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X-WR-CALDESC:Events for Djavad Mowafaghian Centre for Brain Health | DMCBH
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SUMMARY:Dr. Jean-Claude Béique: A tale of serotonin’s value: from release dynamics to behavioral regulation
DESCRIPTION:Our lab seeks to gain granular descriptions of synaptic\, neuronal and network dynamics in the brain. To this end\, we use a combination of in vitro and in vivo electrophysiology\, two-photon imaging/uncaging\, optogenetics and behavioral approaches\, and use computational simulations to coalesce these levels of analysis in tractable interpretations. I will present results from ongoing work aimed at identifying unifying roles for the neuromodulator serotonin. I will show data supporting the idea that serotonin neurons located in the raphe encodes an estimate of cumulative future rewards\, a quantity referred to as value in reinforcement learning. We further identified unsuspected network organization and serotonin release dynamics in the raphe that\, collectively\, impart highly non-linearly processing features of long-range synaptic inputs and behavioral regulation. Collectively\, this work is beginning to identify elemental computations that may be involved in animal’s ability to optimally adapt their behavioral policies to changing environmental contexts.
URL:https://www.centreforbrainhealth.ca/events/dr-jean-claude-beique/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
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