Approach-avoidance (AA) conflict resolution is a form of decision making that is fundamentally important for survival and requires the effective evaluation of affective stimuli or events with mixed outcomes (positive and negative). Despite the prevailing view of hippocampal involvement in learning and memory processes, the hippocampus is also thought to be involved in the resolution of AA conflict by exaggerating the value of negative outcomes and increasing the tendency to avoid. Furthermore, work from my laboratory has implicated the ventral, but not the dorsal hippocampus, in mediating affective processes involving learned AA conflict. In this talk, I will be presenting a set of studies providing evidence of ventral hippocampal (vHPC) mediation of AA decision making when animals are exposed to affectively bivalent (conflicting) cues. I will also present chemogenetic evidence that the control over conflict-elicited AA behaviours is subfield, and pathway-specific, with the investigation extending to the wider extrinsic connectivity of the vHPC with the lateral septum and ventral striatum.
Rudy North Lecture Theatre “Live” Screening
Zoom option if unable to attend in person: