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Molecular Mechanisms of Synaptic Plasticity: A Tale of Two Receptors
12:30pm-1:30pm, Apr 27, 2017
LSC3, Life Sciences Centre, 2350 Health Sciences Mall
Dr. Andrés Barría
Join host Dr. Shernaz Bamji for this special guest talk.
A fundamental aspect of neuronal biology is the establishment of synaptic connections and their experience-dependent modification throughout life. Synaptic plasticity refers to the process that allows neurons to re-adjust their connectivity in a usage-dependent manner. This process is essential for the establishment and maturation of functional neuronal circuits during development and it is thought to be one of the cellular bases for learning and memory.
The NMDA-type glutamate receptor plays a key role in initiating modifications at synapses in response to incoming synaptic activity. I will discuss the role of two different type of NMDARs and their regulation by a recently identified Wnt signaling cascade.