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X-WR-CALNAME:Djavad Mowafaghian Centre for Brain Health | DMCBH
X-ORIGINAL-URL:https://www.centreforbrainhealth.ca
X-WR-CALDESC:Events for Djavad Mowafaghian Centre for Brain Health | DMCBH
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DTSTART;TZID=America/Vancouver:20220909T110000
DTEND;TZID=America/Vancouver:20220909T120000
DTSTAMP:20260418T195351
CREATED:20220604T013640Z
LAST-MODIFIED:20220805T201639Z
UID:9060-1662721200-1662724800@www.centreforbrainhealth.ca
SUMMARY:Dr. Anke Henning: Metabolic MRI at ultra-high fields – from systems architecture to application
DESCRIPTION:Metabolic MRI allows observing energy metabolism\, neurotransmission\, second messaging\, endocrine signaling\, antioxidants\, protein metabolism and dynamic membrane processes in the human brain. Related quantitative metabolic imaging biomarkers are beneficial for differential diagnostics\, monitoring of treatment response and patient stratification in various neurological and psychiatric disorders and yield complementary information to structural and functional imaging. To visualize related metabolic processes my research group develops methodology for highly spatially and temporally resolved metabolic imaging exploiting magnetic resonance spectroscopy (MRS)\, chemical exchange saturation transfer (CEST) and non-proton spectroscopic imaging (31P\, 13C\, 2H) at 3T\, 7T and 9.4T with application in the human brain\, spinal cord and myocardium. These methods allows for non-invasive and non-ionizing determination of tissue concentrations and metabolic turn-over rates of more than 20 metabolites and ions and specifically benefits from ultrahigh field strength with regard to spectral resolution and signal-to-noise ratio. \nHowever\, specific physical and technical challenges have to be overcome to fully exploit the advantages of ultrahigh field MR at 7T and 9.4T for human MRI and MRS. Hence my laboratory invests into the development of enabling technology for ultrahigh field MRI including scan hardware such as radiofrequency coils and static magnetic field shimming\, numerical optimization of these setups and is able to perform respective safety assessment to allow for application in humans. The lab also develops scan software including MRI sequences and is able to design tailored radiofrequency pulse including such dedicated to parallel transmission systems. Specifically for metabolic MRI we also develop tailored data analysis methods such as image reconstruction\, post-processing and quantification pipelines and recently started to explore machine-learning based approaches. \nThis presentation gives an overview over our recent research activities. \nZoom option if unable to attend in person \n\nZoom link here (click on “Join a meeting”)\nMeeting ID: 99412 188589\nPasscode: 188589
URL:https://www.centreforbrainhealth.ca/events/dr-anke-henning/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
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DTSTART;TZID=America/Vancouver:20220916T110000
DTEND;TZID=America/Vancouver:20220916T120000
DTSTAMP:20260418T195351
CREATED:20220604T013819Z
LAST-MODIFIED:20220815T171642Z
UID:9062-1663326000-1663329600@www.centreforbrainhealth.ca
SUMMARY:Dr. Kim Green: Exploring  microglia  function  in  the healthy and Alzheimer’s disease brain
DESCRIPTION:Microglia are the primary immune cell of the brain\, but have roles outside of immunity as well as being implicated in the pathogenesis of many CNS disorders. Here I will show how we can use CSF1R inhibitors to control the microglial population in vivo\, and elucidate their functions in both the homeostatic and disease brains. I will focus on the involvement of microglia in Alzheimer’s disease\, and also detail several new genetic models to understand the disease progression. \nZoom option if unable to attend in person \n\nZoom link here (click on “Join a meeting”)\nMeeting ID: 99412 188589\nPasscode: 188589
URL:https://www.centreforbrainhealth.ca/events/dr-kim-green/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
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DTSTART;TZID=America/Vancouver:20220923T110000
DTEND;TZID=America/Vancouver:20220923T120000
DTSTAMP:20260418T195351
CREATED:20220604T014013Z
LAST-MODIFIED:20220808T163820Z
UID:9064-1663930800-1663934400@www.centreforbrainhealth.ca
SUMMARY:Dr. Eugenii A. (Ilan) Rabiner: Molecular Imaging in CNS drug development
DESCRIPTION:Zoom option if unable to attend in person \n\nZoom link here (click on “Join a meeting”)\nMeeting ID: 99412 188589\nPasscode: 188589\n\nOver the past 25 years the costs of drug development have been rising steeply\, with later phases being particularly resource intensive. Molecular imaging (primarily PET) has become an indispensable tool in early phase drug development\, especially for compounds focused on CNS targets\, PET studies conducted at an appropriate enable the refinement of the dose range to be explored in later phase studies\, leading to time and resource savings\, as well as providing early demonstration of compounds that are going to fail\, leading to early termination and the reallocation of considerable resources. This talk will discuss the application of PET and MR imaging in early phase drug development\, within the framework of the “three pillars” of drug development and provide examples of such studies.
URL:https://www.centreforbrainhealth.ca/events/dr-eugenii-a-ilan-rabiner/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
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