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SUMMARY:Dr. Elizabeth Heller: Epigenetic regulation of reward pathophysiology
DESCRIPTION:The Heller Lab research program is focused on discovering molecular mechanisms by which epigenetic reprogramming contributes to neuropsychiatric disease. To this end\, Dr. Heller pioneered the use of targeted epigenetic editing in brain\, to elucidate the precise causal role of histone posttranslational modifications on gene expression and alternative splicing in specific neuronal subpopulations. Dr. Heller will share recent studies of epigenetic regulation of gene expression and alternative splicing across cocaine abstinence in mice\, as well as novel approaches to examine histone modifications in specific neuronal subpopulations. \nZoom option if unable to attend in person \n\nZoom link here (click on “Join a meeting”)\nMeeting ID: 99412 188589\nPasscode: 188589
URL:https://www.centreforbrainhealth.ca/events/dr-elizabeth-heller/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
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SUMMARY:Dr. Takao Hensch: Balancing Brain Plasticity/Stability
DESCRIPTION:Brain function is largely shaped by experience in early life\, creating windows of both great opportunity and vulnerability. Our work has focused on the biological basis for such critical periods\, identifying both “triggers” and “brakes” on plasticity. Strikingly\, the maturation of particular inhibitory circuits is pivotal for the onset timing of these windows. Manipulations of their emergence can either accelerate or delay developmental trajectories regardless of chronological age. Notably\, many neurodevelopmental disorders are linked to alterations in excitatory-inhibitory balance\, suggesting shifted critical period timing as part of their etiology. Closure of critical periods in turn reflects an active process\, rather than a purely passive loss of plasticity factors. Lifting these brakes allows the reopening of plastic windows later in life\, but may also underlie instability in disease states. Thus\, understanding how brain plasticity and stability are balanced throughout life offers new insight into mental illness and novel therapeutic strategies for recovery of function in adulthood. \n\nZoom option if unable to attend in person\nZoom link here (click on “Join a meeting”)\nMeeting ID: 99412 188589\nPasscode: 188589\n\nTo attend the trainee lunch following the seminar or to schedule a meeting with Dr. Hensch\, please email Kim at kschmidt@mail.ubc.ca
URL:https://www.centreforbrainhealth.ca/events/dr-takao-hensch/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
ATTACH;FMTTYPE=image/jpeg:https://www.centreforbrainhealth.ca/wp-content/uploads/2022/04/Takao-Hensch-presentation-May-13.jpg
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