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X-WR-CALNAME:Djavad Mowafaghian Centre for Brain Health | DMCBH
X-ORIGINAL-URL:https://www.centreforbrainhealth.ca
X-WR-CALDESC:Events for Djavad Mowafaghian Centre for Brain Health | DMCBH
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DTSTART;TZID=America/Vancouver:20230303T110000
DTEND;TZID=America/Vancouver:20230303T120000
DTSTAMP:20260418T095257
CREATED:20220714T200002Z
LAST-MODIFIED:20230302T010113Z
UID:9315-1677841200-1677844800@www.centreforbrainhealth.ca
SUMMARY:UBC Kickstart Updates: Drs. Annie Ciernia and Paul van Donkelaar
DESCRIPTION:Dr. Annie Ciernia: “Mechanisms of Peripheral Lipopolysaccharide Induced Brain Inflammation”\nDr. Paul van Donkelaar: “Characterizing tau pathology in survivors of intimate partner violence-related traumatic brain injury”\nZoom option if unable to attend in person:\nZoom link here (click on “Join a meeting”)\nMeeting ID: 91512 289258\nPasscode: 289258
URL:https://www.centreforbrainhealth.ca/events/ubc-kickstart-updates-drs-annie-ciernia-and-paul-van-donkelaar/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
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BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20230310T110000
DTEND;TZID=America/Vancouver:20230310T120000
DTSTAMP:20260418T095257
CREATED:20220714T200422Z
LAST-MODIFIED:20230308T233026Z
UID:9317-1678446000-1678449600@www.centreforbrainhealth.ca
SUMMARY:UBC Kickstart Updates: Neha Suvindran and Drs. Rebecca Todd & Stan Floresco
DESCRIPTION:Neha Suvindran: “Reimagining Neuro-Bioelectronic Systems: Sustainable\, Stable and Self-healing Fiber Electrodes”\nDrs. Rebecca Todd and Stan Floresco: “Translation Investigation of Neurophysiological Substrates of Active and inhibitory Avoidance in healthy and depressed populations.”\nZoom option if unable to attend in person:\nZoom link here (click on “Join a meeting”)\nMeeting ID: 91512 289258\nPasscode: 289258
URL:https://www.centreforbrainhealth.ca/events/ubc-kickstart-updates-neha-suvindran-and-rebecca-todd/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20230317T110000
DTEND;TZID=America/Vancouver:20230317T120000
DTSTAMP:20260418T095257
CREATED:20210722T000000Z
LAST-MODIFIED:20230109T182025Z
UID:3748-1679050800-1679054400@www.centreforbrainhealth.ca
SUMMARY:Dr. Michael Drew: Hippocampal mechanisms of fear suppression and relapse
DESCRIPTION:Zoom option if unable to attend in person:\nZoom link here (click on “Join a meeting”)\nMeeting ID: 91512 289258\nPasscode: 289258\n\nLearned fear often relapses after extinction\, suggesting that extinction training generates a new memory that coexists with the original fear memory. Recent work from our lab has identified the hippocampus as a region where such fear and extinction memories exist and compete for expression. In this talk I will discuss recent work in our lab in which we have used activity-dependent neural tagging in mice to identify\, manipulate\, and characterize the cellular mechanisms of these hippocampal fear and extinction memories. I will discuss (1) where in the hippocampus these memory representations exist\, (2) evidence that fear and extinction memories are coded by molecularly distinct cell ensembles\, and (3) evidence that expression of fear and extinction is mediated by activation unique hippocampal output pathways.
URL:https://www.centreforbrainhealth.ca/events/dr-michael-drew/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
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BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20230324T110000
DTEND;TZID=America/Vancouver:20230324T120000
DTSTAMP:20260418T095257
CREATED:20221201T201738Z
LAST-MODIFIED:20230117T213557Z
UID:10052-1679655600-1679659200@www.centreforbrainhealth.ca
SUMMARY:Dr. Kathleen Morrison: Role for chromatin remodeling in the lifelong consequences of pubertal adversity on the brain and behavior
DESCRIPTION:Zoom option if unable to attend in person:\nZoom link here (click on “Join a meeting”)\nMeeting ID: 91512 289258\nPasscode: 289258\n\nPuberty and ensuing adolescence represent a time when the brain is rapidly developing and is sensitive to environmental stimuli. This lecture will discuss evidence that pubertal adversity puts females at risk for altered stress responding and maternal behavior later in life. Evidence will be presented that pubertal stress leads to an enduring programmatic event in the chromatin landscape in several brain regions\, which may underlie both the lasting transcriptomic and behavioral consequences of pubertal stress.
URL:https://www.centreforbrainhealth.ca/events/dr-kathleen-morrison/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20230331T110000
DTEND;TZID=America/Vancouver:20230331T120000
DTSTAMP:20260418T095257
CREATED:20210722T000000Z
LAST-MODIFIED:20230320T224544Z
UID:3747-1680260400-1680264000@www.centreforbrainhealth.ca
SUMMARY:Dr. Joseph Cheer: Endogenous cannabinoids and the pursuit of reward
DESCRIPTION:Zoom option if unable to attend in person:\nZoom link here (click on “Join a meeting”)\nMeeting ID: 91512 289258\nPasscode: 289258\n\nIn the early stages of substance abuse\, subjects receive a drug that is highly reinforcing and are thus likely to repeat the actions that led them to obtain it.  This is termed positive reinforcement. However\, in a minority of people who develop an addiction phenotype\, negative reinforcement also causes a behavior to be repeated\, but in this case\, the action causes a bad feeling or situation to go away. The mesolimbic dopamine system\, which is thought to generate a teaching signal\, is involved in the selection of advantageous behavioral repertoires. This brain pathway is under control of endocannabinoid (eCBs)\, ubiquitous signaling molecules that bind to the same receptor targeted by marijuana (CB1) known to strengthen responses leading to the procurement of reward. Here\, we investigate how eCBs modulate dopaminergic encoding of cues predicting either\, appetitive stimuli\, the avoidance of punishment or aversive outcomes. We find that disrupting eCB signaling by treating animals with a CB1 receptor antagonist dose-dependently decreased concentrations of dopamine release in the nucleus accumbens that were time-locked to a warning signal that predicts avoidance of punishment while simultaneously weakening shock avoidance behavior\, effectively shifting the behavioral outcome from avoidance to escape. We further demonstrate\, using directed mutagenesis approaches\, that 2AG release from dopamine neurons in the midbrain is a canonical mechanism responsible for the pursuit of rewards. \nIt has been posited that compromised motivation in HD or “apathy” arises from a deficit in preparing for and initiating goal-directed behavior. Apathy is always the primary deficit in motivation associated with frontal-subcortical diseases such as HD. Indeed\, apathy may be a core feature of HD disease pathology itself. In many cases apathy follows a similar trajectory as motor symptom progression in PD\, although it can become prevalent before phenoconversion. It can be the result of several neurobiologically maladaptive systems\, including affective (flattening of emotional responsiveness)\, behavioral (reduced initiation of spontaneous behavior)\, and executive dysfunction (difficulty planning/executing). Thus\, motivational dysfunction in HD is a deficit primarily in preparation for motivated behavior that can have debilitating co-morbid consequences. \nGaps in knowledge \n\nLoss of striatal cannabinoid type 1 (CB1) receptors is a key pathogenic of several neurodegenerative diseases\, including HD.\nTreatment for metabolic syndrome with the CB1 receptor antagonist Rimonabant was halted by the FDA because of loss of motivation and depressive ideation.\nHD patients tend to smoke marijuana as a way to self-medicate and to prevent feelings of loneliness and helplessness.\nLoss of goal-directed behavior in HD is specific to the incentive value of the reinforcer.\nTreatment with indirect cannabinoid agonists profoundly increases operationally defined indices of motivation in normal animals and reverses apathy via dopaminergic mechanisms in mouse models of HD.\n\nTogether these data suggest that eCBs might modify distinct behavioral responses related to exteroceptive stimuli by modulating conditioned mesolimbic dopamine release events.  These findings suggest that therapies aimed at modifying tissue levels of eCBs may be used to prevent drug seeking driven by negative affective states or improve motivational indices in animal models of HD. \n 
URL:https://www.centreforbrainhealth.ca/events/dr-joseph-cheer/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
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