In this talk, I will describe two recent projects in my lab. In the first, we discovered that brain-wide spatiotemporal dynamics (i.e. traveling waves) are coordinated on a moment-to-moment basis between neocortex and striatum, thalamus, and midbrain. We used widefield calcium imaging and Neuropixels 2.0 recordings in combination to reveal the structure of these waves in the mouse brain, including a link to the underlying axonal architecture that supports them. Second, I will talk about our work developing a new version of the Neuropixels probe, called ‘Neuropixels Ultra’, which has much smaller and denser recording sites than previous versions. This configuration yields improved characteristics for some applications and reveals new observations about the biophysical phenomena observable with extracellular electrophysiology.