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Chromatin regulatory proteins are a major class of gene products for which sequence variants are associated with autism spectrum disorders and intellectual disability; however, the functional consequences of these mutations for brain development remain poorly understood. We are identifying molecular mechanisms through which chromatin regulatory enzymes promote the expression of synaptic gene products and functional neuronal maturation. I will discuss how our studies are working to build a foundation for understanding how dysregulation of chromatin regulation in the developing brain leads to neurodevelopmental disorders.