Loading Events
  • This event has passed.
  • Zoom option if unable to attend in person:
  • Zoom link here (click on “Join a meeting”)
  • Meeting ID: 91512 289258
  • Passcode: 289258

Chemical neurotransmission is essential for a variety of neural processes and is traditionally understood to be mediated by Ca2+-dependent exocytosis of synaptic vesicles. Nevertheless, it has been recognized for decades that taste receptor cells in taste buds do not possess synaptic vesicles, yet they can transmit gustatory information to the nervous system. Here I will describe the identification of a unique synapse of taste receptor cells where the ion-conducting pore of a voltage-gated channel, CALHM1/3, serves as the conduit for action potential-dependent neurotransmitter (ATP) release. This mechanism has been termed a ‘channel synapse.’ Anatomically, a channel synapse is characterized by its tripartite structure, which includes a presynaptic mitochondrion adjacent to a CALHM1/3-enriched plasma membrane that faces a post-synaptic afferent nerve. Our recent discoveries extend the roles of channel synapses to various extraoral physiological and pathophysiological processes.


April 19
11:00 am - 12:00 pm


Rudy North Lecture Theatre, Djavad Mowafaghian Centre for Brain Health
2215 Wesbrook Mall
Vancouver, British Columbia V6T 1Z3 Canada

+ Google Map

Back to Calendar