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X-WR-CALDESC:Events for Djavad Mowafaghian Centre for Brain Health | DMCBH
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DTSTART;TZID=America/Vancouver:20260410T110000
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SUMMARY:Dr. Mark Brandon:  Stability and drift in neural representations
DESCRIPTION:How does the brain maintain stable internal representations of the world while also remaining flexible enough to learn\, adapt\, and predict the future?  This is a central question in systems neuroscience.  In this talk\, I will present recent work from my lab that addresses this problem at both the level of network dynamics and the level of single-neuron coding. \nFirst I will focus on the head direction system and the concept of network gain as a control parameter that regulates how strongly external landmarks can realign an internal directional attractor during reorientation.  I will describe new data and models that begin to reveal the circuit mechanisms that may tune this gain signal in different behavioral contexts. \nI will then turn to hippocampal representations across days. Using chronic recordings\, we find that not all place cells drift.  In one set of experiments\, a majority of cells whose firing is constrained by environmental geometry can remain remarkably stable across sessions\, whereas other cells show substantial drift.  In a separate set of experiments\, we identify a distinct population of reward coding neurons whose drift is not random but highly organized\, showing a systematic backward shift over learning as an activity transitions from encoding current outcomes to predicting future reward locations. Together\, these studies begin to specify when neural representations are stable\, when they change\, and how that change can follow precise trajectories rather than random wander\, providing concrete constraints for models of long-term spatial memory and its disruption in disease.
URL:https://www.centreforbrainhealth.ca/events/dr-mark-brandon/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
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DTSTART;TZID=America/Vancouver:20260417T110000
DTEND;TZID=America/Vancouver:20260417T120000
DTSTAMP:20260508T003435
CREATED:20250417T190805Z
LAST-MODIFIED:20260113T181536Z
UID:15857-1776423600-1776427200@www.centreforbrainhealth.ca
SUMMARY:Dr. Kelly Dunn: How Can Differences in Opioid Withdrawal Inform New Treatment Strategies?
DESCRIPTION:This presentation will review the need for a precision medicine approach to opioid withdrawal and illustrate how variability in withdrawal symptom expression would inform novel treatment strategies. Differences in withdrawal presentation as a result of illicit fentanyl exposure will be reviewed and results from a randomized trial comparison of a new medication for withdrawal management will be presented
URL:https://www.centreforbrainhealth.ca/events/dr-kelly-dunn/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
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BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20260424T110000
DTEND;TZID=America/Vancouver:20260424T120000
DTSTAMP:20260508T003435
CREATED:20260323T164917Z
LAST-MODIFIED:20260324T172554Z
UID:17592-1777028400-1777032000@www.centreforbrainhealth.ca
SUMMARY:Dr. Mypinder Sekhon: Characterizing The Human Dying Process for translational insights into in vivo Brain Ischemia
DESCRIPTION:The talk will undertake an overview of the physiology of the human dying process as an in vivo model of brain ischemia physiology. The talk will cover the feasibility of undertaking this work at VGH and the characterization of the physiology of circulatory arrest in humans. Additionally\, I will describe preliminary insights into the changes of the proteome and metabolome of the human brain during brain ischemia and use of whole brain autopsies for insights into disease mechanisms.
URL:https://www.centreforbrainhealth.ca/events/dr-mypinder-sekhon/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
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