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BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20250314T110000
DTEND;TZID=America/Vancouver:20250314T120000
DTSTAMP:20260315T084747
CREATED:20240322T165733Z
LAST-MODIFIED:20250123T212207Z
UID:13104-1741950000-1741953600@www.centreforbrainhealth.ca
SUMMARY:Dr. Anita Devineni: Neural processing for flexible feeding behaviors in Drosophila
DESCRIPTION:Zoom option if unable to attend in person:\nZoom link here (click on “Join a meeting”)\nMeeting ID: 91512 289258\nPasscode: 289258\n\nHow does the brain process sensory information to generate adaptive behaviors that are innate\, yet flexible? My lab investigates this question in the taste system of the fruit fly Drosophila\, which offers unique tools to study how individual neurons contribute to neural circuit computations and behavior. First\, I will discuss our work using optogenetics\, behavior\, calcium imaging\, and connectomic analyses to investigate how taste circuits transform sensory signals into motor actions. Second\, I will discuss a project that bridges experimental and theoretical approaches to understand how flies make foraging decisions. Through these studies\, we hope to uncover principles of neural processing that generalize across species.
URL:https://www.centreforbrainhealth.ca/events/dr-anita-devineni/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20250321T110000
DTEND;TZID=America/Vancouver:20250321T120000
DTSTAMP:20260315T084747
CREATED:20240502T163129Z
LAST-MODIFIED:20250102T192807Z
UID:13292-1742554800-1742558400@www.centreforbrainhealth.ca
SUMMARY:Dr. Graham Collingridge: Glutamate receptors and synaptic plasticity in health and disease.
DESCRIPTION:Zoom option if unable to attend in person:\nZoom link here (click on “Join a meeting”)\nMeeting ID: 91512 289258\nPasscode: 289258\n\nWorking in the laboratory of the late Hugh McLennan (Department of Physiology\, UBC) Stephen Kehl and I discovered that NMDA receptors trigger the induction of long-term potentiation (LTP) in the hippocampus.  Since these early experiments\, the roles of glutamate receptors and their associated signalling processes have been extensively studied.  I will provide an overview of the mechanisms of synaptic plasticity in the hippocampus and how this information is being used to understand the molecular basis of\, and to develop treatments for\, a wide variety of brain disorders.  In this respect\, I will summarise some of our recent work in the areas of neurodevelopmental\, psychiatric and neurodegenerative diseases.
URL:https://www.centreforbrainhealth.ca/events/dr-graham-collingridge/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20250321T150000
DTEND;TZID=America/Vancouver:20250321T160000
DTSTAMP:20260315T084747
CREATED:20250213T225220Z
LAST-MODIFIED:20250213T225220Z
UID:15527-1742569200-1742572800@www.centreforbrainhealth.ca
SUMMARY:Brittany Docolas: Intranasal administration of estradiol to increase motivation to exercise in rats
DESCRIPTION:Join us for the UBC Behavioural Neuroscience Seminars (BNS)\, a lecture series featuring DMCBH trainees and professors in a casual setting. Talks take place from 3-4 pm every Friday in DMCBH 3402A-C and on Zoom. RSVP is not required. \nThis week’s speaker is Brittany Docolas from the Soma Laboratory. \nZoom link: https://ubc.zoom.us/j/62773707502?pwd=SW9DrCTkXaS2LbDf9TEdVXgOHqTGAq.1 \nMeeting ID: 627 7370 7502\nPasscode: 1234 \nIf you would like to be added to the mailing list to receive reminders each week\, please email Melody Salehzadeh (msalehzadeh@zoology.ubc.ca) and/or Jackson Schumacher (schumacher@psych.ubc.ca).
URL:https://www.centreforbrainhealth.ca/events/brittany-docolas-intranasal-administration-of-estradiol-to-increase-motivation-to-exercise-in-rats/
LOCATION:DMCBH Room 3402\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Behavioural Neuroscience Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20250324T153000
DTEND;TZID=America/Vancouver:20250324T170000
DTSTAMP:20260315T084747
CREATED:20250303T203607Z
LAST-MODIFIED:20250303T203607Z
UID:15599-1742830200-1742835600@www.centreforbrainhealth.ca
SUMMARY:Magnetic Resonance Spectroscopy findings in Bipolar disorder: Do they predict recurrences?
DESCRIPTION:This month\, Dr. Chithra Pream Raju from UBC Psychiatry/Richmond Hospital will present “Magnetic Resonance Spectroscopy findings in Bipolar disorder: Do they predict recurrences?” \nZoom link if unable to attend in person:\nhttps://ubc.zoom.us/j/5936706150?pwd=bWFoeDNGMkk2ZVNOQk9FTFZIT0lZdz09&omn=62102214283 \nMeeting ID: 593 670 6150\nPasscode: 506627
URL:https://www.centreforbrainhealth.ca/events/magnetic-resonance-spectroscopy-findings-in-bipolar-disorder-do-they-predict-recurrences/
LOCATION:DMCBH Room 3402\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Monthly Monday Rounds in Mental Health and Addictions
ATTACH;FMTTYPE=image/jpeg:https://www.centreforbrainhealth.ca/wp-content/uploads/2025/03/Mental-Health-IRP-rounds.jpeg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20250328T110000
DTEND;TZID=America/Vancouver:20250328T120000
DTSTAMP:20260315T084747
CREATED:20240326T182334Z
LAST-MODIFIED:20250103T192355Z
UID:13113-1743159600-1743163200@www.centreforbrainhealth.ca
SUMMARY:Dr. Anne Churchland: Movements and engagement during perceptual decision-making
DESCRIPTION:Zoom option if unable to attend in person:\nZoom link here (click on “Join a meeting”)\nMeeting ID: 91512 289258\nPasscode: 289258\n\nSwitching between cognitive states is a natural tendency\, even for trained experts. To test how cognitive state impacts the relationship between neural activity and behavior\, we measured cortex-wide neural activity during decision-making in mice. Task variables and instructed movements elicited similar neural responses regardless of state\, but the neural activity associated with spontaneous\, uninstructed movements became highly variable during disengagement. Surprisingly\, this heightened variability was not due to an increase in movements: behavioral videos showed equally frequent movements in both cognitive states. But while the movement frequency remained similar\, movement timing changed: as animals slipped into disengagement\, their movements became erratically timed. These idiosyncratic movements were a strong predictor of task performance and drove increased variance in neural activity. Our results argue that movements constitute an embodied signature of cognitive state. These observations lay the foundation for future large-scale recording experiments in freely moving animals that we will conduct using novel tools that we have recently developed.
URL:https://www.centreforbrainhealth.ca/events/dr-anne-churchland/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20250328T150000
DTEND;TZID=America/Vancouver:20250328T160000
DTSTAMP:20260315T084747
CREATED:20250213T225313Z
LAST-MODIFIED:20250213T225313Z
UID:15529-1743174000-1743177600@www.centreforbrainhealth.ca
SUMMARY:Anna Mazurenko: Direct measurement of free glucocorticoids in rodent serum using ultrafiltration and LC-MS/MS
DESCRIPTION:Join us for the UBC Behavioural Neuroscience Seminars (BNS)\, a lecture series featuring DMCBH trainees and professors in a casual setting. Talks take place from 3-4 pm every Friday in DMCBH 3402A-C and on Zoom. RSVP is not required. \nThis week’s speaker is Anna Mazurenko from the Soma Laboratory. \nZoom link: https://ubc.zoom.us/j/62773707502?pwd=SW9DrCTkXaS2LbDf9TEdVXgOHqTGAq.1 \nMeeting ID: 627 7370 7502\nPasscode: 1234 \nIf you would like to be added to the mailing list to receive reminders each week\, please email Melody Salehzadeh (msalehzadeh@zoology.ubc.ca) and/or Jackson Schumacher (schumacher@psych.ubc.ca).
URL:https://www.centreforbrainhealth.ca/events/anna-mazurenko-direct-measurement-of-free-glucocorticoids-in-rodent-serum-using-ultrafiltration-and-lc-ms-ms/
LOCATION:DMCBH Room 3402\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Behavioural Neuroscience Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20250403
DTEND;VALUE=DATE:20250404
DTSTAMP:20260315T084747
CREATED:20250327T232952Z
LAST-MODIFIED:20250327T232952Z
UID:15702-1743638400-1743724799@www.centreforbrainhealth.ca
SUMMARY:UBC Giving Day 2025
DESCRIPTION:Join us for the fifth annual UBC Giving Day on Thursday\, April 3. This year\, the Djavad Mowafaghian Centre for Brain Health has been selected as 1 of 4 focus areas for the Faculty of Medicine. \nBrain health is at a critical crossroads—conditions such as Alzheimer’s\, Parkinson’s and depression are on the rise\, yet cutting-edge research remains underfunded. The Centre is dedicated to driving breakthroughs in prevention\, personalized therapies and treatments—but we need your help. \nYour support will advance a new era of brain health by helping researchers fast-track life-changing discoveries that could improve the lives of millions. \nDonate and make your impact today
URL:https://www.centreforbrainhealth.ca/events/ubc-giving-day-2025/
LOCATION:Online
ATTACH;FMTTYPE=image/jpeg:https://www.centreforbrainhealth.ca/wp-content/uploads/2025/03/DMCBH_GD2025_CTA_FipkeNeuroimaging.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20250404T110000
DTEND;TZID=America/Vancouver:20250404T120000
DTSTAMP:20260315T084747
CREATED:20250214T224938Z
LAST-MODIFIED:20250303T190048Z
UID:15549-1743764400-1743768000@www.centreforbrainhealth.ca
SUMMARY:Dr. Sophie Caron: The ecological mind — making sense of the world with a tiny brain
DESCRIPTION:Zoom option if unable to attend in person:\nZoom link here (click on “Join a meeting”)\nMeeting ID: 91512 289258\nPasscode: 289258\n\nBrains are evolved to learn\, enabling animals to respond flexibly to an unpredictable world and to draw on experience to guide future behaviors. To learn efficiently\, brains need to balance a high degree of flexibility in the representation of the outside world with the limited neuronal infrastructure available to them. Focusing on the Drosophila melanogaster olfactory system\, my research investigates how the neuronal circuits that enable efficient learning are pre-configured to interpret the world. In my presentation\, I will explore two key questions: First\, what are the neural pre-configurations that allow the brain to learn efficiently from the environment? Second\, how are these pre-configurations shaped by the ecological conditions in which brains evolve? Using a wide range of approaches — from neurogenetics and behavioral assays to cross-species comparisons and the study of species interactions — we reveal the subtle ways in which ecology shapes neuronal circuit architecture and function. \n 
URL:https://www.centreforbrainhealth.ca/events/dr-sophie-caron/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20250411T110000
DTEND;TZID=America/Vancouver:20250411T120000
DTSTAMP:20260315T084747
CREATED:20240320T234924Z
LAST-MODIFIED:20250102T195134Z
UID:13088-1744369200-1744372800@www.centreforbrainhealth.ca
SUMMARY:Dr. Sandeep Robert Datta: Structure and meaning in natural behavior
DESCRIPTION:Zoom option if unable to attend in person:\nZoom link here (click on “Join a meeting”)\nMeeting ID: 91512 289258\nPasscode: 289258\n\nEthologists describing animals in the wild have long appreciated that naturalistic\, self-motivated behavior is built from modules that are linked together over time into predictable sequences. Many such sequences are built to extract information from the environment. And yet\, it remains unclear how the brain regulates the selection of individual behavioral modules for expression at any given moment\, or how it dynamically composes these modules into the fluid behaviors observed when animals act of their own volition\, and in the absence of experimental restraint\, task structure or explicit reward. Here we use novel methods for characterizing spontaneous mouse behavior — combined with neural recordings and closed-loop manipulations — to reveal mechanisms used by the brain to create the architecture of self-guided behavior. I will describe recent results in which we explain behavioral variation across timescales ranging from milliseconds to millennia.
URL:https://www.centreforbrainhealth.ca/events/dr-sandeep-robert-datta/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20250414T140000
DTEND;TZID=America/Vancouver:20250414T150000
DTSTAMP:20260315T084747
CREATED:20250327T231254Z
LAST-MODIFIED:20250328T223618Z
UID:15697-1744639200-1744642800@www.centreforbrainhealth.ca
SUMMARY:Career Paths in Translational Research (MATRIX-N Trainee Mentorship Session)
DESCRIPTION:In this trainee mentorship session organized by UBC’s MATRIX-N cluster\, a multidisciplinary panel of preclinical\, clinical\, and industry researchers/experts\, including Dr. Catharine Winstanley (UBC Psychology)\, Dr. Brittany Dennis (UBC Psychiatry) and Mr. Karim Lalji (Pharmaceutical Exec)\, will discuss different career paths in translational research and answer your questions. All students\, trainees\, and early-career researchers welcome! Food and refreshments will be provided. \nZoom link:\nhttps://ubc.zoom.us/j/5936706150?pwd=bWFoeDNGMkk2ZVNOQk9FTFZIT0lZdz09&omn=62102214283
URL:https://www.centreforbrainhealth.ca/events/career-paths-in-translational-research-matrix-n-trainee-mentorship-session/
LOCATION:DMCBH Room 3402\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
ATTACH;FMTTYPE=image/png:https://www.centreforbrainhealth.ca/wp-content/uploads/2025/03/MATRIX-N-Career-Paths-in-Translational-Research.png
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20250425T110000
DTEND;TZID=America/Vancouver:20250425T120000
DTSTAMP:20260315T084747
CREATED:20240320T171011Z
LAST-MODIFIED:20250102T193028Z
UID:13073-1745578800-1745582400@www.centreforbrainhealth.ca
SUMMARY:Dr. Simon Chen: Probing the temporal dynamics of noradrenaline release at fine spatial scales during motor learning in healthy and diseased brains
DESCRIPTION:Zoom option if unable to attend in person:\nZoom link here (click on “Join a meeting”)\nMeeting ID: 91512 289258\nPasscode: 289258\n\nNoradrenaline (NA) is a strong modulator of neuronal activity\, and many symptoms in patients with Autism Spectrum Disorder (ASD) can be attributed to the maladaptive activity of locus coeruleus (LC)\, the main source of forebrain NA; hence\, it has garnered much attention as a potential lens through which to view and understand ASD. Our lab recently uncovered a role for dysregulated LC-NA function in motor learning delays in the 16p11.2 deletion mouse model of ASD (Yin et al.\, Nature Neuroscience 2021). We found that reduced NA levels in the primary motor cortex (M1) caused delays in motor learning and increased neuronal activity in pyramidal neurons (PNs) of M1 in 16p11.2 deletion mice. Strikingly\, both the behavioral and neuronal phenotypes were rescued by chemogenetic activation of LC-NA. \nIn order to fully characterize the local dynamic NA levels during learning in the 16p11.2 deletion mice\, we employ a newly developed optical NA sensor\, GRABNE\, with in vivo two-photon imaging to visualize the spatiotemporal release patterns of NA in M1 during motor learning. Intriguingly\, we find that while wild-type (WT) mice exhibit consistently elevated NA levels during movements\, 16p11.2 deletion mice show a delay in behaviorally induced NA increases. In addition to the delay in temporal dynamics\, 16p11.2 deletion mice show altered spatial dynamics\, with sparser and less behavior-specific NA release across M1 during the initial learning. In addition\, we also assess the LC-NA axonal neuronal activity in M1 using in vivo Ca2+ imaging. We also observe that behavior-related activity transients are less reliable in 16p11.2 deletion mice with more unspecific activity transients during the baseline period. Intriguingly\, pharmacological and closed loop optogenetic manipulations that disrupt the spatial and temporal specificity of NA release\, respectively\, in M1 were sufficient to induce delayed motor learning in WT mice. Our results offer new insights into the temporal dynamics of NA release at fine spatial scales within one brain region and how the specificities are critical for motor skill acquisition.
URL:https://www.centreforbrainhealth.ca/events/dr-simon-chen/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20250425T150000
DTEND;TZID=America/Vancouver:20250425T160000
DTSTAMP:20260315T084747
CREATED:20250213T225621Z
LAST-MODIFIED:20250213T225621Z
UID:15535-1745593200-1745596800@www.centreforbrainhealth.ca
SUMMARY:Nikolas Kokan: Understanding the impact of timing on habituation
DESCRIPTION:Join us for the UBC Behavioural Neuroscience Seminars (BNS)\, a lecture series featuring DMCBH trainees and professors in a casual setting. Talks take place from 3-4 pm every Friday in DMCBH 3402A-C and on Zoom. RSVP is not required. \nThis week’s speaker is Nikolas Kokan from the Behavioural Neurogenetics Lab. \nZoom link: https://ubc.zoom.us/j/62773707502?pwd=SW9DrCTkXaS2LbDf9TEdVXgOHqTGAq.1 \nMeeting ID: 627 7370 7502\nPasscode: 1234 \nIf you would like to be added to the mailing list to receive reminders each week\, please email Melody Salehzadeh (msalehzadeh@zoology.ubc.ca) and/or Jackson Schumacher (schumacher@psych.ubc.ca).
URL:https://www.centreforbrainhealth.ca/events/nikolas-kokan-understanding-the-impact-of-timing-on-habituation/
LOCATION:DMCBH Room 3402\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Behavioural Neuroscience Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20250428T153000
DTEND;TZID=America/Vancouver:20250428T170000
DTSTAMP:20260315T084747
CREATED:20250404T222329Z
LAST-MODIFIED:20250404T222428Z
UID:15765-1745854200-1745859600@www.centreforbrainhealth.ca
SUMMARY:Informing treatment strategies for addressing the opioid epidemic using pharmacometrics
DESCRIPTION:This month\, Sahithi Thotakura and Dr. Anil Maharaj from UBC Pharmaceutical Sciences will present “Informing treatment strategies for addressing the opioid epidemic using pharmacometrics.” \nZoom link if unable to attend in person:\nhttps://ubc.zoom.us/j/5936706150?pwd=bWFoeDNGMkk2ZVNOQk9FTFZIT0lZdz09&omn=62102214283 \n 
URL:https://www.centreforbrainhealth.ca/events/informing-treatment-strategies-for-addressing-the-opioid-epidemic-using-pharmacometrics/
LOCATION:DMCBH Room 3402\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Monthly Monday Rounds in Mental Health and Addictions
ATTACH;FMTTYPE=image/jpeg:https://www.centreforbrainhealth.ca/wp-content/uploads/2025/04/Mental-Health-IRP-rounds-April-2025.jpeg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20250502T110000
DTEND;TZID=America/Vancouver:20250502T120000
DTSTAMP:20260315T084747
CREATED:20240419T183828Z
LAST-MODIFIED:20250312T165215Z
UID:13252-1746183600-1746187200@www.centreforbrainhealth.ca
SUMMARY:Dr. Sarah Morrow: Cognition in Multiple Sclerosis:The importance of integrating research findings into clinical practice.
DESCRIPTION:Zoom option if unable to attend in person:\nZoom link here (click on “Join a meeting”)\nMeeting ID: 91512 289258\nPasscode: 289258\n\nThe objectives of this talk are to: \n\nUnderstand the importance of identifying cognitive complaints and cognitive impairment in persons with MS;\nUnderstand the impact cognition can have on persons with MS;\nConsider how cognition symptoms can be addressed in clinical settings
URL:https://www.centreforbrainhealth.ca/events/dr-sarah-morrow/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20250509T110000
DTEND;TZID=America/Vancouver:20250509T120000
DTSTAMP:20260315T084747
CREATED:20240724T164833Z
LAST-MODIFIED:20250416T182621Z
UID:14144-1746788400-1746792000@www.centreforbrainhealth.ca
SUMMARY:Dr. Julie Lefebvre: Molecular strategies for wiring neurons into circuits
DESCRIPTION:Zoom option if unable to attend in person:\nZoom link here (click on “Join a meeting”)\nMeeting ID: 91512 289258\nPasscode: 289258\n\nA critical step in neural circuit assembly is the integration of inhibitory interneurons with exquisite specificity in their numbers\, distribution and synaptic connectivity. Our lab aims to identify cellular and molecular mechanisms that generate interneuron diversity and specify their precise wiring patterns in retinal and brain circuits in mouse models. I will present our work on the roles of Cadherin superfamily recognition molecules in regulating inhibitory interneuron development and wiring\, as well as a toolkit we are developing to map trans-neuronal interactions and connectivity in vivo. 
URL:https://www.centreforbrainhealth.ca/events/dr-julia-lefebvre/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20250516T110000
DTEND;TZID=America/Vancouver:20250516T120000
DTSTAMP:20260315T084747
CREATED:20250107T183351Z
LAST-MODIFIED:20250214T223626Z
UID:15212-1747393200-1747396800@www.centreforbrainhealth.ca
SUMMARY:Dr. Cheryl Wellington: New CFI funded Core Facility
DESCRIPTION:Zoom option if unable to attend in person:\nZoom link here (click on “Join a meeting”)\nMeeting ID: 91512 289258\nPasscode: 289258\n\nDr. Wellington will be introducing a new CFI funded Core Facility that will focus on fluid biomarkers relevant to clinical neurology and fundamental neuroscience.
URL:https://www.centreforbrainhealth.ca/events/dr-cheryl-wellington-2/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20250526T153000
DTEND;TZID=America/Vancouver:20250526T170000
DTSTAMP:20260315T084747
CREATED:20250514T193230Z
LAST-MODIFIED:20250514T193230Z
UID:15967-1748273400-1748278800@www.centreforbrainhealth.ca
SUMMARY:KK-103\, a novel prodrug of leu-enkephalin for antinociception and mood-improving
DESCRIPTION:This month\, Dr. Shyh-Dar Li from UBC Pharmaceutical Sciences will present “KK-103\, a novel prodrug of leu-enkephalin for antinociception and mood-improving.” \nZoom link if unable to attend in person:\nhttps://ubc.zoom.us/j/5936706150?pwd=bWFoeDNGMkk2ZVNOQk9FTFZIT0lZdz09&omn=62102214283 \n 
URL:https://www.centreforbrainhealth.ca/events/kk-103-a-novel-prodrug-of-leu-enkephalin-for-antinociception-and-mood-improving/
LOCATION:DMCBH Room 3402\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Monthly Monday Rounds in Mental Health and Addictions
ATTACH;FMTTYPE=image/jpeg:https://www.centreforbrainhealth.ca/wp-content/uploads/2025/05/Mental-Health-IRP-rounds-May-2025.jpeg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20250530T110000
DTEND;TZID=America/Vancouver:20250530T120000
DTSTAMP:20260315T084747
CREATED:20240503T164757Z
LAST-MODIFIED:20250128T190851Z
UID:13308-1748602800-1748606400@www.centreforbrainhealth.ca
SUMMARY:Dr. Pinar Ayata: Neurodegenerative functions of microglia in Alzheimer's disease
DESCRIPTION:Zoom option if unable to attend in person:\nZoom link here (click on “Join a meeting”)\nMeeting ID: 91512 289258\nPasscode: 289258\n\nThe brain’s primary immune cells\, microglia\, are a leading causal cell type in Alzheimer’s disease (AD). Yet\, the mechanisms by which microglia can drive neurodegeneration remain unresolved. Here\, we discover that a conserved stress signaling pathway\, the integrated stress response (ISR)\, characterizes a microglia subset with neurodegenerative outcomes. Autonomous activation of ISR in microglia is sufficient to induce early features of the ultrastructurally distinct “dark microglia” linked to pathological synapse loss. In AD models\, microglial ISR activation exacerbates neurodegenerative pathologies and synapse loss while its inhibition ameliorates them. Mechanistically\, we present evidence that ISR activation promotes the secretion of toxic lipids by microglia\, impairing neuron homeostasis and survival in vitro. Accordingly\, pharmacological inhibition of ISR or lipid synthesis mitigates synapse loss in AD models. Our results demonstrate that microglial ISR activation represents a neurodegenerative phenotype\, which may be sustained\, at least in part\, by the secretion of toxic lipids.
URL:https://www.centreforbrainhealth.ca/events/dr-pinar-ayata/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20250603T103000
DTEND;TZID=America/Vancouver:20250603T233000
DTSTAMP:20260315T084747
CREATED:20250601T221252Z
LAST-MODIFIED:20250721T222622Z
UID:16396-1748946600-1748993400@www.centreforbrainhealth.ca
SUMMARY:Dr. Stephen Ferguson: G Protein-coupled Receptors\, Vesicular Glutamate Transporters and β-arrestins as Targets to Attenuate Huntington’s and Alzheimer’s Disease Progression.
DESCRIPTION:Huntington’s disease (HD) and Alzheimer’s disease (AD) are both neurodegenerative disorders that\, despite differing in their underlying causes and specific symptoms\, share several key features. These include age-related onset\, progressive neuronal dysfunction and loss\, cognitive decline\, and a range of behavioral and psychiatric symptoms. Dr. Ferguson’s research presentation will explore the role and sex-specificity of metabotropic glutamate receptor 5 (mGluR5) in the progression and pathology of both HD and AD. In addition\, the presentation will examine the therapeutic potential of alternative targets\, such as vesicular glutamate transporter 3 (VGLUT3)\, M1 muscarinic acetylcholine receptors (M1 mAChR)\, and β-arrestins\, for slowing disease progression and mitigating pathology in these disorders. \n\n\nZoom option if unable to attend in person:\nZoom link here (click on “Join a meeting”)\nMeeting ID: 91512 289258\nPasscode: 289258
URL:https://www.centreforbrainhealth.ca/events/dr-stephen-ferguson-g-protein-coupled-receptors-vesicular-glutamate-transporters-and-%ce%b2-arrestins-as-targets-to-attenuate-huntingtons-and-alzheimers-disease-progression/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
ATTACH;FMTTYPE=image/jpeg:https://www.centreforbrainhealth.ca/wp-content/uploads/2025/05/Stephen-Ferguson.jpeg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20250606T110000
DTEND;TZID=America/Vancouver:20250606T120000
DTSTAMP:20260315T084747
CREATED:20240325T190720Z
LAST-MODIFIED:20250414T194322Z
UID:13111-1749207600-1749211200@www.centreforbrainhealth.ca
SUMMARY:Dr. Charan Ranganath: The boundaries of memory: How cortico-hippocampal interactions at event boundaries support memory and prediction.
DESCRIPTION:Zoom option if unable to attend in person:\nZoom link here (click on “Join a meeting”)\nMeeting ID: 91512 289258\nPasscode: 289258\n\nIn neuroscience\, episodic memory is depicted as a process of activating “engrams” in the hippocampus that provide a static and faithful record of the past. In reality\, behavioral research has established that human memory is dynamic and constructive\, such that we do not replay the past\, but rather\, we rely on prior knowledge about events\, along with a small amount of retrieved information to imagine how the past could have been. Drawing from this work\, I propose a radical alternative to the dominant view in systems neuroscience: Rather than recording every moment of experience\, the brain might reconstruct past events from prior knowledge and a small amount of event-specific information encoded at moments of high uncertainty or prediction error called “event boundaries”. Our data are consistent with the view that the hippocampus and neocortex serve as complementary learning systems\, with the former playing a role in recording snapshots of cortical activity at event boundaries\, and the latter involved in using prior knowledge to understand and reconstruct past events. Beyond episodic memory\, this division of labor might be computationally optimal for spatial navigation\, prediction\, and decision-making.
URL:https://www.centreforbrainhealth.ca/events/dr-charan-ranganath/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20250613T110000
DTEND;TZID=America/Vancouver:20250613T120000
DTSTAMP:20260315T084747
CREATED:20240531T202837Z
LAST-MODIFIED:20250609T234811Z
UID:13638-1749812400-1749816000@www.centreforbrainhealth.ca
SUMMARY:Dr. Wafaa Zaaraoui: In Vivo ²³Na MRI: Unveiling Sodium Homeostasis in Brain Function and Neurological Disorders
DESCRIPTION:Zoom option if unable to attend in person:\nZoom link here (click on “Join a meeting”)\nMeeting ID: 91512 289258\nPasscode: 289258\n\nSodium (²³Na) MRI is a powerful tool for investigating sodium homeostasis in the brain\, offering a unique\, non-invasive method to study in vivo changes in sodium concentrations in both healthy and pathological conditions. Sodium plays an essential role in brain function by maintaining membrane potentials\, supporting cellular energy metabolism\, and regulating ion gradients – critical processes for neuronal activity and tissue integrity. Disruptions in sodium balance are recognized as key contributors to numerous neurological disorders\, making in vivo ²³Na MRI an innovative and highly valuable technique for advancing neuroscience research. \nThis presentation will emphasize the neuroscientific applications of in vivo ²³Na MRI\, particularly its capacity to reveal sodium imbalances associated with neuroinflammation and neurodegeneration. I will focus on research in multiple sclerosis (MS)\, where altered sodium homeostasis has been explored as a promising biomarker of disease progression and its impact on motor and cognitive function. More broadly\, I will explore how in vivo sodium MRI enhances our understanding of brain pathophysiology and its potential role in a wide range of neurological disorders beyond MS.
URL:https://www.centreforbrainhealth.ca/events/dr-wafaa-zaaraoui/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20250625T110000
DTEND;TZID=America/Vancouver:20250625T120000
DTSTAMP:20260315T084747
CREATED:20250625T175005Z
LAST-MODIFIED:20250625T175005Z
UID:16213-1750849200-1750852800@www.centreforbrainhealth.ca
SUMMARY:Dr. Guoqiang Bi: Exploring the nervous system across scales: synapse\, brain\, and beyond
DESCRIPTION:Abstract:\nThe brain is a complex system spanning multiple spatiotemporal scales\, from protein molecules organizing into intricate nano-machines in the synapse to many neurons interconnected via synapses to form circuits across the brain. In the past decade\, we have employed and developed various imaging methods to explore this complexity over different scales. At the microscopic scale\, we have employed cryo-electron tomography (cryoET) and correlative light-electron microscopy (CLEM) to visualize ultrastructural features of synapses in their native state\, revealing unique mesophasic organization of neurotransmitter receptors (Nature Neurosci. 23\, 1589\, 2020). At the mesoscopic scale\, we have developed an ultra-high speed volumetric imaging approach\, VISoR\, that enables\, for the first time\, visualization of the whole-brain structure of the rhesus monkey\, revealing unexpected trajectories and complex arborization patterns of individual thalamocortical axons (Nature Biotech. 39\, 1521\, 2021). Beyond the brain\, we have developed a blockface-VISoR system to achieve high-speed imaging of the whole mouse body at micron-resolution\, and to explore previously unattainable features of the peripheral nerve fibers and its interaction with other tissues throughout the entire body (Cell\, in press). \nBio:\nDr. Guo-Qiang Bi is a Xinchuang Professor of Neurobiology and Biophysics and Changjiang Scholar at University of Science and Technology of China (USTC)\, and Director of Interdisciplinary Center for Brain Information at Shenzhen Institute of Advanced Technology\, Chinese Academy of Sciences. He received his B.S. in physics at Peking University\, Ph.D. in biophysics at UC Berkeley and postdoctoral training at UCSD. Before joining USTC\, he was an Associate Professor of Neurobiology at the University of Pittsburgh School of Medicine. His research interest is on the biophysics of neuronal systems\, especially that related to plasticity and learning. His early work revealed computational rules and cellular mechanisms of spike-timing-dependent plasticity (STDP). In recent years\, his lab has been using new imaging tool to explore the cross-scale structure and dynamics of the nervous system\, including in situ molecular organization and dynamics inside synapses\, and brain-wide circuit architecture from mouse to monkey. \n  \n 
URL:https://www.centreforbrainhealth.ca/events/dr-guoqiang-bi-exploring-the-nervous-system-across-scales-synapse-brain-and-beyond/
LOCATION:Koerner Pavilion Conference Centre\, F-106\, 2211 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20250703T110000
DTEND;TZID=America/Vancouver:20250703T120000
DTSTAMP:20260315T084747
CREATED:20250625T174024Z
LAST-MODIFIED:20250625T174259Z
UID:16209-1751540400-1751544000@www.centreforbrainhealth.ca
SUMMARY:Dr. Jonathan Epp: Resilience and Risk: How Sex Differences in Inhibitory Networks Shape Alzheimer’s Disease Trajectories
DESCRIPTION:Recent work from our lab has focused on understanding the function of the retrosplenial cortex (RSC) in both health and disease. This region plays a critical role in supporting cognitive functions such as memory integration and spatial navigation and is also one of the earliest sites of dysfunction in Alzheimer’s disease. By investigating the cellular and circuit mechanisms underlying RSC activity\, we aim to uncover how vulnerability emerges and how it might be reversed. \nI will present recent findings that converge on a cohesive narrative: intrinsic sex differences in inhibitory circuits shape baseline resilience and set the stage for differential vulnerability to disease. In both Alzheimer’s disease models and human patients\, early dysfunction and loss of PV⁺ interneurons in the RSC lead to circuit instability\, disrupted network dynamics\, and memory deficits. Yet\, this vulnerability is not irreversible. Targeted interventions ranging from circuit-level manipulations to environmental enrichment can restore inhibitory balance and rescue cognitive function. Together\, this work outlines a sex-informed\, circuit-based framework for understanding the earliest stages of Alzheimer’s disease and offers a roadmap for developing more personalized strategies for prevention and intervention. \n  \nBio: \nDr. Jonathan Epp has expertise in microscopy\, histology and behavioural neuroscience. Dr. Epp was hired in 2017 as an Assistant Professor in the Department of Cell Biology and Anatomy and a full member of the HBI at UCalgary. His background in neuroscience was shaped by his training with several world leaders in behavioural neuroscience\, adult neurogenesis and learning and memory. He received his B.Sc. and M.Sc. in neuroscience from the University of Lethbridge\, Canadian Center for Behavioral Neuroscience with Dr. Robert Sutherland\, (1999-2003; 2003-2005) His Ph.D. was completed at the University of British Columbia in 2010 with Dr. Liisa Galea. Dr. Epp conducted postdoctoral work at the Hospital for Sick Children in Toronto with Dr. Paul Frankland where he was the recipient of funding from several sources including the Ontario ministry of research and innovation and was granted a prestigious NARSAD young investigator award from the Brain and behavior research foundation. Dr. Epp has expertise in adult neurogenesis\, structural and functional integration of new neurons and has performed numerous studies examining hippocampal function in both rodent models and in humans. He has recently demonstrated the functional importance of adult neurogenesis in forgetting and how this mechanism protects against memory interference. His current work is focused on examining brain-wide structural and functional connectivity changes that mediate learning\, memory and forgetting. Recently\, Dr. Epp has become a leader in the field of tissue clearing\, a novel research area that has allowed for unique insight into the 3-dimensional organization of intact brain tissue. His recent work has resulted in the development of protocols for tissue clearing and analysis of intact neuronal morphology and brain wide functional networks. Dr. Epp has published extensively with 28 peer-reviewed papers in high impact journals such as Nature communications\, Neuron and Journal of neuroscience.
URL:https://www.centreforbrainhealth.ca/events/dr-jonathan-epp-resilience-and-risk-how-sex-differences-in-inhibitory-networks-shape-alzheimers-disease-trajectories/
LOCATION:DMCBH Room 3402\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20250731T130000
DTEND;TZID=America/Vancouver:20250731T140000
DTSTAMP:20260315T084747
CREATED:20250721T000304Z
LAST-MODIFIED:20250725T005639Z
UID:15958-1753966800-1753970400@www.centreforbrainhealth.ca
SUMMARY:Dr. Gerald Obermair: Presynaptic α2δ proteins: calcium channels\, synaptic functions\, and pathophysiological roles in neurodevelopmental disorders
DESCRIPTION:We are delighted to host Dr. Gerald Obermair\, a well-known neuroscientist from Karl Landsteiner University\, Krems\, Austria who will be visiting on Thursday\, July 31. \nSeminar summary: \nVoltage-gated calcium channels (VGCCs) are essential regulators of cellular excitability and synaptic communication. Among their auxiliary subunits\, the α2δ proteins play a pivotal role in regulating channel expression\, biophysical properties\, and synaptic functions. Clinically\, α2δ proteins are the target of gabapentinoids\, Gabapentin and Pregabalin\, therapeutics use in the treatment of neuropathic pain\, restless leg syndrome\, epilepsy and generalized anxiety disorder. This presentation focuses on the presynaptic functions of α2δ proteins\, particularly α2δ-2 and α2δ-3\, and presents insights into their role in neurodevelopmental and neuropsychiatric disorders. \nExperimental data from knockout and rescue models reveal that α2δ proteins are key organizers of excitatory glutamatergic synapses\, with highly redundant roles across isoforms. Presynaptic expression of a specific α2δ-2 splice variant modulates postsynaptic GABA receptor abundance and synaptic wiring\, independent of the interaction with calcium channels. Mutations in CACNA2D genes are linked to a spectrum of disorders including epileptic encephalopathy\, autism\, and schizophrenia. Functional analyses of specific mutations (e.g.\, R596P and G303V in α2δ-2) demonstrate altered calcium signaling\, impaired synaptic targeting\, and disrupted trans-synaptic communication. Moreover\, behavioral and electrophysiological studies in α2δ-3 knockout mice further support the role of α2δ proteins in shaping neuronal connectivity and plasticity. \nThese findings underscore the dual role of α2δ proteins in channel-dependent and independent mechanisms\, highlighting their contribution to both channelopathies and synaptopathies. Understanding these pathways offers promising avenues for future therapeutic intervention in neurodevelopmental disorders.
URL:https://www.centreforbrainhealth.ca/events/dr-gerald-obermair-presynaptic-%ce%b12%ce%b4-proteins-calcium-channels-synaptic-functions-and-pathophysiological-roles-in-neurodevelopmental-disorders/
LOCATION:DMCBH Room 3402\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
ATTACH;FMTTYPE=image/jpeg:https://www.centreforbrainhealth.ca/wp-content/uploads/2025/05/Dr.-Gerald-Obermair.jpeg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20250910T170000
DTEND;TZID=UTC:20250910T180000
DTSTAMP:20260315T084747
CREATED:20250812T174147Z
LAST-MODIFIED:20250812T175602Z
UID:16556-1757523600-1757527200@www.centreforbrainhealth.ca
SUMMARY:Neuropizza with the Rankin lab
DESCRIPTION:Come and learn about some cool science and hang out with your neuroscience colleagues over pizza and drinks!! Neuropizza takes place monthly in the Koerner conference room starting at 5:00pm and is open to everyone.
URL:https://www.centreforbrainhealth.ca/events/neuropizza-with-the-rankin-lab/
LOCATION:Koerner Pavilion Conference Centre\, F-106\, 2211 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuropizza
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20250912T110000
DTEND;TZID=America/Vancouver:20250912T120000
DTSTAMP:20260315T084747
CREATED:20250417T180401Z
LAST-MODIFIED:20250729T164603Z
UID:15834-1757674800-1757678400@www.centreforbrainhealth.ca
SUMMARY:Dr. Bence Olveczky: Neural circuits underlying learned motor sequences.
DESCRIPTION:Our ability to sequence movements and actions in response to unpredictable environmental events underlies our rich and adaptive behavioral repertoire. Such flexible behaviors contrast with overtrained\, or automatic\, motor sequences directed at specific tasks and executed the same way every time. We probed how neural circuits underlie these distinct forms of motor sequence execution by training rats on a ‘piano task’ in which the same motor sequence can be generated in response to unpredictable cues or overtrained to the point of automaticity. By measuring and manipulating neural activity in motor cortex and sensorimotor striatum\, we delineate the logic by which these circuits combine to generate both flexible and automatic motor sequences.
URL:https://www.centreforbrainhealth.ca/events/dr-bence-olveczky/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20250919T110000
DTEND;TZID=America/Vancouver:20250919T120000
DTSTAMP:20260315T084747
CREATED:20250417T181034Z
LAST-MODIFIED:20250731T173317Z
UID:15838-1758279600-1758283200@www.centreforbrainhealth.ca
SUMMARY:Dr. Matthew Hill: Amygdalar Regulation of Neuroendocrine and Behavioral Responses to Threat and Stress
DESCRIPTION:While the basolateral amygdala (BLA)  is known to be a highly stress sensitive region of the brain\, there is surprisingly little understanding of the role the BLA plays in the orchestration of a stress response. The first portion of this talk will focus on the role of the BLA in regulating neuroendocrine responses to stress\, and how differential projection neuron populations in the BLA are stress sensitive and have diverse anatomical organization. The second arm of this talk will examine the role of the BLA in modulating behavioral responses\, in a sex specific manner\, to a dynamic threat based environment with a robotic predator.
URL:https://www.centreforbrainhealth.ca/events/dr-matthew-hill/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20250922T153000
DTEND;TZID=America/Vancouver:20250922T170000
DTSTAMP:20260315T084747
CREATED:20250812T185437Z
LAST-MODIFIED:20250812T185558Z
UID:16584-1758555000-1758560400@www.centreforbrainhealth.ca
SUMMARY:Crafting Visual Explanations of Complex Science: Philosophy and Practice
DESCRIPTION:This month\, Martin Krzywinski\, Canada’s Michael Smith Genome Sciences Centre will present “Crafting Visual Explanations of Complex Science: Philosophy and Practice.” \nYou’ll learn practical guidelines for crafting visual explanations of your science: form follows function\, treat everything as data\, seek crispness\, fight the shackles of convention\, and ask yourself “Is this good for the reader or for me?”. To illustrate these ideas concretely\, Martin will take you through the process of redesigning figures\, posters and graphical abstracts — submitted by you or from past case studies. \nSubmit your work to see this process applied to graphics that are directly relevant to you: https://bit.ly/matrix-n \nSee event poster for more details \n  \nZoom link if unable to attend in person:\nhttps://ubc.zoom.us/j/5936706150?pwd=bWFoeDNGMkk2ZVNOQk9FTFZIT0lZdz09&omn=62102214283 \n 
URL:https://www.centreforbrainhealth.ca/events/crafting-visual-explanations-of-complex-science-philosophy-and-practice/
LOCATION:DMCBH Room 3402\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Monthly Monday Rounds in Mental Health and Addictions
ATTACH;FMTTYPE=image/jpeg:https://www.centreforbrainhealth.ca/wp-content/uploads/2025/08/Mental-Health-IRP-rounds-Sept-2025.jpeg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20250926T110000
DTEND;TZID=America/Vancouver:20250926T120000
DTSTAMP:20260315T084747
CREATED:20250417T180736Z
LAST-MODIFIED:20250818T171918Z
UID:15836-1758884400-1758888000@www.centreforbrainhealth.ca
SUMMARY:Dr. Andrienne Antonson: Blueprint for the Developing Brain: Cues from Microbes\, Myeloid Cells\, and the Maternal-Fetal Interface
DESCRIPTION:Emerging evidence suggests that key neurodevelopmental processes are shaped by immune and microbial signals during the prenatal period. My work is based on the premise that disruptions to these signals can alter neurodevelopmental trajectories and increase vulnerability to lifelong mental health disorders. Using a clinically translatable mouse model of maternal influenza infection\, we demonstrate that prenatal inflammatory insults compromise vascular integrity in both the placenta and fetal brain\, allowing bloodborne molecules to cross transplacental and blood-brain barriers. These changes are associated with cortical thinning\, altered fetal microglia and meningeal macrophage signaling\, and shifts in circulating maternal and fetal microbial metabolites. Together\, these findings highlight converging pathways through which maternal inflammation may influence fetal brain development and long-term psychiatric risk.
URL:https://www.centreforbrainhealth.ca/events/dr-andrienne-antonson/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20251003T110000
DTEND;TZID=America/Vancouver:20251003T120000
DTSTAMP:20260315T084747
CREATED:20250417T181420Z
LAST-MODIFIED:20250819T195406Z
UID:15841-1759489200-1759492800@www.centreforbrainhealth.ca
SUMMARY:Dr. Erik Bloss: Synapse plasticity in learning and disease states
DESCRIPTION:Synapses are the computational subunits of the brain. They allow cell-type specific forms of information flow\, permit neurons to compartmentalize electrical and biochemical signals\, and undergo rapid structural plasticity during experience. Although Crick suggested spine plasticity was a correlate of memory more than 40 years ago\, it has been hard to understand precisely how the plasticity of spines drives cognitive function. We have examined this issue in two contexts: one in which mice are required to learn competing memory traces\, and one in which mice are engineered to express mutant amyloid as a model of Alzheimer’s disease (AD). I will present unpublished data that suggest adaptive learning requires spine plasticity in specific cortical neurons\, at specific synaptic sites\, and in a sex-specific manner. In AD mice\, the loss of synapses appears to coincide with interference between memory traces. These results suggest new ways in which plasticity might support memory functions.
URL:https://www.centreforbrainhealth.ca/events/dr-erik-bloss/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
END:VEVENT
END:VCALENDAR