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X-WR-CALDESC:Events for Djavad Mowafaghian Centre for Brain Health | DMCBH
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UID:15841-1759489200-1759492800@www.centreforbrainhealth.ca
SUMMARY:Dr. Erik Bloss: Synapse plasticity in learning and disease states
DESCRIPTION:Synapses are the computational subunits of the brain. They allow cell-type specific forms of information flow\, permit neurons to compartmentalize electrical and biochemical signals\, and undergo rapid structural plasticity during experience. Although Crick suggested spine plasticity was a correlate of memory more than 40 years ago\, it has been hard to understand precisely how the plasticity of spines drives cognitive function. We have examined this issue in two contexts: one in which mice are required to learn competing memory traces\, and one in which mice are engineered to express mutant amyloid as a model of Alzheimer’s disease (AD). I will present unpublished data that suggest adaptive learning requires spine plasticity in specific cortical neurons\, at specific synaptic sites\, and in a sex-specific manner. In AD mice\, the loss of synapses appears to coincide with interference between memory traces. These results suggest new ways in which plasticity might support memory functions.
URL:https://www.centreforbrainhealth.ca/events/dr-erik-bloss/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
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DTSTART;TZID=America/Vancouver:20251024T110000
DTEND;TZID=America/Vancouver:20251024T120000
DTSTAMP:20260503T034839
CREATED:20250417T181954Z
LAST-MODIFIED:20250815T203832Z
UID:15845-1761303600-1761307200@www.centreforbrainhealth.ca
SUMMARY:Dr. Nicolas Tritsch: Dopamine and Movement: Defining Timescales of Modulation
DESCRIPTION:Ever since the discovery that the degeneration of midbrain DA neurons (mDANs) projecting to the striatum underlies bradykinesia (i.e.\, slowness of movement) in Parkinson’s disease (PD)\, DA has become synonymous with motor vigor. However\, the mechanisms through which DA contributes to the speed and amplitude of individual voluntary movements are still debated. Initial investigations suggested a somewhat slow or permissive role for DA\, but recent experiments in rodents proposed a stronger and faster role for DA in the dynamic control of the gain of motor commands. In this presentation\, I will describe our attempts at better understanding how dopamine contributes to motor vigor through the study of release patterns\, lesions\, and optogenetic and pharmacological manipulations. Our findings call into question the widely-held view that phasic fluctuations in extracellular dopamine control the vigor of ongoing movements\, constraining the kinds of mechanisms and timescales that dopamine likely acts on to modify behavior. \n 
URL:https://www.centreforbrainhealth.ca/events/dr-nicolas-tritsch/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
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BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20251031T110000
DTEND;TZID=America/Vancouver:20251031T120000
DTSTAMP:20260503T034839
CREATED:20250423T203759Z
LAST-MODIFIED:20251003T162242Z
UID:15873-1761908400-1761912000@www.centreforbrainhealth.ca
SUMMARY:Dr. Michael Yellow Bird: The Power of Ceremony: Indigenous Contemplative Practices\, Neurodecolonization\, and the Medicine Wheel
DESCRIPTION:Indigenous contemplative practices and teachings have enabled Indigenous Peoples to develop an important paradigm of healing that has important implications for western medicine and health care providers who work with Indigenous Peoples. In this presentation\, Dr. Michael Yellow Bird uses Indigenous wisdom and western science to show how Indigenous contemplative approaches can create important changes in the brain and body and can prevent\, heal\, and cure\, many emotional and physical diseases brought about by colonization and the current Western industrial lifestyle.
URL:https://www.centreforbrainhealth.ca/events/dr-michael-yellow-bird/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
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