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X-WR-CALNAME:Djavad Mowafaghian Centre for Brain Health | DMCBH
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X-WR-CALDESC:Events for Djavad Mowafaghian Centre for Brain Health | DMCBH
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DTSTART;TZID=America/Vancouver:20230908T110000
DTEND;TZID=America/Vancouver:20230908T120000
DTSTAMP:20260418T182059
CREATED:20220713T185639Z
LAST-MODIFIED:20230822T172316Z
UID:9307-1694170800-1694174400@www.centreforbrainhealth.ca
SUMMARY:Dr. Linda Overstreet-Wadiche: Adult-born neurons in the hippocampal network
DESCRIPTION:Zoom option if unable to attend in person:\nZoom link here (click on “Join a meeting”)\nMeeting ID: 91512 289258\nPasscode: 289258\n\nThe adult dentate gyrus continually produces new neurons that integrate into the hippocampal circuit. Adult-born neurons transiently exhibit distinct cellular properties that distinguish them from the larger population of mature neurons\, and these properties are thought to underlie the vital role of neurogenesis in hippocampal behaviors. I will review the developmental trajectory of adult-born neuron cellular properties and present new data focused on cellular mechanisms of “critical periods” for plasticity and information processing. The results support the idea that neurogenesis provides a substrate for experience-dependent circuit plasticity and memory precision.
URL:https://www.centreforbrainhealth.ca/events/dr-linda-overstreet-wadiche-2/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
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BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20230915T110000
DTEND;TZID=America/Vancouver:20230915T120000
DTSTAMP:20260418T182059
CREATED:20220706T204712Z
LAST-MODIFIED:20230901T170859Z
UID:9251-1694775600-1694779200@www.centreforbrainhealth.ca
SUMMARY:Dr. Maya Koronyo: Retinal manifestations of Alzheimer’s disease
DESCRIPTION:Zoom option if unable to attend in person:\nZoom link here (click on “Join a meeting”)\nMeeting ID: 91512 289258\nPasscode: 289258\n\nThe neural retina is a key organ for vision and visual processing. As a direct extension of the brain\, it emerges as a prominent site impacted by Alzheimer’s disease (AD).  The retina is the only CNS tissue not shielded by bone that can be easily accessible for noninvasive\, affordable\, ultra-high-resolution imaging in the clinical setting. Data from recent years strongly suggest it can serve as a window to assess AD. Early studies described retinal nerve fiber layer and ganglion cell degeneration. Our team revealed the accumulation of core AD hallmarks—amyloid β-protein (Aβ) plaques and neurofibrillary tangles—in the retina of AD and mild cognitive impairment (MCI) patients. Subsequent studies confirmed these findings\, and further reported visual and electroretinography abnormalities\, retinal tauopathy\, Aβ oligomers\, inflammation\, and cell-specific degeneration in AD patients. Data from our group and others suggest that the brain and retina follow a similar trajectory during AD progression\, potentially due to their shared embryonic origin and anatomical proximity. Moreover\, retinal vascular irregularities—vessel density and fractal dimensions\, blood flow\, foveal avascular zone\, curvature tortuosity\, arteriole-to-venule ratio—are present in AD patients\, including early-stage cases. A tight association between cerebral and retinal vasculopathy to cognitive deficits was reported in AD patients and animal models. More recently\, we identified early and progressive retinal vascular platelet-derived growth factor receptor-β (PDGFRβ) deficiency and pericyte loss\, as well as retinal endothelial tight junction losses in MCI and AD patients. These retinal vasculopathies strongly link to vascular amyloid accumulation as well as could predict the severity of cerebral amyloid angiopathy. Currently\, we explore the complex landscape of Alzheimer’s in the retina\, including AD-related molecular signatures and processes\, new forms of proteinopathies\, vascular and inflammatory abnormalities\, synaptic loss\, as well as cell-specific vulnerability and resilience. Establishing how early retinal biomarkers can be detected during AD continuum and what do they mean for brain pathology and functional decline\, should guide the development of future retinal imaging technologies to improve early\, noninvasive AD diagnosis and monitoring. \n 
URL:https://www.centreforbrainhealth.ca/events/dr-maya-koronyo/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
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BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20230922T110000
DTEND;TZID=America/Vancouver:20230922T120000
DTSTAMP:20260418T182059
CREATED:20230725T202300Z
LAST-MODIFIED:20230822T172441Z
UID:11438-1695380400-1695384000@www.centreforbrainhealth.ca
SUMMARY:Dr. Jibran Khokhar: Cannabis and the Vulnerable Brain: A Closer Look at Genetics\, Adolescence\, and Edible Overdose
DESCRIPTION:Zoom option if unable to attend in person:\nZoom link here (click on “Join a meeting”)\nMeeting ID: 91512 289258\nPasscode: 289258\n\nDr. Khokhar will talk about the behavioural and neural correlates of various types of vulnerabilities to cannabis\, starting from genetic risk for cannabis use\, to vaping in adolescence\, to the recent increases in edible overdoses in children and pets.
URL:https://www.centreforbrainhealth.ca/events/dr-jibran-khokhar/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20230929T110000
DTEND;TZID=America/Vancouver:20230929T120000
DTSTAMP:20260418T182059
CREATED:20220604T014843Z
LAST-MODIFIED:20230822T172524Z
UID:9076-1695985200-1695988800@www.centreforbrainhealth.ca
SUMMARY:Dr. Richard Mooney: From song to synapse
DESCRIPTION:Zoom option if unable to attend in person:\nZoom link here (click on “Join a meeting”)\nMeeting ID: 91512 289258\nPasscode: 289258\n\nVocalizations are an essential medium for social and sexual signaling in mammals and birds.  Whereas most animals only produce innate vocalizations\, songbirds learn to sing in a process with many parallels to human speech learning. I will discuss recent advances from our lab highlighting the neural mechanisms that enable birdsong learning\, including basal ganglia-dependent vocal exploration and reinforcement. How the learned song is integrated with innate vocalizations will also be considered\, with reference to recent studies that genetically map neural circuits for innate vocalizations in mice. \n 
URL:https://www.centreforbrainhealth.ca/events/dr-richard-mooney/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
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