Multiple Sclerosis - CCSVI

Welcome. The information contained within these pages speaks to research and other initiatives being undertaken through the UBC Hospital MS Clinic.

The research is supported by Vancouver Coastal Health Research Institute and UBC Faculty of Medicine. Our hope is to provide you with an outline of the research activities of the UBC Hospital MS Clinic related to CCSVI as well as general Question and Answers and helpful links related to this topic, and to CCSVI research at UBC Hospital.

Interventional venous treatment for CCSVI is not available in Canada and is still considered experimental. Staff, clinicians, and researchers at UBC Hospital MS Clinic do not recommend Canadians travel outside the country to seek treatment at this point as safety implications, effectiveness, and sustainability of the procedure are not fully understood.

MS-CCSVI Diagnostic Study


In 2009, a study by Dr. Zamboni in Italy claimed that all patients with multiple sclerosis (MS) had significant blockages in the neck veins (jugular and azygous). Termed chronic cerebral spinal venous insufficiency (CCSVI), he believed this created back pressure into the brain and was an important cause of MS and MS symptoms. He treated 65 patients with vein dilation (angio or venoplasty) and some reported significant improvement, calling this the “liberation” treatment. The liberation treatment is not routinely performed in Canada.

MS-CCSVI Phase I/II Treatment Trial

The UBC Hospital MS Clinic is leading a new national CCSVI treatment trial called Phase I/II Interventional Clinical Trial of Balloon Venoplasty for CCSVI (Chronic Cerebrospinal Venous Insufficiency) in Multiple Sclerosis patients.

The trial is funded by CIHR, with support from the provinces of British Columbia and Quebec as well as the MS Society of Canada.