Dr. Stephen Ferguson: G Protein-coupled Receptors, Vesicular Glutamate Transporters and β-arrestins as Targets to Attenuate Huntington’s and Alzheimer’s Disease Progression.

Huntington’s disease (HD) and Alzheimer’s disease (AD) are both neurodegenerative disorders that, despite differing in their underlying causes and specific symptoms, share several key features. These include age-related onset, progressive neuronal dysfunction and loss, cognitive decline, and a range of behavioral and psychiatric symptoms. Dr. Ferguson’s research presentation will explore the role and sex-specificity of metabotropic glutamate receptor 5 (mGluR5) in the progression and pathology of both HD and AD. In addition, the presentation will examine the therapeutic potential of alternative targets, such as vesicular glutamate transporter 3 (VGLUT3), M1 muscarinic acetylcholine receptors (M1 mAChR), and β-arrestins, for slowing disease progression and mitigating pathology in these disorders.

• Zoom option if unable to attend in person:
• Zoom link here (click on “Join a meeting”)
• Meeting ID: 91512 289258
• Passcode: 289258