BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Djavad Mowafaghian Centre for Brain Health | DMCBH - ECPv6.15.18//NONSGML v1.0//EN
CALSCALE:GREGORIAN
METHOD:PUBLISH
X-WR-CALNAME:Djavad Mowafaghian Centre for Brain Health | DMCBH
X-ORIGINAL-URL:https://www.centreforbrainhealth.ca
X-WR-CALDESC:Events for Djavad Mowafaghian Centre for Brain Health | DMCBH
REFRESH-INTERVAL;VALUE=DURATION:PT1H
X-Robots-Tag:noindex
X-PUBLISHED-TTL:PT1H
BEGIN:VTIMEZONE
TZID:America/Vancouver
BEGIN:DAYLIGHT
TZOFFSETFROM:-0800
TZOFFSETTO:-0700
TZNAME:PDT
DTSTART:20230312T100000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:-0700
TZOFFSETTO:-0800
TZNAME:PST
DTSTART:20231105T090000
END:STANDARD
BEGIN:DAYLIGHT
TZOFFSETFROM:-0800
TZOFFSETTO:-0700
TZNAME:PDT
DTSTART:20240310T100000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:-0700
TZOFFSETTO:-0800
TZNAME:PST
DTSTART:20241103T090000
END:STANDARD
BEGIN:DAYLIGHT
TZOFFSETFROM:-0800
TZOFFSETTO:-0700
TZNAME:PDT
DTSTART:20250309T100000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:-0700
TZOFFSETTO:-0800
TZNAME:PST
DTSTART:20251102T090000
END:STANDARD
END:VTIMEZONE
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20241101T110000
DTEND;TZID=America/Vancouver:20241101T120000
DTSTAMP:20260421T143940
CREATED:20240320T233835Z
LAST-MODIFIED:20240806T181502Z
UID:13085-1730458800-1730462400@www.centreforbrainhealth.ca
SUMMARY:Dr. Edmund Au: Elucidating Principles of Cortical Interneuron Synaptic Organization
DESCRIPTION:Zoom option if unable to attend in person:\nZoom link here (click on “Join a meeting”)\nMeeting ID: 91512 289258\nPasscode: 289258\n\nCortical interneurons are the most transcriptionally and morphologically diverse neurons in the brain\, characterized in part by their striking degree of synaptic specificity. However\, little is known about the extent of their synaptic diversity due to the lack of unbiased methods to extract features of synaptic organization among interneuron subtypes. In this talk\, I will introduce an approach we developed that combines imaging and computational extraction of synaptic features from genetically-identified interneuron synapses and their subcellular specificity among postsynaptic targets. A machine-learning approach (1) reveals hundreds of spatial and structural features from each analyzed synapse\, (2) constructs a multidimensional data set\, consisting of millions of synapses\, and (3) uncovers novel synaptic subgroups. By analyzing this dataset\, we found that dendrite-targeting synaptic subgroups were clustered onto distinct subdomains of the dendrite along the proximal to distal axis; Soma-targeting subgroups were enriched onto different postsynaptic cell types; Finally\, the two main subclasses of interneurons\, basket cells and somatostatin interneurons\, utilize distinct strategies to enact inhibitory synaptic coverage. Thus\, we uncover previously unknown structural and topological features of inhibitory synaptic organization and establishes a conceptual framework for studying inhibitory synaptic diversity in health and disease.
URL:https://www.centreforbrainhealth.ca/events/dr-edmund-au/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20241115T110000
DTEND;TZID=America/Vancouver:20241115T120000
DTSTAMP:20260421T143940
CREATED:20240321T193757Z
LAST-MODIFIED:20240808T173346Z
UID:13094-1731668400-1731672000@www.centreforbrainhealth.ca
SUMMARY:Dr. Anna Phan:  How social isolation impairs learning
DESCRIPTION:Zoom option if unable to attend in person:\nZoom link here (click on “Join a meeting”)\nMeeting ID: 91512 289258\nPasscode: 289258\n\nSocial isolation and loneliness has been on the rise for the last 20yrs. Many studies have linked increased rates of isolation and loneliness to dementia\, depression\, anxiety\, and other mental health disorders\, but how isolation affects the brain to alter behaviors is unknown. Here\, we focus on how isolation impairs learning and memory in the model organism Drosophila. We’ve found that isolation impairs learning and reduces synaptic proteins in the brains of fruit flies. This appears to cause alterations to their neural circuitry  that impairs learning by reducing the capacity for synaptic plasticity.
URL:https://www.centreforbrainhealth.ca/events/dr-anna-phan/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20241122T110000
DTEND;TZID=America/Vancouver:20241122T120000
DTSTAMP:20260421T143940
CREATED:20240722T202155Z
LAST-MODIFIED:20241021T191637Z
UID:14118-1732273200-1732276800@www.centreforbrainhealth.ca
SUMMARY:Dr. Sepideh Sadaghiani: The connectome multiplex
DESCRIPTION:Zoom option if unable to attend in person:\nZoom link here (click on “Join a meeting”)\nMeeting ID: 91512 289258\nPasscode: 289258\n\nThe human functional connectome has become synonymous with its fMRI heritage\, which yields connectivity on the basis of extremely slow fluctuations of the hemodynamic signal. Recently however\, these slow connectivity patterns have been complemented with fast connectivity from electrophysiological measures. In this talk\, I will discuss synergistic investigations of the functional connectome that use multiple complimentary acquisition methods. This multi-modal approach has demonstrated that the connectome comprises both fast\, oscillation-based connectivity observable in EEG\, and extremely slow connectivity best captured with fMRI. While the fast and slow processes share spatial organization\, these processes unfold in a temporally independent manner. Our findings suggest that equivalent dynamics are engaged across all timescales\, but at different speeds. Infraslow and rapid connectivity of various frequency bands can thus be conceptualized as a multiplex of concurrent trajectories through a shared space of discrete connectome states. In conclusion\, basic and translational research will benefit from comprehensively considering the full breadth of the functional connectome’s timescales.
URL:https://www.centreforbrainhealth.ca/events/dr-sepideh-sadaghiani/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20241129T110000
DTEND;TZID=America/Vancouver:20241129T120000
DTSTAMP:20260421T143940
CREATED:20240321T201659Z
LAST-MODIFIED:20240809T165648Z
UID:13099-1732878000-1732881600@www.centreforbrainhealth.ca
SUMMARY:Dr. Paul Frankland: Ontogeny of hippocampus-dependent memory
DESCRIPTION:Zoom option if unable to attend in person:\nZoom link here (click on “Join a meeting”)\nMeeting ID: 91512 289258\nPasscode: 289258\n\nMemories for events (i.e.\, episodic memories) formed in early development differ from those in adulthood in at least two regards. First\, these memories tend to be rapidly forgotten (i.e.\, infantile amnesia). Second\, they tend to be less precise than those formed in adulthood (i.e.\, infantile generalization). My talk will focus on the neurobiological mechanisms that account for these different operating characteristics of episodic memory in the developing brain. With respect to infantile amnesia\, we have shown that maturation of cortical circuits is necessary for the formation of enduring event memories. With respect to infantile generalization\, our studies reveal that maturation of inhibitory microcircuits in the hippocampus are necessary for the formation of adult-like\, precise memories for events.
URL:https://www.centreforbrainhealth.ca/events/dr-paul-frankland/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
END:VEVENT
END:VCALENDAR