astrocytes. Using a multidisciplinary approach applied to both in vitro and in vivo models, we are studying the mechanisms underlying aquaporin 4 localization in physiological and pathophysiological conditions including stroke.