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X-WR-CALDESC:Events for Djavad Mowafaghian Centre for Brain Health | DMCBH
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DTSTART;TZID=America/Vancouver:20260911T110000
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SUMMARY:Dr. John Lukens: Role of Innate Immune Dysfunction in Neurodegenerative Disease
DESCRIPTION:This talk will introduce emerging roles for microglia and discrete innate immune signaling pathways in the pathogenesis of Alzheimer’s disease\, tauopathies\, and brain injury. \n 
URL:https://www.centreforbrainhealth.ca/events/dr-john-lukens/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
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DTSTART;TZID=America/Vancouver:20260918T110000
DTEND;TZID=America/Vancouver:20260918T120000
DTSTAMP:20260804T193212Z
CREATED:20260206T183003Z
LAST-MODIFIED:20260804T193212Z
UID:17381-1789729200-1789732800@www.centreforbrainhealth.ca
SUMMARY:Dr. Jonathan Pillow: Disentangling the Roles of Distinct Cell Classes with Cell-Type Dynamical Systems
DESCRIPTION:A large body of recent work has focused on the problem of inferring neural population dynamics from recordings of neural activity. However\, these models typically ignore the fact that the brain contains multiple cell types\, which limits their ability to predict the effects of cell-specific perturbations\, or to capture the functional roles of distinct cell classes. To overcome these limitations\, we introduce the “cell-type dynamical systems” (CTDS) model\, which extends latent linear dynamical systems to contain distinct latent variables for each cell class. In this talk\, I will describe the CTDS model and show that it can account for the effects of optogenetic perturbations on behavior — even when fit to unperturbed recordings of neural activity.  Specifically\, I will discuss a multi-region CTDS model fit to simultaneous recordings from rat frontal orienting fields (FOF) and anterior dorsal striatum (ADS) during an auditory decision-making task. Although fit only to unperturbed neural activity\, the model predicts the time-dependent effects of different optogenetic perturbations on behavior\, specifically in FOF\, ADS\, and FOF-to-ADS axon terminals. I will close by discussing future directions and other applications for biologically-constrained dynamical models of neural activity and behavior.
URL:https://www.centreforbrainhealth.ca/events/dr-jonathan-pillow/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
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DTSTART;TZID=America/Vancouver:20260925T110000
DTEND;TZID=America/Vancouver:20260925T120000
DTSTAMP:20260723T183555Z
CREATED:20260326T202019Z
LAST-MODIFIED:20260723T183555Z
UID:17651-1790334000-1790337600@www.centreforbrainhealth.ca
SUMMARY:Dr. Jessica Bolton: Programming vulnerability: The role of microglia in sculpting stress circuits after early-life adversity
DESCRIPTION:Dr. Bolton will discuss how early-life adversity impacts brain development in the context of psychiatric disorders\, with a focus on the role of microglia in the synaptic rewiring of stress-sensitive neurons after early-life adversity. I will also describe our work on sex-dependent differences in microglia and synaptic development\, as well as the molecular mechanisms by which early-life adversity alters microglia.
URL:https://www.centreforbrainhealth.ca/events/dr-jessica-bolton/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
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