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X-WR-CALNAME:Djavad Mowafaghian Centre for Brain Health | DMCBH
X-ORIGINAL-URL:https://www.centreforbrainhealth.ca
X-WR-CALDESC:Events for Djavad Mowafaghian Centre for Brain Health | DMCBH
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DTSTART;TZID=America/Vancouver:20250603T103000
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DTSTAMP:20260527T013910
CREATED:20250601T221252Z
LAST-MODIFIED:20250721T222622Z
UID:16396-1748946600-1748993400@www.centreforbrainhealth.ca
SUMMARY:Dr. Stephen Ferguson: G Protein-coupled Receptors\, Vesicular Glutamate Transporters and β-arrestins as Targets to Attenuate Huntington’s and Alzheimer’s Disease Progression.
DESCRIPTION:Huntington’s disease (HD) and Alzheimer’s disease (AD) are both neurodegenerative disorders that\, despite differing in their underlying causes and specific symptoms\, share several key features. These include age-related onset\, progressive neuronal dysfunction and loss\, cognitive decline\, and a range of behavioral and psychiatric symptoms. Dr. Ferguson’s research presentation will explore the role and sex-specificity of metabotropic glutamate receptor 5 (mGluR5) in the progression and pathology of both HD and AD. In addition\, the presentation will examine the therapeutic potential of alternative targets\, such as vesicular glutamate transporter 3 (VGLUT3)\, M1 muscarinic acetylcholine receptors (M1 mAChR)\, and β-arrestins\, for slowing disease progression and mitigating pathology in these disorders. \n\n\nZoom option if unable to attend in person:\nZoom link here (click on “Join a meeting”)\nMeeting ID: 91512 289258\nPasscode: 289258
URL:https://www.centreforbrainhealth.ca/events/dr-stephen-ferguson-g-protein-coupled-receptors-vesicular-glutamate-transporters-and-%ce%b2-arrestins-as-targets-to-attenuate-huntingtons-and-alzheimers-disease-progression/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
ATTACH;FMTTYPE=image/jpeg:https://www.centreforbrainhealth.ca/wp-content/uploads/2025/05/Stephen-Ferguson.jpeg
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BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20250606T110000
DTEND;TZID=America/Vancouver:20250606T120000
DTSTAMP:20260527T013910
CREATED:20240325T190720Z
LAST-MODIFIED:20250414T194322Z
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SUMMARY:Dr. Charan Ranganath: The boundaries of memory: How cortico-hippocampal interactions at event boundaries support memory and prediction.
DESCRIPTION:Zoom option if unable to attend in person:\nZoom link here (click on “Join a meeting”)\nMeeting ID: 91512 289258\nPasscode: 289258\n\nIn neuroscience\, episodic memory is depicted as a process of activating “engrams” in the hippocampus that provide a static and faithful record of the past. In reality\, behavioral research has established that human memory is dynamic and constructive\, such that we do not replay the past\, but rather\, we rely on prior knowledge about events\, along with a small amount of retrieved information to imagine how the past could have been. Drawing from this work\, I propose a radical alternative to the dominant view in systems neuroscience: Rather than recording every moment of experience\, the brain might reconstruct past events from prior knowledge and a small amount of event-specific information encoded at moments of high uncertainty or prediction error called “event boundaries”. Our data are consistent with the view that the hippocampus and neocortex serve as complementary learning systems\, with the former playing a role in recording snapshots of cortical activity at event boundaries\, and the latter involved in using prior knowledge to understand and reconstruct past events. Beyond episodic memory\, this division of labor might be computationally optimal for spatial navigation\, prediction\, and decision-making.
URL:https://www.centreforbrainhealth.ca/events/dr-charan-ranganath/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
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BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20250613T110000
DTEND;TZID=America/Vancouver:20250613T120000
DTSTAMP:20260527T013910
CREATED:20240531T202837Z
LAST-MODIFIED:20250609T234811Z
UID:13638-1749812400-1749816000@www.centreforbrainhealth.ca
SUMMARY:Dr. Wafaa Zaaraoui: In Vivo ²³Na MRI: Unveiling Sodium Homeostasis in Brain Function and Neurological Disorders
DESCRIPTION:Zoom option if unable to attend in person:\nZoom link here (click on “Join a meeting”)\nMeeting ID: 91512 289258\nPasscode: 289258\n\nSodium (²³Na) MRI is a powerful tool for investigating sodium homeostasis in the brain\, offering a unique\, non-invasive method to study in vivo changes in sodium concentrations in both healthy and pathological conditions. Sodium plays an essential role in brain function by maintaining membrane potentials\, supporting cellular energy metabolism\, and regulating ion gradients – critical processes for neuronal activity and tissue integrity. Disruptions in sodium balance are recognized as key contributors to numerous neurological disorders\, making in vivo ²³Na MRI an innovative and highly valuable technique for advancing neuroscience research. \nThis presentation will emphasize the neuroscientific applications of in vivo ²³Na MRI\, particularly its capacity to reveal sodium imbalances associated with neuroinflammation and neurodegeneration. I will focus on research in multiple sclerosis (MS)\, where altered sodium homeostasis has been explored as a promising biomarker of disease progression and its impact on motor and cognitive function. More broadly\, I will explore how in vivo sodium MRI enhances our understanding of brain pathophysiology and its potential role in a wide range of neurological disorders beyond MS.
URL:https://www.centreforbrainhealth.ca/events/dr-wafaa-zaaraoui/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
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BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20250625T110000
DTEND;TZID=America/Vancouver:20250625T120000
DTSTAMP:20260527T013910
CREATED:20250625T175005Z
LAST-MODIFIED:20250625T175005Z
UID:16213-1750849200-1750852800@www.centreforbrainhealth.ca
SUMMARY:Dr. Guoqiang Bi: Exploring the nervous system across scales: synapse\, brain\, and beyond
DESCRIPTION:Abstract:\nThe brain is a complex system spanning multiple spatiotemporal scales\, from protein molecules organizing into intricate nano-machines in the synapse to many neurons interconnected via synapses to form circuits across the brain. In the past decade\, we have employed and developed various imaging methods to explore this complexity over different scales. At the microscopic scale\, we have employed cryo-electron tomography (cryoET) and correlative light-electron microscopy (CLEM) to visualize ultrastructural features of synapses in their native state\, revealing unique mesophasic organization of neurotransmitter receptors (Nature Neurosci. 23\, 1589\, 2020). At the mesoscopic scale\, we have developed an ultra-high speed volumetric imaging approach\, VISoR\, that enables\, for the first time\, visualization of the whole-brain structure of the rhesus monkey\, revealing unexpected trajectories and complex arborization patterns of individual thalamocortical axons (Nature Biotech. 39\, 1521\, 2021). Beyond the brain\, we have developed a blockface-VISoR system to achieve high-speed imaging of the whole mouse body at micron-resolution\, and to explore previously unattainable features of the peripheral nerve fibers and its interaction with other tissues throughout the entire body (Cell\, in press). \nBio:\nDr. Guo-Qiang Bi is a Xinchuang Professor of Neurobiology and Biophysics and Changjiang Scholar at University of Science and Technology of China (USTC)\, and Director of Interdisciplinary Center for Brain Information at Shenzhen Institute of Advanced Technology\, Chinese Academy of Sciences. He received his B.S. in physics at Peking University\, Ph.D. in biophysics at UC Berkeley and postdoctoral training at UCSD. Before joining USTC\, he was an Associate Professor of Neurobiology at the University of Pittsburgh School of Medicine. His research interest is on the biophysics of neuronal systems\, especially that related to plasticity and learning. His early work revealed computational rules and cellular mechanisms of spike-timing-dependent plasticity (STDP). In recent years\, his lab has been using new imaging tool to explore the cross-scale structure and dynamics of the nervous system\, including in situ molecular organization and dynamics inside synapses\, and brain-wide circuit architecture from mouse to monkey. \n  \n 
URL:https://www.centreforbrainhealth.ca/events/dr-guoqiang-bi-exploring-the-nervous-system-across-scales-synapse-brain-and-beyond/
LOCATION:Koerner Pavilion Conference Centre\, F-106\, 2211 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
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