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X-WR-CALNAME:Djavad Mowafaghian Centre for Brain Health | DMCBH
X-ORIGINAL-URL:https://www.centreforbrainhealth.ca
X-WR-CALDESC:Events for Djavad Mowafaghian Centre for Brain Health | DMCBH
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DTSTART;TZID=America/Vancouver:20240503T110000
DTEND;TZID=America/Vancouver:20240503T120000
DTSTAMP:20260418T115803
CREATED:20230509T191925Z
LAST-MODIFIED:20240213T214218Z
UID:10857-1714734000-1714737600@www.centreforbrainhealth.ca
SUMMARY:Dr. Edward Boyden: Tools for Analyzing and Repairing the Brain
DESCRIPTION:Zoom option if unable to attend in person:\nZoom link here (click on “Join a meeting”)\nMeeting ID: 91512 289258\nPasscode: 289258\n\nUnderstanding and repairing complex biological systems\, such as the brain\, requires technologies for systematically observing and controlling these systems.  We are discovering new molecular principles that enable such technologies.  For example\, we discovered that one can physically magnify biological specimens by synthesizing dense networks of swellable polymer throughout them\, and then chemically processing the specimens to isotropically swell them.  This method\, which we call expansion microscopy\, enables ordinary microscopes to do nanoimaging – important for mapping molecules throughout cells\, and cells throughout brain circuits.  Expansion of biomolecules away from each other also decrowds them\, enabling previously invisible nanostructures to be labeled\, and seen.  As a second example\, we discovered that microbial opsins\, genetically expressed in neurons\, could enable their electrical activities to be precisely controlled in response to light.  These molecules\, called optogenetic tools\, enable causal assessment of how neurons contribute to behaviors and pathological states\, and are yielding insights into new treatment strategies for brain diseases.  They are also beginning to be used in human patients\, in experimental clinical contexts like treating blindness. Finally\, we are developing\, using new strategies such as robotic directed evolution\, fluorescent reporters that enable the precision measurement of signals such as voltage.  In order to reveal relationships between different molecular signals within a cell\, we are developing spatial and temporal multiplexing strategies that enable many such signals to be imaged at once in the same living cell\, using ordinary microscopes\, and requiring only fully genetically encoded constructs.  We share all these tools freely\, and aim to integrate the use of these tools so as to enable comprehensive understandings of neural circuits.
URL:https://www.centreforbrainhealth.ca/events/dr-edward-boyden/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
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BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20240510T110000
DTEND;TZID=America/Vancouver:20240510T120000
DTSTAMP:20260418T115803
CREATED:20230329T202358Z
LAST-MODIFIED:20240314T172754Z
UID:10626-1715338800-1715342400@www.centreforbrainhealth.ca
SUMMARY:Dr. Anne West: From chromatin regulation to synapse development in neurodevelopmental disorders
DESCRIPTION:Zoom option if unable to attend in person:\nZoom link here (click on “Join a meeting”)\nMeeting ID: 91512 289258\nPasscode: 289258\n\nChromatin regulatory proteins are a major class of gene products for which sequence variants are associated with autism spectrum disorders and intellectual disability; however\, the functional consequences of these mutations for brain development remain poorly understood. We are identifying molecular mechanisms through which chromatin regulatory enzymes promote the expression of synaptic gene products and functional neuronal maturation. I will discuss how our studies are working to build a foundation for understanding how dysregulation of chromatin regulation in the developing brain leads to neurodevelopmental disorders.
URL:https://www.centreforbrainhealth.ca/events/dr-anne-west/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20240524T110000
DTEND;TZID=America/Vancouver:20240524T120000
DTSTAMP:20260418T115803
CREATED:20230406T165944Z
LAST-MODIFIED:20240506T180656Z
UID:10695-1716548400-1716552000@www.centreforbrainhealth.ca
SUMMARY:Dr. Brian Corneil: Responding when time is of the essence: a subcortical substrate for rapid visually-guided reaching.
DESCRIPTION:Zoom option if unable to attend in person:\nZoom link here (click on “Join a meeting”)\nMeeting ID: 91512 289258\nPasscode: 289258\n\nHumans operate in a dynamic and uncertain world; sudden changes in an object’s position require rapid changes in motor control. Previous research in humans has shown that on-going visually-guided actions can be altered at latencies that approach minimal afferent and efferent conduction delays. The contribution of such a fast visuomotor system to overall motor control has long been recognized\, but fundamental questions remain about the underlying neural substrates\, and about the comparative contribution of cortical versus subcortical pathways. \nMy talk will focus on converging work on express responses in humans and non-human primates (NHPs). One type of express response is the express saccade\, and another type is what we term an “express visuomotor response”\, which can appear on upper-limb muscles in humans in less than 100 ms\, and in less than 65 ms in animal models. Such remarkably short latencies limit the opportunity for extensive cortical processing\, leading to the hypothesis that express visuomotor responses arise via tecto-reticulo-spinal signalling through the superior colliculus. Ongoing experiments establish that visually-related reaching signals arise within ~50 ms in the movement related layers of the superior colliculus\, which appears early enough to generate express visuomotor responses. These results set the stage for comparative analysis of signal timing in frontal cortical areas. In the final part of my talk\, I will discuss recent findings which show that express visuomotor responses persist in Parkinson’s Disease\, despite degradation of signals related to deliberative reaching. Across all studies\, we are seeing compelling similarities between the properties of express responses and the visual transient in the superior colliculus (SC). Such findings lead us to suggest that a subcortical tecto-reticulo-spinal circuit\, which itself can be primed by cortical inputs\, distributes the earliest visuomotor response that is shared across multiple body effectors.
URL:https://www.centreforbrainhealth.ca/events/dr-brian-corneil/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20240527T153000
DTEND;TZID=America/Vancouver:20240527T170000
DTSTAMP:20260418T115803
CREATED:20240507T234918Z
LAST-MODIFIED:20240507T235008Z
UID:13373-1716823800-1716829200@www.centreforbrainhealth.ca
SUMMARY:The dark arts of naturalistic neuroscience: Using movie-fMRI to study functional brain organization in child psychiatric disorders
DESCRIPTION:This month\, Dr. Tamara Vanderwal from the Department of Psychiatry\, will present “The dark arts of naturalistic neuroscience: Using movie-fMRI to study functional brain organization in child psychiatric disorders.” \nZoom link if unable to attend in person:\nhttps://ubc.zoom.us/j/5747966049?pwd=N1ppY2tUS3o4bk9vTkFSTzBna3k0Zz09 \nMeeting ID: 574 796 6049\nPasscode: 052059
URL:https://www.centreforbrainhealth.ca/events/the-dark-arts-of-naturalistic-neuroscience-using-movie-fmri-to-study-functional-brain-organization-in-child-psychiatric-disorders/
LOCATION:BC Children’s Hospital (BCCHR) Room 2108 (across from Chan Auditorium)\, 938 W 28th Ave\, Vancouver\, BC\, V5Z 4H4
CATEGORIES:Monthly Monday Rounds in Mental Health and Addictions
ATTACH;FMTTYPE=image/jpeg:https://www.centreforbrainhealth.ca/wp-content/uploads/2024/05/Mental-Health-IRP-rounds-May-2024.jpeg
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BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20240531T110000
DTEND;TZID=America/Vancouver:20240531T120000
DTSTAMP:20260418T115803
CREATED:20230328T203831Z
LAST-MODIFIED:20240528T221046Z
UID:10601-1717153200-1717156800@www.centreforbrainhealth.ca
SUMMARY:Dr. Khaled Abdelrahman: Decoding the Intricacies of GPCR Signaling in neurodegenerative diseases
DESCRIPTION:Our research focuses on the intricate role of specific G protein-coupled receptors (GPCRs) in the pathophysiology of neurodegenerative diseases. A key aspect of our focus is unraveling the sex-specific regulation of GPCR signaling in these conditions. Through exploring these intricacies\, we aim to illuminate novel therapeutic avenues and enhance our understanding of the complex interplay between GPCRs and neurodegeneration. \nZoom link: https://ubc.zoom.us/j/67841144478?pwd=K0M9aLiUz8wxKl14bF4giFskCDjMWY.1 \nMeeting ID: 678 4114 4478\nPasscode: 0000
URL:https://www.centreforbrainhealth.ca/events/dr-khaled-abdelrahman/
LOCATION:DMCBH Room 3402\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
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