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X-WR-CALNAME:Djavad Mowafaghian Centre for Brain Health | DMCBH
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X-WR-CALDESC:Events for Djavad Mowafaghian Centre for Brain Health | DMCBH
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SUMMARY:Dr. Yulong Li: Quantitative imaging of neuromodulator dynamics in vivo by constructing new GRAB sensors
DESCRIPTION:The human brain comprises billions of neurons that communicate primarily through chemical synapses by releasing diverse neuromodulators\, which regulate perception\, movement\, learning\, and memory. Dissecting the neural mechanisms in both physiology and disease requires precise in vivo monitoring of neuromodulator dynamics. In the past few years\, we and others have developed a series of GPCR-activation‒based (GRAB) sensors that enable high-resolution monitoring of extracellular neuromodulator dynamics in behaving animals. Here\, I will present our latest GRAB sensors featuring large fluorescence lifetime changes\, which allow precise quantification of both phasic and tonic neuromodulator release. With these GRAB sensors\, we have monitored the dynamics of neuromodulators in mice in a wide range of physiological processes (reward\, motion\, etc.) and pathological conditions (Parkinson’s disease\, etc.).
URL:https://www.centreforbrainhealth.ca/events/dr-yulong-li/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
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DTSTART;TZID=America/Vancouver:20261023T110000
DTEND;TZID=America/Vancouver:20261023T120000
DTSTAMP:20261005T183252Z
CREATED:20260326T204056Z
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UID:17669-1792753200-1792756800@www.centreforbrainhealth.ca
SUMMARY:Dr. Michael J. Strong: The discovery of NF242 as a potential biotherapeutic for ALS: when a little competition is a good thing
DESCRIPTION:TDP-43 protein aggregation is a pathological hallmark of amyotrophic lateral sclerosis (ALS). In this talk\, Dr. Michael Strong will discuss the discovery of NF242\, an N-terminal fragment of the RNA-binding protein RGNEF that competes for interactions with TDP-43 and reduces its toxicity in experimental models of ALS. Dr. Strong will describe the development of NF242 as a potential biotherapeutic and what this work reveals about targeting pathological protein interactions in ALS. \n  \nDr. Michael J. Strong is a Distinguished University Professor in the Department of Clinical Neurological Sciences at Western University. He served as the President of the Canadian Institutes of Health Research from 2018 to 2023\, as the Dean of the Schulich School of Medicine & Dentistry at Western University from 2010 to 2018\, and from 2000 to 2010\, as Chief of Neurology and Co-Chair of the Department of Clinical Neurological Sciences. His research has focused on understanding the pathogenesis of amyotrophic lateral sclerosis (ALS) including the role of altered RNA metabolism in its genesis in addition to defining a role for altered tau metabolism in the frontotemporal spectrum disorder of ALS. He has published over 260 peer-reviewed articles\, edited 4 textbooks and given over 200 invited lectures on these topics. He is the only Canadian to be the recipient of both Sheila Essay Award and the Forbes Norris Award for his care of ALS patients and his research. He was elected as a fellow of the American Academy of Neurology in 2008 and of the Canadian Academy of Health Sciences in 2009. In 2025\, he was awarded the King Charles III Coronation medal.
URL:https://www.centreforbrainhealth.ca/events/dr-michael-j-strong/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
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DTSTART;TZID=America/Vancouver:20261030T110000
DTEND;TZID=America/Vancouver:20261030T120000
DTSTAMP:20260819T202117Z
CREATED:20260326T203619Z
LAST-MODIFIED:20260819T202117Z
UID:17665-1793358000-1793361600@www.centreforbrainhealth.ca
SUMMARY:Dr. Adrien Peyrache: Orienting memory during wake and sleep
DESCRIPTION:The head-direction (HD) circuit\, an upstream provider of orientation signals for navigation\, maintains coherent internal orientation memory that stays stable within each environment for weeks. During non-REM sleep\, when hippocampal trajectories are replayed for memory formation\, HD cells remain coordinated and directly influence this hippocampal replay. This suggests the HD system conveys a “virtual” orientation signal to support memory replay\, with the thalamus appearing to play a crucial role in generating it. Overall\, the HD system supplies the hippocampus and associated structures with a coherent\, possibly lifelong-stable signal maintained across brain states to support spatial navigation and memory formation.
URL:https://www.centreforbrainhealth.ca/events/dr-adrien-peyrache/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
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