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X-WR-CALDESC:Events for Djavad Mowafaghian Centre for Brain Health | DMCBH
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DTSTART;TZID=America/Vancouver:20260306T110000
DTEND;TZID=America/Vancouver:20260306T120000
DTSTAMP:20260502T190149
CREATED:20250417T183425Z
LAST-MODIFIED:20260122T232417Z
UID:15851-1772794800-1772798400@www.centreforbrainhealth.ca
SUMMARY:Dr. Cris Niell: Neural circuits for natural vision
DESCRIPTION:Natural visual processing entails a complex interplay between sensory input\, behavioral context\, and on-going brain dynamics. Our lab seeks to understand how these processes give rise to goal-directed visual behaviors\, by exploring the neural circuits mediating ethologically relevant behaviors that laboratory mice perform\, including prey capture and distance estimation. We are also implementing novel experimental approaches to investigate neural coding of the visual scene as animals freely move through their environment. Finally\, I will present a new research direction studying the completely different\, yet largely unexplored\, visual system of the octopus.
URL:https://www.centreforbrainhealth.ca/events/dr-chris-niell/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
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BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20260313T110000
DTEND;TZID=America/Vancouver:20260313T120000
DTSTAMP:20260502T190149
CREATED:20250417T184754Z
LAST-MODIFIED:20251217T173617Z
UID:15853-1773399600-1773403200@www.centreforbrainhealth.ca
SUMMARY:Dr. Keri Martinowich: Spatially-resolved molecular approaches for understanding human brain circuits and disease vulnerability
DESCRIPTION:This talk will highlight recent efforts to generate and analyze spatially resolved molecular datasets to better understand structure–function relationships in the human brain\, particularly in the context of complex brain disorders. While single-cell and single-nucleus sequencing approaches have rapidly advanced our ability to define molecularly distinct cell populations\, these methods often lack the spatial and circuit context necessary to interpret how cells interact within intact brain tissue. I will describe integrative strategies that combine spatial transcriptomics\, single-cell genomics\, and data-driven computational approaches to define molecularly distinct spatial domains within human brain regions\, map cell–cell and circuit-level interactions across these domains\, and identify enrichment of disease-associated molecular profiles in specific cellular and spatial contexts. Across examples from cortical and subcortical circuits\, these approaches provide a framework for understanding how molecular heterogeneity is organized in space and how this organization may confer selective vulnerability in neuropsychiatric and neurodegenerative disease.
URL:https://www.centreforbrainhealth.ca/events/dr-keri-martinowich/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
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BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20260320T110000
DTEND;TZID=America/Vancouver:20260320T120000
DTSTAMP:20260502T190149
CREATED:20250801T201011Z
LAST-MODIFIED:20260318T232607Z
UID:16498-1774004400-1774008000@www.centreforbrainhealth.ca
SUMMARY:Dr. Stephan Lammel: Neural Dynamics of Dopamine Neurons in Motivated Behavior
DESCRIPTION:Despite decades of research on the properties of ventral tegmental area (VTA) dopamine neurons\, the precise information encoded by these cells in reward learning and motivated behavior remains uncertain. In this talk\, I will describe recent work investigating two distinct modalities of the midbrain dopamine system at different levels of investigation. First\, I will present work leveraging an approach that combines Neuropixels recordings and optogenetics to examine dopamine neurons at the single-cell level. In conjunction with computational modeling\, we explored the neural dynamics of dopamine subpopulations across different VTA subregions in mice performing a reward-seeking task. Second\, I will discuss a neural mechanism that explains why a chronic high-fat diet paradoxically diminishes the desire for high-fat\, sugary foods\, even when these foods are easily accessible. We found that this reduction in desire is attributed to decreased neurotensin signaling from nucleus accumbens inputs to dopamine neurons in the lateral VTA. We propose that restoring this desire\, either through dietary modifications or by enhancing neurotensin expression and release\, can drive changes in eating behavior and promote weight loss. Together\, our experiments are geared towards developing comprehensive frameworks for understanding dopamine’s diverse roles in behavior.
URL:https://www.centreforbrainhealth.ca/events/dr-stephan-lammel/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
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DTSTART;TZID=America/Vancouver:20260327T110000
DTEND;TZID=America/Vancouver:20260327T120000
DTSTAMP:20260502T190149
CREATED:20260310T170903Z
LAST-MODIFIED:20260310T170912Z
UID:17542-1774609200-1774612800@www.centreforbrainhealth.ca
SUMMARY:Dr. Zachary Pennington: An amygdala-hypothalamic circuit gates stress vulnerability.
DESCRIPTION:There is substantial individual variability in how individuals respond to stress\, and a major predictor of this variance is the prior experience of stress. Here\, I’ll share data showing that prior stress inflates negative valence signals in an amygdala-hypothalamic circuit and increases stress vulnerability.
URL:https://www.centreforbrainhealth.ca/events/dr-zachary-pennington/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
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