Dr. Shigeki Watanabe: Ultrafast recycling of synaptic vesicles

Rudy North Lecture Theatre, Djavad Mowafaghian Centre for Brain Health 2215 Wesbrook Mall, Vancouver

In 1973 John Heuser and Tom Reese demonstrated that neurotransmitter was released from neurons via the fusion of neurotransmitter-filled vesicles with the cell membrane.  But at the same time, these experiments launched a controversy that is unresolved today – do vesicles collapse into the membrane and are then recycled slowly on the order of 20 […]


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Dr. Pascal Kaeser: Mechanisms and Roles for Fast Dopamine Signaling

Rudy North Lecture Theatre, Djavad Mowafaghian Centre for Brain Health 2215 Wesbrook Mall, Vancouver

Dopamine is a neuromodulator that codes information on various time scales. I will discuss recent progress on the identification of fast release mechanisms for dopamine in the mouse striatum. I will present data on triggering mechanisms of dopamine release and evaluate its roles in striatal regulation. In the long-term, our work will allow for a better understanding of the mechanisms and […]


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Machine Learning Analyses for Antidepressant Response Prediction

DMCBH Room 3402 2215 Wesbrook Mall, Vancouver

This month, Dr. John-Jose Nunez (Department of Psychiatry) will present on "Machine Learning Analyses for Antidepressant Response Prediction." Zoom link if unable to attend in person:  https://ubc.zoom.us/j/5747966049?pwd=N1ppY2tUS3o4bk9vTkFSTzBna3k0Zz09 Meeting ID: 574 796 6049 Passcode: 052059


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Dr. Nelson Spruston: Neurophysiological mechanisms of memory guided behavior

Rudy North Lecture Theatre, Djavad Mowafaghian Centre for Brain Health 2215 Wesbrook Mall, Vancouver

Mammals use a sophisticated, multi-regional memory system to guide behavior. A major goal of neuroscience is to understand the mechanisms—ranging from molecular to cellular to systems—that make this possible. Spruston will describe recent results from his lab using mouse behavior, patch-clamp recording, imaging, and RNA-seq, which collectively seek to elucidate how a diverse and complex […]


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Dr. Elizabeth Heller: Epigenetic regulation of reward pathophysiology

Rudy North Lecture Theatre, Djavad Mowafaghian Centre for Brain Health 2215 Wesbrook Mall, Vancouver

The Heller Lab research program is focused on discovering molecular mechanisms by which epigenetic reprogramming contributes to neuropsychiatric disease. To this end, Dr. Heller pioneered the use of targeted epigenetic editing in brain, to elucidate the precise causal role of histone posttranslational modifications on gene expression and alternative splicing in specific neuronal subpopulations. Dr. Heller […]


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Dr. Takao Hensch: Balancing Brain Plasticity/Stability

Rudy North Lecture Theatre, Djavad Mowafaghian Centre for Brain Health 2215 Wesbrook Mall, Vancouver

Brain function is largely shaped by experience in early life, creating windows of both great opportunity and vulnerability. Our work has focused on the biological basis for such critical periods, identifying both “triggers” and “brakes” on plasticity. Strikingly, the maturation of particular inhibitory circuits is pivotal for the onset timing of these windows. Manipulations of […]


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2022 DMCBH Research Retreat

UBC Okanagan 3333 University Way, Kelowna

We are looking forward to hosting this Research Retreat at UBC Okanagan! This event is open to all DMCBH members, postdoctoral fellows, research associates, PhD and MSc students affiliated with the DMCBH. REGISTRATION:  Please note that registration has now closed. However, there are a limited number of spots remaining - please contact Clement Woo if […]


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How emotional context influences memory for neutral scene details in a non-clinical sample of young adults: Implications for trauma-related disorders

DMCBH Room 3402 2215 Wesbrook Mall, Vancouver

This month, Chantelle Cocquyt from the Palombo Lab in the Department of Psychology will present on "How emotional context influences memory for neutral scene details in a non-clinical sample of young adults: Implications for trauma-related disorders." Zoom link if unable to attend in person:  https://ubc.zoom.us/j/5747966049?pwd=N1ppY2tUS3o4bk9vTkFSTzBna3k0Zz09 Meeting ID: 574 796 6049 Passcode: 052059


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R/RStudio Workshop

Online

Join us Wednesday, July 13th at 3:00 pm for our Intro to R Workshop - Part 2, presented by the UBC Databinge Data Champions Team. Zoom link: https://ubc.zoom.us/s/64233269929 Meeting ID: 642 3326 9929 Passcode:  476508   Who should attend this workshop? ​Trainees who want practice making computationally reproducible workflows Trainees who want to learn how […]


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Dr. Anke Henning: Metabolic MRI at ultra-high fields – from systems architecture to application

Rudy North Lecture Theatre, Djavad Mowafaghian Centre for Brain Health 2215 Wesbrook Mall, Vancouver

Metabolic MRI allows observing energy metabolism, neurotransmission, second messaging, endocrine signaling, antioxidants, protein metabolism and dynamic membrane processes in the human brain. Related quantitative metabolic imaging biomarkers are beneficial for differential diagnostics, monitoring of treatment response and patient stratification in various neurological and psychiatric disorders and yield complementary information to structural and functional imaging. To […]


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Dr. Kim Green: Exploring microglia function in the healthy and Alzheimer’s disease brain

Rudy North Lecture Theatre, Djavad Mowafaghian Centre for Brain Health 2215 Wesbrook Mall, Vancouver

Microglia are the primary immune cell of the brain, but have roles outside of immunity as well as being implicated in the pathogenesis of many CNS disorders. Here I will show how we can use CSF1R inhibitors to control the microglial population in vivo, and elucidate their functions in both the homeostatic and disease brains. […]


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Dr. Eugenii A. (Ilan) Rabiner: Molecular Imaging in CNS drug development

Rudy North Lecture Theatre, Djavad Mowafaghian Centre for Brain Health 2215 Wesbrook Mall, Vancouver

Zoom option if unable to attend in person Zoom link here (click on “Join a meeting”) Meeting ID: 99412 188589 Passcode: 188589 Over the past 25 years the costs of drug development have been rising steeply, with later phases being particularly resource intensive. Molecular imaging (primarily PET) has become an indispensable tool in early phase drug development, […]


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Neuroscience Research Colloquium

The Neuroscience Research Colloquium (NRC), is a series of lectures featuring local and international neuroscientists.