The talk will undertake an overview of the physiology of the human dying process as an in vivo model of brain ischemia physiology. The talk will cover the feasibility of undertaking this work at VGH and the characterization of the physiology of circulatory arrest in humans. Additionally, I will describe preliminary insights into the changes of the proteome and metabolome of the human brain during brain ischemia and use of whole brain autopsies for insights into disease mechanisms.