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DTSTART;TZID=America/Los_Angeles:20220228T153000
DTEND;TZID=America/Los_Angeles:20220228T170000
DTSTAMP:20260501T125814
CREATED:20220210T231708Z
LAST-MODIFIED:20220415T003557Z
UID:8219-1646062200-1646067600@www.centreforbrainhealth.ca
SUMMARY:Round Table: Cluster Member Introductions & Research Plans
DESCRIPTION:This month\, the Mental Health and Addictions IRP will be having a round table where each group member introduces themselves\, an overview of their research\, and their hopes and dreams for future collaborative research. \nZoom link if unable to attend in person: https://ubc.zoom.us/j/5747966049?pwd=N1ppY2tUS3o4bk9vTkFSTzBna3k0Zz09\nMeeting ID: 574 796 6049\nPasscode: 052059
URL:https://www.centreforbrainhealth.ca/events/mental-health-round-table-introductions-research-plans/
LOCATION:DMCBH Room 3402\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Monthly Monday Rounds in Mental Health and Addictions
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20220302T080000
DTEND;TZID=UTC:20220302T130000
DTSTAMP:20260501T125814
CREATED:20220225T201732Z
LAST-MODIFIED:20220228T215632Z
UID:8346-1646208000-1646226000@www.centreforbrainhealth.ca
SUMMARY:BC Neuroscience Day
DESCRIPTION:Schedule:\n8:00 AM – PD Moyes Lecturer for 2022\nPresenter: Dr. Mojgan Hodaie\, MSc\, MD\, FRCSC\, Professor of Surgery\, University of Toronto\nTitle: “An artificial intelligence approach to the study of pain”\nEvaluation: https://ubc.ca1.qualtrics.com/jfe/form/SV_ddmOwxdLlYF4IjI \n9:00 AM\nPresenter: Dr. Neil Cashman\, UBC Professor\, Medicine (Neurology)\nTitle: “Targeting misfolded proteins in neurodegenerative diseases”\nEvaluation: https://ubc.ca1.qualtrics.com/jfe/form/SV_ePcLJdRy2O3b6oC \n10:00 AM\nPresenter: Dr. Cheryl Wellington\, UBC Professor\, Pathology and Laboratory Medicine\nTitle: “The biomarker revolution in neurology”\nEvaluation: https://ubc.ca1.qualtrics.com/jfe/form/SV_bBi7PloMqqkOCLY \n11:00 AM\nPresenter: Dr. Annie Ciernia\, UBC Assistant Professor\, Department of Biochemistry and Molecular Biology\nTitle: “Histone Acetylation Regulates Microglia Innate Immune Memory”\nEvaluation: https://ubc.ca1.qualtrics.com/jfe/form/SV_5prst2xqNGiXR8q \n12:00 PM\nPresenter: Dr. John Maguire\, UBC Professor\, Neuropathology\nTitle: “Clinical Pathological Correlation”\nEvaluation: https://ubc.ca1.qualtrics.com/jfe/form/SV_40EjWHbNZ45nyIu \n  \nLocation: Paetzold auditorium (JPPS 1891 LT) for those wishing to attend in person\, or online via Zoom: \nZoom link: https://ubc.zoom.us/\nMeeting ID: 91037 579420\nPasscode: 579420 \n  \nPlease email Dr. Cashman (Neil.Cashman@vch.ca) with inquiries regarding BC Neuroscience Day programming.
URL:https://www.centreforbrainhealth.ca/events/bc-neuroscience-day/
LOCATION:Paetzold Auditorium\, Vancouver General Hospital\, 899 West 12th Avenue\, Vancouver\, British Columbia\, V5Z 1M9\, Canada
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20220308T130000
DTEND;TZID=America/Los_Angeles:20220308T140000
DTSTAMP:20260501T125814
CREATED:20220223T005627Z
LAST-MODIFIED:20220224T200824Z
UID:8306-1646744400-1646748000@www.centreforbrainhealth.ca
SUMMARY:Danqing Zhu candidate presentation
DESCRIPTION:Gene therapy\, the delivery of genetic material to the cells of a patient for therapeutic benefit\, has been increasingly successful over the past decade. The most successful gene delivery vectors are based on adeno-associated viruses (AAV)\, a naturally derived protein-based and self-assembled ‘nanoparticle’. Although these natural ‘nanoparticles’ are safe and non-pathogenic\, they present several barriers that limit their efficacy in delivery as they were not evolved by nature for human therapeutic applications. Directed evolution\, a strategy involves the iterative genetic diversification of a molecule to create a gene pool and functional selection to isolate variants with optimal properties\, has thereby emerged as a powerful approach for re-evolving AAVs of novel and improved functions. In parallel\, recent advances in deep sequencing technologies allow millions of sequences to be assayed and used for training supervised machine learning (ML) models for prediction of protein properties. Using the combination of directed evolution and ML-guided design\, we have engineered ‘designer’ AAV variants with greatly improved packaging\, diversity\, and primary human brain infection capabilities. Specifically\, we have applied such method for developing AAVs that target a crucial cellular component of the central nervous system (CNS)\, microglia. As a brain-resident macrophage\, microglia unfortunately have been implicated in many neurological diseases\, such as Alzheimer’s disease\, Parkinson’s disease\, Huntington’s disease\, and others etc. Therefore\, genetically manipulating endogenous microglia is a promising therapeutic approach to counteract disease pathology. The extension of such integration of new technologies will have broad utility in the development of next-generation novel AAVs for therapeutic applications of many neurological diseases in the near future. \nZoom link if unable to attend in person: https://ubc.zoom.us/\nMeeting ID: 93332 470044 \nPasscode: 470044 \nFeedback survey for candidate
URL:https://www.centreforbrainhealth.ca/events/danqing-zhu-candidate-presentation/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
ATTACH;FMTTYPE=image/jpeg:https://www.centreforbrainhealth.ca/wp-content/uploads/2022/02/Danqing-Zhu-SBME-candidate-talks.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20220311T110000
DTEND;TZID=America/Vancouver:20220311T120000
DTSTAMP:20260501T125814
CREATED:20210722T000000Z
LAST-MODIFIED:20220301T230646Z
UID:3739-1646996400-1647000000@www.centreforbrainhealth.ca
SUMMARY:Dr. Rutsuko Ito: Ventral hippocampal circuits and the arbitration of approach-avoidance conflict
DESCRIPTION:Approach-avoidance (AA) conflict resolution is a form of decision making that is fundamentally important for survival and requires the effective evaluation of affective stimuli or events with mixed outcomes (positive and negative). Despite the prevailing view of hippocampal involvement in learning and memory processes\, the hippocampus is also thought to be involved in the resolution of AA conflict by exaggerating the value of negative outcomes and increasing the tendency to avoid. Furthermore\, work from my laboratory has implicated the ventral\, but not the dorsal hippocampus\, in mediating affective processes involving learned AA conflict. In this talk\, I will be presenting a set of studies providing evidence of ventral hippocampal (vHPC) mediation of AA decision making when animals are exposed to affectively bivalent (conflicting) cues. I will also present chemogenetic evidence that the control over conflict-elicited AA  behaviours is subfield\, and pathway-specific\, with the investigation extending to the wider extrinsic connectivity of the vHPC with the lateral septum and ventral striatum. \nRudy North Lecture Theatre “Live” Screening\nZoom option if unable to attend in person: \n\nZoom link here (click on “Join a meeting”)\nMeeting ID: 99412 188589\nPasscode: 188589
URL:https://www.centreforbrainhealth.ca/events/dr-rutsuko-ito/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20220314T110000
DTEND;TZID=America/Los_Angeles:20220314T120000
DTSTAMP:20260501T125814
CREATED:20220223T010619Z
LAST-MODIFIED:20220224T201042Z
UID:8311-1647255600-1647259200@www.centreforbrainhealth.ca
SUMMARY:Tatsuya Tsukahara candidate presentation
DESCRIPTION:To interpret the sensory world and select appropriate actions\, animals must distinguish persistent background stimuli from novel sensory cues. Sensory adaptation is a neural mechanism that enables such filtering of environmental stimuli\, and a fundamental feature of sensory systems. Previous studies have shown that the brain flexibly adapt sensory responses to repetitive stimuli through synaptic mechanisms on a timescale of minutes. On the other hand\, the periphery has been generally thought to report sensory information stably and faithfully to the brain\, except for fast adaptation to highly dynamic stimuli on a timescale of milliseconds to seconds. However\, adaptation over longer timescales like hours to days have been largely unexplored\, even though animals typically stay in the same environment over these ethologically relevant timescales. \nI asked if olfactory sensory neurons (OSNs) in the mouse nose adapt to environmental stimuli over timescales of hours to days. Given each mouse OSN expresses only one odorant receptor out of more than 1\,000\, individual receptor-defined OSN subtypes experience a wide range of odor-evoked activity in each environment. Using single cell RNA-sequencing\, I showed that each of the ~1\,000 OSN subtypes harbors a distinct transcriptome whose content is precisely determined by interactions between its expressed odorant receptor and the environment. This transcriptional variation is systematically organized to support sensory adaptation: expression levels of more than 70 genes relevant to transforming odors into spikes continuously vary across OSN subtypes\, dynamically adjust to new environments over hours\, and accurately predict acute OSN-specific odor responses. Importantly\, population-level odor codes delivered to the brain are also modulated by the environment\, as assessed by in vivo calcium imaging of OSN axons. The sensory periphery therefore separates salient signals from predictable background via a transcriptional mechanism whose moment-to-moment state reflects the past and constrains the future. I will further present my future research plan to study how signals from the external and internal world are integrated via transcriptional adaptation and influence the activity in central circuits and odor perception. This research program will provide support for a general model of how animals use individual experience to optimize neural functions and behavior. \nZoom link if unable to attend in person: https://ubc.zoom.us/\nMeeting ID: 91783 244698 \nPasscode: 244698 \nFeedback survey for candidate
URL:https://www.centreforbrainhealth.ca/events/tatsuya-tsukahara-candidate-presentation/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
ATTACH;FMTTYPE=image/jpeg:https://www.centreforbrainhealth.ca/wp-content/uploads/2022/02/Tatsuya-Tsukahara-SBME-candidate-talks.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20220318T110000
DTEND;TZID=America/Vancouver:20220318T120000
DTSTAMP:20260501T125814
CREATED:20210722T000000Z
LAST-MODIFIED:20220304T235750Z
UID:3740-1647601200-1647604800@www.centreforbrainhealth.ca
SUMMARY:Dr. Kate Wassum: Amygdala circuitry in reward learning and decision making
DESCRIPTION:To make adaptive decisions we must cast ourselves into the future and consider the outcomes of our potential choices. This prospective consideration is informed by our memories. I will discuss our lab’s recent work investigating the neural circuits responsible for encoding\, updating\, and retrieving reward memories for use in the considerations underlying decision making. We have taken a multifaceted approach to these investigations\, combining recording\, modern circuit dissection\, and behavioral tools. Our results are generally indicating that the basolateral amygdala\, midbrain\, and orbitofrontal cortex work in a circuit to participate in these functions. The cognitive symptoms underlying many psychiatric disorders result from a failure to appropriately learn about and/or anticipate potential future events\, making these basic science data relevant to the understanding and potential treatment of mental illness. \nZoom option if unable to attend in person: \n\nZoom link here (click on “Join a meeting”)\nMeeting ID: 99412 188589\nPasscode: 188589
URL:https://www.centreforbrainhealth.ca/events/dr-kate-wassum/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20220318T120000
DTEND;TZID=America/Vancouver:20220318T130000
DTSTAMP:20260501T125814
CREATED:20220223T230149Z
LAST-MODIFIED:20220318T232420Z
UID:8292-1647604800-1647608400@www.centreforbrainhealth.ca
SUMMARY:Science Communication Career Workshop
DESCRIPTION:Are you interested in science communication as a career but aren’t sure how to make it happen? Join the Djavad Mowafaghian Centre for Brain Health and the Women’s Health Research Cluster on March 18th\, from 12-1pm to learn more! This event will feature a panel of three science communicators\, all with diverse backgrounds\, who will be sharing their insights and experience in their science communication journey. This event is open to anyone who is interested in learning more about a career in scicomm.  \n  \nRSVP:\nPlease RSVP and include any questions for the panelists: RSVP HERE \nThis event will be held online: Zoom link \n  \nSpeakers:\n \nKate Shingler\nKate Shingler is a skilled communications professional with a penchant for strong espresso and Irish mystery novels. Kate began her career as a journalist at the Sherbrooke Record before moving to the broadcast realm as a local television reporter in Quebec City. She spent a decade at Global TV\, covering daily news\, as a show producer for the noon and evening news and as assistant news director of Global Montreal before moving on to work in public relations for non-profits close to her heart. She led the digital communications team at the McGill University Health Centre Foundation\, where she worked to support the hospital’s priorities and raise funds for compassionate patient care\, excellence in teaching and innovative research. \nIn 2020 Kate joined Brain Canada Foundation as Director of Marketing and Communications\, where she uses impact storytelling\, creative team building and community engagement to underline the critical need for investment in brain research in Canada. One in three Canadians will experience a brain disorder in their lifetime\, and one in five will experience a mental illness or addiction concern. With Brain Canada’s one brain-one community approach\, Kate is a proud member of a dedicated group of individuals committed to accelerating neuroscience across the country for global impact. \nKate is an active community volunteer with a commitment to supporting children in underserved populations. She sits on the boards of the Fraser-Hickson Institute and the Weredale Foundation\, and lives in Montreal with her husband\, their three children and a small dog named Charlotte. \nConnect with Kate on social media! \n\nTwitter\nLinkedIn\n\n  \n \nNoeen Malik\nNoeen Malik\, PhD\, is the nuclear medicine scientist (specialization: drug discovery and PET/CT imaging)\, a published author (The PET Method: Tracer Principle\, Radiochemistry and Medical Applications); business strategist (specialization: Theragnostics)\, Executive Director of Public Affairs at GIANT (Global Immunization Action Networking Team; with WHO-UN)\, California\, and Research Scientist in MIPS\, Stanford School of Medicine. \nShe also volunteers as a human rights activist (Amnesty International\, IRC (International rescue committee)\, and IYC-UN) and fundraiser (SOS Children’s Village). She has also started a philanthropy program under Scientudio’s umbrella\, “Endorse Hope“\, with focusing especially on under-developed countries to help in strengthening the internal personnel-capacities. She is also a cartoonist (Science Myths Playing Deck: Concept and artwork) and science illustrator and communicator. \nConnect with Noeen on social media! \n\nTwitter\nLinkedIn\n\n  \n \nAarthi Gobinath\nAarthi Gobinath is currently a Associate Scientific Director at MedThink SciCom\, supporting medical communications for pharmaceutical companies developing therapeutics for infectious diseases and rare diseases. Previously\, she worked as a Science Writer for the medical device company Ava Women and as a freelance writer. She completed her PhD in Neuroscience at the University of British Columbia\, where she initially began gaining experience and interest in science communication. \nConnect with Aarthi on social media! \n\nTwitter\nLinkedIn
URL:https://www.centreforbrainhealth.ca/events/science-communication-career-workshop/
LOCATION:Online
ATTACH;FMTTYPE=image/png:https://www.centreforbrainhealth.ca/wp-content/uploads/2022/02/Sci-Comms-Career-Workshop-Twitter-General.png
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20220321T110000
DTEND;TZID=America/Los_Angeles:20220321T120000
DTSTAMP:20260501T125814
CREATED:20220224T010946Z
LAST-MODIFIED:20220225T205037Z
UID:8314-1647860400-1647864000@www.centreforbrainhealth.ca
SUMMARY:Majid Mohajerani candidate presentation
DESCRIPTION:Spontaneous activity accounts for most of what the brain does and is likely to be key for information processing in the brain\, but its function is still quite mysterious. Two key spontaneous activity processes are the Default Mode Network (DMN)\, a set of areas that are most markedly connected and active during behavioural idleness\, and memory replay\, the spontaneous reactivation of neural patterns occurring during experience. In the Mohajerani lab\, we test the hypothesis that the DMN plays a key role in memory replay processes. This theory\, if confirmed\, would bring important conceptual advances: to memory studies\, as it would provide a mechanism supporting the formation and consolidation of complex memory representations. I will explore this theory by our ongoing studies of neural activity over the whole mouse cortex in animals running memory tasks. \nZoom link if unable to attend in person: https://ubc.zoom.us/\nMeeting ID: 92458 122636 \nPasscode: 122636  \nFeedback survey for candidate
URL:https://www.centreforbrainhealth.ca/events/majid-mohajerani-candidate-presentation/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
ATTACH;FMTTYPE=image/jpeg:https://www.centreforbrainhealth.ca/wp-content/uploads/2022/02/Majid-Mohajerani-SBME-candidate-talks.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20220325T110000
DTEND;TZID=America/Vancouver:20220325T120000
DTSTAMP:20260501T125814
CREATED:20210722T000000Z
LAST-MODIFIED:20220304T235814Z
UID:3741-1648206000-1648209600@www.centreforbrainhealth.ca
SUMMARY:Dr. Edward F. Chang: Towards a Speech Neuroprosthetic
DESCRIPTION:Speaking is a unique and defining human behavior.  Over the past decade\, we have focused on deciphering the basic neural code that underlies our ability to speak fluently. \nDuring speech production\, vocal tract movement gestures for all speech sounds are encoded by highly specialized neural activity\, organized as a map\, in the human speech motor cortex.   A major effort is now underway to translate these findings towards building an articulatory-based speech neuroprosthetic device for people who cannot communicate. \n\n\n\nZoom option if unable to attend in person: \n\nZoom link here (click on “Join a meeting”)\nMeeting ID: 99412 188589\nPasscode: 188589
URL:https://www.centreforbrainhealth.ca/events/dr-edward-f-chang/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20220328T154500
DTEND;TZID=America/Los_Angeles:20220328T170000
DTSTAMP:20260501T125814
CREATED:20220318T182227Z
LAST-MODIFIED:20220415T003543Z
UID:8593-1648482300-1648486800@www.centreforbrainhealth.ca
SUMMARY:Heart rate variability (HRV) correlates of functional MRI in humans
DESCRIPTION:This month\, Komal Bharti from the Vila-Rodriguez lab in the Department of Psychiatry will present on “Heart rate variability (HRV) correlates of functional MRI in humans.” \nZoom link if unable to attend in person:  \nhttps://ubc.zoom.us/j/5747966049?pwd=N1ppY2tUS3o4bk9vTkFSTzBna3k0Zz09 \nMeeting ID: 574 796 6049\nPasscode: 052059
URL:https://www.centreforbrainhealth.ca/events/heart-rate-variability-correlates-of-functional-mri-in-humans/
LOCATION:DMCBH Room 3402\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Monthly Monday Rounds in Mental Health and Addictions
ATTACH;FMTTYPE=image/jpeg:https://www.centreforbrainhealth.ca/wp-content/uploads/2022/03/Mental-Health-IRP-rounds-Mar-28.jpg
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