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X-WR-CALNAME:Djavad Mowafaghian Centre for Brain Health | DMCBH
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X-WR-CALDESC:Events for Djavad Mowafaghian Centre for Brain Health | DMCBH
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BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20231020T110000
DTEND;TZID=America/Vancouver:20231020T120000
DTSTAMP:20260418T145741
CREATED:20220604T014558Z
LAST-MODIFIED:20230822T172646Z
UID:9072-1697799600-1697803200@www.centreforbrainhealth.ca
SUMMARY:Dr. Randy McIntosh: Hidden Repertoires in Cognitive Function and Dysfunction
DESCRIPTION:Zoom option if unable to attend in person:\nZoom link here (click on “Join a meeting”)\nMeeting ID: 91512 289258\nPasscode: 289258\n\nA hidden repertoire is a functional configuration in the brain that supports behaviour but is seldom used. As a complex system\, the brain can show a broad range of configurations for the same function. This “many-to-one” property imparts our brain with resilience during normal operations but also in the face of adverse events\, such as damage or disease. I will cover the evidence for these repertoires and cover strategies for investigation\, and the implication for the I will also relate the existence of such repertoires to variations in the qualia of our experience.
URL:https://www.centreforbrainhealth.ca/events/dr-randy-mcintosh/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20231103T110000
DTEND;TZID=America/Vancouver:20231103T120000
DTSTAMP:20260418T145741
CREATED:20230424T173144Z
LAST-MODIFIED:20231016T194129Z
UID:10765-1699009200-1699012800@www.centreforbrainhealth.ca
SUMMARY:Dr. Douglas Wylie: Cerebellar Control of Flight in Birds: Easy as 1\, 2\, 3
DESCRIPTION:Zoom option if unable to attend in person:\nZoom link here (click on “Join a meeting”)\nMeeting ID: 91512 289258\nPasscode: 289258\n\nThe cerebellum contains the majority of neurons in the brain and has been implicated with many aspects of motor control. In birds this includes the control of flight. In this talk\, by synthesizing behavioral\, neurophysiological\, neuroanatomical and paleontological data I will emphasize three points: (i) the expansion of the cerebellum in birds is associated with the evolution of powered flight; (ii) retinal-recipient nuclei that analyze optic flow are critical for controlling flight; and (iii) three different visuomotor areas of the cerebellum are involved in controlling different aspects of flight.
URL:https://www.centreforbrainhealth.ca/events/dr-douglas-wylie/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20231117T110000
DTEND;TZID=America/Vancouver:20231117T120000
DTSTAMP:20260418T145741
CREATED:20230329T173920Z
LAST-MODIFIED:20230829T165650Z
UID:10612-1700218800-1700222400@www.centreforbrainhealth.ca
SUMMARY:Dr. Rosemary Bagot:  At the intersection of threat and reward in nucleus accumbens glutamatergic afferents.
DESCRIPTION:Zoom option if unable to attend in person:\nZoom link here (click on “Join a meeting”)\nMeeting ID: 91512 289258\nPasscode: 289258\n\nThe nucleus accumbens integrates diverse inputs\, balancing threat and reward to orchestrate motivated behaviour. Glutamatergic projections from the ventral hippocampus and medial prefrontal cortex converge in the accumbens medial shell and are implicated in reward processing as well as adaptation to chronic stress. How these pathways integrate aversive or appetitive events to modulate behaviour is not fully understood and largely unstudied in females\, despite known sex-differences in stress-related psychopathologies. I will present new data using pathway-specific in vivo fibre-photometry and chemogenetic silencing to uncover how these projections encode aversive experiences to shape behavioural responding to threat and integrate information about the outcome of actions to shape learning about reward.
URL:https://www.centreforbrainhealth.ca/events/dr-rosemary-bagot/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20231124T110000
DTEND;TZID=America/Vancouver:20231124T120000
DTSTAMP:20260418T145741
CREATED:20230329T174100Z
LAST-MODIFIED:20231003T185618Z
UID:10614-1700823600-1700827200@www.centreforbrainhealth.ca
SUMMARY:Dr. Irene Vavasour: Diving into neuroimaging research with FINS
DESCRIPTION:Zoom option if unable to attend in person:\nZoom link here (click on “Join a meeting”)\nMeeting ID: 91512 289258\nPasscode: 289258\n\nThe Fipke Integrated Neuroimaging Suite (FINS) hosts state-of-the-art neuroimaging equipment including a 3T Philips MRI scanner and a 3T GE PET/MR scanner. Our translational research includes developing better imaging tools for disorders such as multiple sclerosis\, Parkinson’s\, Alzheimer’s\, stroke\, traumatic brain injury and mental health\, as well as healthy aging. This presentation will discuss many of our novel imaging techniques\, including myelin water imaging\, how and why they are used and what up and coming developments are available.
URL:https://www.centreforbrainhealth.ca/events/dr-irene-vavasour/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20231201T110000
DTEND;TZID=America/Vancouver:20231201T120000
DTSTAMP:20260418T145741
CREATED:20230404T192402Z
LAST-MODIFIED:20231022T181816Z
UID:10675-1701428400-1701432000@www.centreforbrainhealth.ca
SUMMARY:Dr. Mark Bevan: Dysregulation and rescue of subthalamic nucleus locomotor function in Huntington’s disease mice
DESCRIPTION:Zoom option if unable to attend in person:\nZoom link here (click on “Join a meeting”)\nMeeting ID: 91512 289258\nPasscode: 289258\n\nIn this seminar I will focus on our recent studies on the role of the subthalamic nucleus in motor control and its dysregulation in movement disorders.  We found that 1) subthalamic locomotor encoding and gait are highly dysregulated in Q175 Huntington’s disease (HD) mice 2) analogous gait deficits could be generated in wild type mice through optogenetic manipulation of subthalamic activity 3) subthalamic locomotor encoding and gait could be rescued in HD mice through suppression of subthalamic mutant huntingtin expression. Together\, these findings argue that subthalamic activity normally optimizes movement\, whereas dysregulated subthalamic activity contributes to gait deficits in HD and is a potential target for therapeutic intervention.
URL:https://www.centreforbrainhealth.ca/events/dr-mark-bevan/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20231208T110000
DTEND;TZID=America/Vancouver:20231208T120000
DTSTAMP:20260418T145741
CREATED:20230511T164358Z
LAST-MODIFIED:20231124T105827Z
UID:10880-1702033200-1702036800@www.centreforbrainhealth.ca
SUMMARY:Dr. Adrienne Fairhall: Cognitive rule-switching in macaques.
DESCRIPTION:Zoom option if unable to attend in person:\nZoom link here (click on “Join a meeting”)\nMeeting ID: 91512 289258\nPasscode: 289258\n\nWhat is the neural basis of abstraction? Working in collaboration with experimental groups who have trained monkeys and humans on a decision task\, we analyze how subjects make use of visual information and feedback to infer a hidden rule\, where the rule switches in an uncued fashion. We fit a suite of behavioral models and learn that while humans are close to optimal Bayesian agents\, monkey behavior is better fit as reinforcement learning\, with a novel additional factor included. We use this behavioral model to elucidate structure in neural activity recorded from 200 sites across the brain\, finding low-dimensional and dynamic representations of stimulus\, feedback and  reward prediction error that support the notion of internal states captured by the behavioral model. \n 
URL:https://www.centreforbrainhealth.ca/events/dr-adrienne-fairhall/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20240112T110000
DTEND;TZID=America/Vancouver:20240112T120000
DTSTAMP:20260418T145741
CREATED:20230404T193658Z
LAST-MODIFIED:20231215T191849Z
UID:10681-1705057200-1705060800@www.centreforbrainhealth.ca
SUMMARY:Dr. Joshua Berke: Time\, Space and Dopamine
DESCRIPTION:Zoom option if unable to attend in person:\nZoom link here (click on “Join a meeting”)\nMeeting ID: 91512 289258\nPasscode: 289258\n\nDopamine is famously involved in reward\, but exactly how continues to be the subject of debate. Two key functions include signaling reward expectations to promote motivated\, effortful work\, and signaling errors in reward expectation to promote learning. I will present new studies from my laboratory examining each of these processes. We combine recent technological advances for measuring dopamine with novel behavioral tasks\, to probe how animals compute reward expectations over multiple temporal and spatial scales. \n 
URL:https://www.centreforbrainhealth.ca/events/dr-joshua-berke/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20240126T110000
DTEND;TZID=America/Vancouver:20240126T120000
DTSTAMP:20260418T145741
CREATED:20230508T171528Z
LAST-MODIFIED:20240124T030752Z
UID:10833-1706266800-1706270400@www.centreforbrainhealth.ca
SUMMARY:UBC Kickstart Updates: Dr. Anthony Phillips and Dr. Kamyar Keramatian
DESCRIPTION:Zoom option if unable to attend in person:\nZoom link here (click on “Join a meeting”)\nMeeting ID: 91512 289258\nPasscode: 289258
URL:https://www.centreforbrainhealth.ca/events/ubc-kickstart-updates-phillips-keramatian/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20240202T110000
DTEND;TZID=America/Vancouver:20240202T120000
DTSTAMP:20260418T145741
CREATED:20230508T171612Z
LAST-MODIFIED:20240124T030933Z
UID:10835-1706871600-1706875200@www.centreforbrainhealth.ca
SUMMARY:UBC Kickstart Updates: Drs. Ipek Oruc\, Daniela Palombo and Catharine Winstanley
DESCRIPTION:Zoom option if unable to attend in person:\nZoom link here (click on “Join a meeting”)\nMeeting ID: 91512 289258\nPasscode: 289258
URL:https://www.centreforbrainhealth.ca/events/ubc-kickstart-updates-oruc-palombo-winstanley/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20240209T110000
DTEND;TZID=America/Vancouver:20240209T120000
DTSTAMP:20260418T145741
CREATED:20230511T164554Z
LAST-MODIFIED:20240108T194518Z
UID:10882-1707476400-1707480000@www.centreforbrainhealth.ca
SUMMARY:Dr. Harriet de Wit: Microdosing:  Fact or Fiction?
DESCRIPTION:Zoom option if unable to attend in person:\nZoom link here (click on “Join a meeting”)\nMeeting ID: 91512 289258\nPasscode: 289258\n\nDr. Harriet de Wit will review evidence for the purported beneficial effects of ‘microdosing’ psychedelic drugs\, specifically LSD.  She will describe recent studies from her laboratory investigating behavioral and neural effects of low doses of LSD in healthy adults.  She will illustrate some of the methodological challenges researchers face in investigating the effects of very low doses of drugs.
URL:https://www.centreforbrainhealth.ca/events/dr-harriet-de-wit/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20240216T110000
DTEND;TZID=America/Vancouver:20240216T120000
DTSTAMP:20260418T145741
CREATED:20220728T171519Z
LAST-MODIFIED:20240123T165128Z
UID:9405-1708081200-1708084800@www.centreforbrainhealth.ca
SUMMARY:Dr. Emily Liman: The secret of sour: Discovery structure and function of the sour receptor OTOP1.
DESCRIPTION:Zoom option if unable to attend in person:\nZoom link here (click on “Join a meeting”)\nMeeting ID: 91512 289258\nPasscode: 289258\n\nIdentifying and discriminating among compounds prior to ingestion is essential for animals to survive and thrive. Taste receptor cells encode five basic taste qualities\, for which receptors and signaling pathways had been described for all but sour taste.  Here I will describe the identification from a screen of genes enriched in sour taste cells of the sour receptor\, OTOP1. OTOP1 forms a proton channel\, structurally unrelated to previously described ion channels. OTOP1 assembles as a dimer\, with three putative pathways\, gated by protons and Zn2+. Our recent findings expand the role of OTOP1 in taste cells to the detection of ammonium chloride\, a potent taste stimulus used in salty licorice. OTOP1 is a member of a small family of ion channels found throughout the body and conserved across evolution. Ongoing work is aimed at discovering the roles of OTOP channels to various physiological and pathophysiological processes.
URL:https://www.centreforbrainhealth.ca/events/dr-emily-liman/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20240223T110000
DTEND;TZID=America/Vancouver:20240223T120000
DTSTAMP:20260418T145741
CREATED:20230331T172027Z
LAST-MODIFIED:20240116T204216Z
UID:10646-1708686000-1708689600@www.centreforbrainhealth.ca
SUMMARY:Dr. Ramon Diaz-Arrastia: Traumatic brain injury-related neurodegeneration:  What is the pathology.
DESCRIPTION:Zoom option if unable to attend in person:\nZoom link here (click on “Join a meeting”)\nMeeting ID: 91512 289258\nPasscode: 289258\n\nEvidence accumulated over the past decades has shown that for many patients\, traumatic brain injury (TBI) triggers cellular and molecular processes that continue to evolve long after the acute period and initial recovery. While these mechanisms result in short-term tissue repair and regeneration\, the reparative process is often incomplete\, and can also be maladaptive. Long-term outcomes after TBI are not fixed\, but rather there can be improvement or deterioration years\, even decades\, after injury. TBI can result in long-term impairment and disability and increases risk of remote neurodegeneration and dementia.  It is estimated that 5-10% of the population-wide burden of dementia is associated with TBI. \nDespite the substantial societal burden imposed by long-term neurodegeneration and dementia after TBI\, little is known about the underlying pathophysiological mechanisms of trauma-related neurodegeneration (TReND). For decades it was believed that TBI was associated with an increased risk for Alzheimer’s disease\, but recent work indicates that other pathologies\, including microvasculopathy\, axonal degeneration\, and neuroinflammation play prominent roles. \nThis presentation will review the epidemiologic data regarding TReND and will then discuss insights from neuropathologic studies on long-term survivors after TBI.  Recent work using neuroimaging and molecular biomarkers measured years after TBI will be reviewed.  Finally\, we will discuss recent work pointing to potential therapeutic interventions.
URL:https://www.centreforbrainhealth.ca/events/dr-ramon-diaz-arrastia/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20240301T110000
DTEND;TZID=America/Vancouver:20240301T120000
DTSTAMP:20260418T145741
CREATED:20230331T172220Z
LAST-MODIFIED:20231215T192022Z
UID:10648-1709290800-1709294400@www.centreforbrainhealth.ca
SUMMARY:Dr. Janine Kwapis: Time to learn: Diurnal regulation of memory by the clock gene Per1
DESCRIPTION:Zoom option if unable to attend in person:\nZoom link here (click on “Join a meeting”)\nMeeting ID: 91512 289258\nPasscode: 289258\n\nMany biological processes\, including memory formation\, are strongly influenced by the circadian system\, which synchronizes animals’ internal states with the external time of day. Long-term memory performance changes across the day/night cycle in both humans and rodents\, yet the mechanisms that support this process are largely unknown. In this talk\, I will present my lab’s research suggesting that a circadian clock gene\, Period1 (Per1) may serve as a molecular interface between the circadian clock and memory formation. Per1 oscillates in tandem with memory in memory-relevant brain regions\, like the hippocampus\, with both memory and Per1 levels peaking during the day and showing a trough at night. Interestingly\, old animals have repressed hippocampal Per1 levels even during the day\, suggesting that they may show impairments in memory due to this persistent “nighttime state” that limits memory across the diurnal cycle. Together\, our data suggest that Per1 may function locally in memory-relevant brain regions to exert diurnal control over memory.
URL:https://www.centreforbrainhealth.ca/events/dr-janine-kwapis/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20240308T110000
DTEND;TZID=America/Vancouver:20240308T120000
DTSTAMP:20260418T145741
CREATED:20230411T202133Z
LAST-MODIFIED:20240405T181817Z
UID:10713-1709895600-1709899200@www.centreforbrainhealth.ca
SUMMARY:Dr. Nick Steinmetz: Brain-wide coordinated dynamics and Neuropixels Ultra
DESCRIPTION:Zoom option if unable to attend in person:\nZoom link here (click on “Join a meeting”)\nMeeting ID: 91512 289258\nPasscode: 289258\n\nIn this talk\, I will describe two recent projects in my lab. In the first\, we discovered that brain-wide spatiotemporal dynamics (i.e. traveling waves) are coordinated on a moment-to-moment basis between neocortex and striatum\, thalamus\, and midbrain. We used widefield calcium imaging and Neuropixels 2.0 recordings in combination to reveal the structure of these waves in the mouse brain\, including a link to the underlying axonal architecture that supports them. Second\, I will talk about our work developing a new version of the Neuropixels probe\, called ‘Neuropixels Ultra’\, which has much smaller and denser recording sites than previous versions. This configuration yields improved characteristics for some applications and reveals new observations about the biophysical phenomena observable with extracellular electrophysiology.
URL:https://www.centreforbrainhealth.ca/events/dr-nick-steinmetz/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20240315T110000
DTEND;TZID=America/Vancouver:20240315T120000
DTSTAMP:20260418T145741
CREATED:20230424T175212Z
LAST-MODIFIED:20240131T182813Z
UID:10771-1710500400-1710504000@www.centreforbrainhealth.ca
SUMMARY:Dr. David Holtzman: The role of APOE and the immune response in amyloid-induced tauopathy and tau-mediated neurodegeneration
DESCRIPTION:Zoom option if unable to attend in person:\nZoom link here (click on “Join a meeting”)\nMeeting ID: 91512 289258\nPasscode: 289258
URL:https://www.centreforbrainhealth.ca/events/dr-david-holtzman/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20240322T110000
DTEND;TZID=America/Vancouver:20240322T120000
DTSTAMP:20260418T145741
CREATED:20230406T170904Z
LAST-MODIFIED:20240206T184413Z
UID:10701-1711105200-1711108800@www.centreforbrainhealth.ca
SUMMARY:Dr. Alicia Izquierdo: Translational models of frontocortical circuits in learning and decision making
DESCRIPTION:Zoom option if unable to attend in person:\nZoom link here (click on “Join a meeting”)\nMeeting ID: 91512 289258\nPasscode: 289258\n\nOrbitofrontal cortex (OFC) and Anterior cingulate cortex (ACC) have been assigned various overlapping roles ranging from learning and responding to reward\, signaling value and uncertainty\, and supporting economic decisions\, to name a few. Both of these regions share reciprocal anatomical connections with basolateral amygdala\, contributing to functional similarities among these circuits. Using a combination of novel behavioral paradigms\, DREADDs\, and 1P calcium imaging in freely-moving rats\, our lab has sought better resolution of diverse frontocortical processes. In this talk I will present data comparing subregional frontal cortex contributions\, together with basolateral amygdala\, in reward learning and value-based decisions. With few exceptions\, our results suggest mostly overlapping\, less specialized\, roles for ACC and OFC that point to complementary roles in keeping track of expected uncertainty\, or the range of typically-experienced outcomes. Collectively these findings may have implications for how we view frontocortical contributions across rodent and primate species.
URL:https://www.centreforbrainhealth.ca/events/dr-alicia-izquierdo/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20240405T110000
DTEND;TZID=America/Vancouver:20240405T120000
DTSTAMP:20260418T145741
CREATED:20230417T173340Z
LAST-MODIFIED:20240307T191322Z
UID:10735-1712314800-1712318400@www.centreforbrainhealth.ca
SUMMARY:Dr. Kaarina Kowalec: Depression polygenicity and its association with multiple sclerosis disease activity and progression.
DESCRIPTION:Zoom option if unable to attend in person:\nZoom link here (click on “Join a meeting”)\nMeeting ID: 91512 289258\nPasscode: 289258\n\nDepression is a common comorbidity in those with multiple sclerosis (MS) and is associated with faster MS disability progression. Identifying who may be at higher risk for depression or faster disease activity or progression may facilitate earlier identification. We will examine the polygenicity of comorbid depression in MS and whether it is associated with MS disease activity & disability progression in multiple cohorts from Canada\, the USA\, Sweden\, and UK Biobank.
URL:https://www.centreforbrainhealth.ca/events/dr-kaarina-kowalec/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20240412T110000
DTEND;TZID=America/Vancouver:20240412T120000
DTSTAMP:20260418T145741
CREATED:20230511T164744Z
LAST-MODIFIED:20240212T195620Z
UID:10884-1712919600-1712923200@www.centreforbrainhealth.ca
SUMMARY:Dr. Carrie Ferrario: Alterations in brain & behavior that contribute to obesity
DESCRIPTION:Zoom option if unable to attend in person:\nZoom link here (click on “Join a meeting”)\nMeeting ID: 91512 289258\nPasscode: 289258\n\nWhile urges to eat are regulated by hunger\, satiety\, and energy demand\, they are also strongly influenced by sights\, sounds\, and smells that are associated with food (food cues). These food cues can influence feeding behavior\, triggering cravings that can promote overeating. Dr. Ferrario’s lab examines the neurobiological mechanisms of cue-triggered food craving\, and how these processes are influenced by susceptibility to diet-induced obesity and by consumption of sugary\, fatty\, “junk-food” diets. In her talk\, she will discuss how enhanced responsivity to food cues contributes to obesity\, and how eating “junk-foods” enhances excitatory transmission within the NAc to influence food “craving”. She will also highlight sex differences in these effects\, and the role that susceptibility to obesity plays in diet-induced plasticity.
URL:https://www.centreforbrainhealth.ca/events/dr-carrie-ferrario/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20240419T110000
DTEND;TZID=America/Vancouver:20240419T120000
DTSTAMP:20260418T145741
CREATED:20230331T172411Z
LAST-MODIFIED:20240314T173118Z
UID:10650-1713524400-1713528000@www.centreforbrainhealth.ca
SUMMARY:Dr. Aki Taruno: A chemical synapse that lacks vesicles
DESCRIPTION:Zoom option if unable to attend in person:\nZoom link here (click on “Join a meeting”)\nMeeting ID: 91512 289258\nPasscode: 289258\n\nChemical neurotransmission is essential for a variety of neural processes and is traditionally understood to be mediated by Ca2+-dependent exocytosis of synaptic vesicles. Nevertheless\, it has been recognized for decades that taste receptor cells in taste buds do not possess synaptic vesicles\, yet they can transmit gustatory information to the nervous system. Here I will describe the identification of a unique synapse of taste receptor cells where the ion-conducting pore of a voltage-gated channel\, CALHM1/3\, serves as the conduit for action potential-dependent neurotransmitter (ATP) release. This mechanism has been termed a ‘channel synapse.’ Anatomically\, a channel synapse is characterized by its tripartite structure\, which includes a presynaptic mitochondrion adjacent to a CALHM1/3-enriched plasma membrane that faces a post-synaptic afferent nerve. Our recent discoveries extend the roles of channel synapses to various extraoral physiological and pathophysiological processes.
URL:https://www.centreforbrainhealth.ca/events/dr-aki-taruno/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20240503T110000
DTEND;TZID=America/Vancouver:20240503T120000
DTSTAMP:20260418T145741
CREATED:20230509T191925Z
LAST-MODIFIED:20240213T214218Z
UID:10857-1714734000-1714737600@www.centreforbrainhealth.ca
SUMMARY:Dr. Edward Boyden: Tools for Analyzing and Repairing the Brain
DESCRIPTION:Zoom option if unable to attend in person:\nZoom link here (click on “Join a meeting”)\nMeeting ID: 91512 289258\nPasscode: 289258\n\nUnderstanding and repairing complex biological systems\, such as the brain\, requires technologies for systematically observing and controlling these systems.  We are discovering new molecular principles that enable such technologies.  For example\, we discovered that one can physically magnify biological specimens by synthesizing dense networks of swellable polymer throughout them\, and then chemically processing the specimens to isotropically swell them.  This method\, which we call expansion microscopy\, enables ordinary microscopes to do nanoimaging – important for mapping molecules throughout cells\, and cells throughout brain circuits.  Expansion of biomolecules away from each other also decrowds them\, enabling previously invisible nanostructures to be labeled\, and seen.  As a second example\, we discovered that microbial opsins\, genetically expressed in neurons\, could enable their electrical activities to be precisely controlled in response to light.  These molecules\, called optogenetic tools\, enable causal assessment of how neurons contribute to behaviors and pathological states\, and are yielding insights into new treatment strategies for brain diseases.  They are also beginning to be used in human patients\, in experimental clinical contexts like treating blindness. Finally\, we are developing\, using new strategies such as robotic directed evolution\, fluorescent reporters that enable the precision measurement of signals such as voltage.  In order to reveal relationships between different molecular signals within a cell\, we are developing spatial and temporal multiplexing strategies that enable many such signals to be imaged at once in the same living cell\, using ordinary microscopes\, and requiring only fully genetically encoded constructs.  We share all these tools freely\, and aim to integrate the use of these tools so as to enable comprehensive understandings of neural circuits.
URL:https://www.centreforbrainhealth.ca/events/dr-edward-boyden/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20240510T110000
DTEND;TZID=America/Vancouver:20240510T120000
DTSTAMP:20260418T145741
CREATED:20230329T202358Z
LAST-MODIFIED:20240314T172754Z
UID:10626-1715338800-1715342400@www.centreforbrainhealth.ca
SUMMARY:Dr. Anne West: From chromatin regulation to synapse development in neurodevelopmental disorders
DESCRIPTION:Zoom option if unable to attend in person:\nZoom link here (click on “Join a meeting”)\nMeeting ID: 91512 289258\nPasscode: 289258\n\nChromatin regulatory proteins are a major class of gene products for which sequence variants are associated with autism spectrum disorders and intellectual disability; however\, the functional consequences of these mutations for brain development remain poorly understood. We are identifying molecular mechanisms through which chromatin regulatory enzymes promote the expression of synaptic gene products and functional neuronal maturation. I will discuss how our studies are working to build a foundation for understanding how dysregulation of chromatin regulation in the developing brain leads to neurodevelopmental disorders.
URL:https://www.centreforbrainhealth.ca/events/dr-anne-west/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20240524T110000
DTEND;TZID=America/Vancouver:20240524T120000
DTSTAMP:20260418T145741
CREATED:20230406T165944Z
LAST-MODIFIED:20240506T180656Z
UID:10695-1716548400-1716552000@www.centreforbrainhealth.ca
SUMMARY:Dr. Brian Corneil: Responding when time is of the essence: a subcortical substrate for rapid visually-guided reaching.
DESCRIPTION:Zoom option if unable to attend in person:\nZoom link here (click on “Join a meeting”)\nMeeting ID: 91512 289258\nPasscode: 289258\n\nHumans operate in a dynamic and uncertain world; sudden changes in an object’s position require rapid changes in motor control. Previous research in humans has shown that on-going visually-guided actions can be altered at latencies that approach minimal afferent and efferent conduction delays. The contribution of such a fast visuomotor system to overall motor control has long been recognized\, but fundamental questions remain about the underlying neural substrates\, and about the comparative contribution of cortical versus subcortical pathways. \nMy talk will focus on converging work on express responses in humans and non-human primates (NHPs). One type of express response is the express saccade\, and another type is what we term an “express visuomotor response”\, which can appear on upper-limb muscles in humans in less than 100 ms\, and in less than 65 ms in animal models. Such remarkably short latencies limit the opportunity for extensive cortical processing\, leading to the hypothesis that express visuomotor responses arise via tecto-reticulo-spinal signalling through the superior colliculus. Ongoing experiments establish that visually-related reaching signals arise within ~50 ms in the movement related layers of the superior colliculus\, which appears early enough to generate express visuomotor responses. These results set the stage for comparative analysis of signal timing in frontal cortical areas. In the final part of my talk\, I will discuss recent findings which show that express visuomotor responses persist in Parkinson’s Disease\, despite degradation of signals related to deliberative reaching. Across all studies\, we are seeing compelling similarities between the properties of express responses and the visual transient in the superior colliculus (SC). Such findings lead us to suggest that a subcortical tecto-reticulo-spinal circuit\, which itself can be primed by cortical inputs\, distributes the earliest visuomotor response that is shared across multiple body effectors.
URL:https://www.centreforbrainhealth.ca/events/dr-brian-corneil/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20240531T110000
DTEND;TZID=America/Vancouver:20240531T120000
DTSTAMP:20260418T145741
CREATED:20230328T203831Z
LAST-MODIFIED:20240528T221046Z
UID:10601-1717153200-1717156800@www.centreforbrainhealth.ca
SUMMARY:Dr. Khaled Abdelrahman: Decoding the Intricacies of GPCR Signaling in neurodegenerative diseases
DESCRIPTION:Our research focuses on the intricate role of specific G protein-coupled receptors (GPCRs) in the pathophysiology of neurodegenerative diseases. A key aspect of our focus is unraveling the sex-specific regulation of GPCR signaling in these conditions. Through exploring these intricacies\, we aim to illuminate novel therapeutic avenues and enhance our understanding of the complex interplay between GPCRs and neurodegeneration. \nZoom link: https://ubc.zoom.us/j/67841144478?pwd=K0M9aLiUz8wxKl14bF4giFskCDjMWY.1 \nMeeting ID: 678 4114 4478\nPasscode: 0000
URL:https://www.centreforbrainhealth.ca/events/dr-khaled-abdelrahman/
LOCATION:DMCBH Room 3402\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20240920T110000
DTEND;TZID=America/Vancouver:20240920T120000
DTSTAMP:20260418T145741
CREATED:20240321T172611Z
LAST-MODIFIED:20240726T182156Z
UID:13091-1726830000-1726833600@www.centreforbrainhealth.ca
SUMMARY:Dr. Peri Kurshan: Protein-lipid interactions drive presynaptic assembly prior to cell-adhesion molecule recruitment
DESCRIPTION:Zoom option if unable to attend in person:\nZoom link here (click on “Join a meeting”)\nMeeting ID: 91512 289258\nPasscode: 289258\n\nOur lab uses C. elegans to study the molecular mechanisms of synapse development\, focusing on how presynaptic proteins such as neurexins and active zone scaffold molecules interact and assemble. We have found a surprising role for protein-lipid interactions early in the process of synapse assembly. We also use C. elegans to model human patient mutations in presynaptic calcium channels to gain a better understanding of how and why these mutations lead to varied patient manifestations.
URL:https://www.centreforbrainhealth.ca/events/dr-peri-kurshan/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20240927T110000
DTEND;TZID=America/Vancouver:20240927T120000
DTSTAMP:20260418T145741
CREATED:20230601T215004Z
LAST-MODIFIED:20240815T212836Z
UID:11104-1727434800-1727438400@www.centreforbrainhealth.ca
SUMMARY:Dr. Katharine Smith: Illuminating mechanisms of inhibitory synapse function and plasticity
DESCRIPTION:Zoom option if unable to attend in person:\nZoom link here (click on “Join a meeting”)\nMeeting ID: 91512 289258\nPasscode: 289258\n\nThe Smith lab investigates the molecular mechanisms that underly synaptic inhibition\, its plasticity and how it is disrupted in disease. We use advanced microscopy techniques like super-resolution microscopy to analyze the fine details of the synapse\, and link these findings to synapse function and diversity\, therefore providing a new logic to synaptic inhibition.
URL:https://www.centreforbrainhealth.ca/events/dr-katharine-smith/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20241018T110000
DTEND;TZID=America/Vancouver:20241018T120000
DTSTAMP:20260418T145741
CREATED:20240320T163934Z
LAST-MODIFIED:20240729T204157Z
UID:13069-1729249200-1729252800@www.centreforbrainhealth.ca
SUMMARY:Dr. Carrie Esopenko: Intimate Partner Violence-Brain Injury: What We Know and How Can We help?
DESCRIPTION:Zoom option if unable to attend in person:\nZoom link here (click on “Join a meeting”)\nMeeting ID: 91512 289258\nPasscode: 289258\n\nDr. Carrie Esopenko is an Associate Professor in the Brain Injury Research Center at the Icahn School of Medicine at Mount Sinai Hospital in New York City. She is also holds an adjunct faculty appointment at the Traumatic Brain Injury and Concussion Center at the University of Utah\, as well as in the Department of Family Medicine and Community Health at Rutgers – Robert Wood Johnson Medical School. She is the principal investigator of a National Institute of Neurological Disorders and Stroke R01-funded multi-site study examining the psychological\, cognitive\, and neural signatures of IPV-related head trauma. She is the Lead Investigator of the ENIGMA Intimate Partner Violence (IPV) Working Group seeking to increase IPV brain injury research collaborations worldwide\, and co-leads ENIGMA Global Knowledge Exchange Network which seeks to provide education and training supports to service providers and advocates working with IPV-related brain injury. Her research focuses on understanding the effects of neurotrauma and mental health conditions across populations\, and identifying methods for injury prevention and patient-specific and community-based intervention strategies. \n 
URL:https://www.centreforbrainhealth.ca/events/dr-carrie-esopenko/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20241025T110000
DTEND;TZID=America/Vancouver:20241025T120000
DTSTAMP:20260418T145741
CREATED:20230707T175926Z
LAST-MODIFIED:20240723T191932Z
UID:11308-1729854000-1729857600@www.centreforbrainhealth.ca
SUMMARY:Dr. Catherine Peña:  Early life stress primes sensitivity to future stress: from engrams to epigenetics
DESCRIPTION:Zoom option if unable to attend in person:\nZoom link here (click on “Join a meeting”)\nMeeting ID: 91512 289258\nPasscode: 289258\n\nEarly life stress increases sensitivity to stress later in life\, which may be at the root of increased risk for mental health disorders. Our work seeks to understand the mechanistic underpinnings of this heightened stress sensitivity. Using transgenic mice to label and capture experience-actiated neurons\, we show that neurons active during early life stress are more likely to be reactivated during adult stress experience\, and that chemogenetically inhibiting these neurons rescues behavioral changes. Heightened cellular reactivity may be due to long-lasting changes in the epigenome that leave chromatin more open and transcriptionally reactive to additional stimuli\, particularly in stress-activated neurons. Together\, this work supports a biological model in which stress alters chromatin development\, leading to increased cellular reactivity and ultimately behavioral sensitivity to future stress.
URL:https://www.centreforbrainhealth.ca/events/dr-catherine-pena/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20241101T110000
DTEND;TZID=America/Vancouver:20241101T120000
DTSTAMP:20260418T145741
CREATED:20240320T233835Z
LAST-MODIFIED:20240806T181502Z
UID:13085-1730458800-1730462400@www.centreforbrainhealth.ca
SUMMARY:Dr. Edmund Au: Elucidating Principles of Cortical Interneuron Synaptic Organization
DESCRIPTION:Zoom option if unable to attend in person:\nZoom link here (click on “Join a meeting”)\nMeeting ID: 91512 289258\nPasscode: 289258\n\nCortical interneurons are the most transcriptionally and morphologically diverse neurons in the brain\, characterized in part by their striking degree of synaptic specificity. However\, little is known about the extent of their synaptic diversity due to the lack of unbiased methods to extract features of synaptic organization among interneuron subtypes. In this talk\, I will introduce an approach we developed that combines imaging and computational extraction of synaptic features from genetically-identified interneuron synapses and their subcellular specificity among postsynaptic targets. A machine-learning approach (1) reveals hundreds of spatial and structural features from each analyzed synapse\, (2) constructs a multidimensional data set\, consisting of millions of synapses\, and (3) uncovers novel synaptic subgroups. By analyzing this dataset\, we found that dendrite-targeting synaptic subgroups were clustered onto distinct subdomains of the dendrite along the proximal to distal axis; Soma-targeting subgroups were enriched onto different postsynaptic cell types; Finally\, the two main subclasses of interneurons\, basket cells and somatostatin interneurons\, utilize distinct strategies to enact inhibitory synaptic coverage. Thus\, we uncover previously unknown structural and topological features of inhibitory synaptic organization and establishes a conceptual framework for studying inhibitory synaptic diversity in health and disease.
URL:https://www.centreforbrainhealth.ca/events/dr-edmund-au/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20241115T110000
DTEND;TZID=America/Vancouver:20241115T120000
DTSTAMP:20260418T145741
CREATED:20240321T193757Z
LAST-MODIFIED:20240808T173346Z
UID:13094-1731668400-1731672000@www.centreforbrainhealth.ca
SUMMARY:Dr. Anna Phan:  How social isolation impairs learning
DESCRIPTION:Zoom option if unable to attend in person:\nZoom link here (click on “Join a meeting”)\nMeeting ID: 91512 289258\nPasscode: 289258\n\nSocial isolation and loneliness has been on the rise for the last 20yrs. Many studies have linked increased rates of isolation and loneliness to dementia\, depression\, anxiety\, and other mental health disorders\, but how isolation affects the brain to alter behaviors is unknown. Here\, we focus on how isolation impairs learning and memory in the model organism Drosophila. We’ve found that isolation impairs learning and reduces synaptic proteins in the brains of fruit flies. This appears to cause alterations to their neural circuitry  that impairs learning by reducing the capacity for synaptic plasticity.
URL:https://www.centreforbrainhealth.ca/events/dr-anna-phan/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20241122T110000
DTEND;TZID=America/Vancouver:20241122T120000
DTSTAMP:20260418T145741
CREATED:20240722T202155Z
LAST-MODIFIED:20241021T191637Z
UID:14118-1732273200-1732276800@www.centreforbrainhealth.ca
SUMMARY:Dr. Sepideh Sadaghiani: The connectome multiplex
DESCRIPTION:Zoom option if unable to attend in person:\nZoom link here (click on “Join a meeting”)\nMeeting ID: 91512 289258\nPasscode: 289258\n\nThe human functional connectome has become synonymous with its fMRI heritage\, which yields connectivity on the basis of extremely slow fluctuations of the hemodynamic signal. Recently however\, these slow connectivity patterns have been complemented with fast connectivity from electrophysiological measures. In this talk\, I will discuss synergistic investigations of the functional connectome that use multiple complimentary acquisition methods. This multi-modal approach has demonstrated that the connectome comprises both fast\, oscillation-based connectivity observable in EEG\, and extremely slow connectivity best captured with fMRI. While the fast and slow processes share spatial organization\, these processes unfold in a temporally independent manner. Our findings suggest that equivalent dynamics are engaged across all timescales\, but at different speeds. Infraslow and rapid connectivity of various frequency bands can thus be conceptualized as a multiplex of concurrent trajectories through a shared space of discrete connectome states. In conclusion\, basic and translational research will benefit from comprehensively considering the full breadth of the functional connectome’s timescales.
URL:https://www.centreforbrainhealth.ca/events/dr-sepideh-sadaghiani/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
END:VEVENT
END:VCALENDAR